The volumes in this authoritative series present a
multidisciplinary approach to modeling and simulation of flows in
the cardiovascular and ventilatory systems, especially multiscale
modeling and coupled simulations. Volume 5 is devoted to cells,
tissues, and organs of the cardiovascular and ventilatory systems
with an emphasis on mechanotransduction-based regulation of flow.
The blood vessel wall is a living tissue that quickly reacts to
loads applied on it by the flowing blood. In any segment of a blood
vessel, the endothelial and smooth muscle cells can sense unusual
time variations in small-magnitude wall shear stress and
large-amplitude wall stretch generated by abnormal hemodynamic
stresses. These cells respond with a short-time scale (from seconds
to hours) to adapt the vessel caliber. Since such adaptive cell
activities can be described using mathematical models, a key
objective of this volume is to identify the mesoscopic agents and
nanoscopic mediators required to derive adequate mathematical
models. The resulting biomathematical models and corresponding
simulation software can be incorporated into platforms developed in
virtual physiology for improved understanding and training.
General
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