This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity.
Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems.
Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems
discusses the crucial relationship between the transport process and thermodynamic factors
analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces
covers prodrug design for improving membrane transport
addresses the effects of external stimuli in altering some natural and synthetic polymer matrices
examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability
presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions
and more
Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.

In industry, miscommunication can cause frustration, create downtime, and even trigger equipment failure. By providing a common ground for more effective discourse, the Dictionary of Oil, Gas, and Petrochemical Processing can help eliminate costly miscommunication. An essential resource for oil, gas, and petrochemical industry professionals, engineers, academic staff, and science and engineering students, the dictionary defines over 5,000 technical and commercial terms encompassing exploration, production, processing, refining, pipelining, finance, management, and safety. From basic engineering principles to the latest drilling technology, the text covers the fundamentals and their real-world applications. Alphabetically arranged for quick reference, it contains easy-to-understand descriptions and figures, as well as oil and gas SI units and metric equivalents. Industry newcomers and personnel with no technical background especially benefit from the book's practical language that clearly demonstrates the concepts behind the definitions.

This revised edition provides the basics of applying hazard and operability study (Hazop) and hazard analysis (Hazan). Hazop is a creative but systematic method of identifying hazards in process plants. Hazard analysis is then used to quantify the risks from these hazards, and to assess how far to go in reducing them. This book is presented in easy-to-read style and explains: what a Hazop is, who carries it out, when, and how long it should take; points to watch during a Hazop; an example of a Hazop; Hazops on flowsheets; the stages of Hazard analysis; the Fatal Accident Rate; risks to the public; estimating how often an accident will occur, with examples; and pitfalls in Hazan.

With their broad range of properties, polymer blends are widely used in adhesion, colloidal stability, the design of composite and biocompatible materials, and other areas. As the science and technology of polymer blends advances, an increasing number of polymer blend systems and applications continue to be developed. Functional Polymer Blends: Synthesis, Properties, and Performance presents the latest synthesis and characterization methodologies for generating polymer blend systems. This one-stop resource brings together both experimental and theoretical material, much of which has previously only been available in research papers. Featuring contributions by eminent international experts, the book: Reviews polymer blend systems Details miscibility enhancements in polymer blends through multiple hydrogen binding interactions Presents the component dynamics in polymer blend systems Discusses concepts of shape memory polymer blends Considers ethylene methyl acrylate (EMA) copolymer toughened polymethyl methacrylate (PMMA) blends Provides theoretical insights through molecular dynamics simulation studies for binary blend miscibility Reports on the conformation and topology of cyclic linear polymer blends (CLBs) Addresses strain hardening in polymer blends with fibril morphology Explores the modification of polymer blends by irradiation techniques Examines the directed assembly of polymer blends using nanopatterned chemical surfaces Combining background and advanced information on technologies, methods, and applications, this practical reference is a must-have for researchers and industry professionals as well as students in materials science, chemistry, and chemical and surface engineering.

With contributions from noted laboratory scientists, professors, and engineers, Hydrogen Energy and Vehicle Systems presents a new comprehensive approach for applying hydrogen-based technologies to the transportation and electric power generation sectors. It shows how these technologies can improve the efficiency and reliability of energy and transportation systems. The book's interdisciplinary approach to sustainable energy systems disproves common misconceptions regarding hydrogen technologies and demonstrates that hydrogen technologies are a viable part of a sustainable, stable, and secure energy infrastructure. The book discusses intelligent energy management schemes for hydrogen energy and vehicle systems, safety and environmental science related to hydrogen technologies, and the infrastructure required for safe, renewable hydrogen options. A clear and up-to-date resource on hydrogen systems, this work provides a balanced presentation of theoretical/technical and application aspects of hydrogen technologies. It presents all stakeholder perspectives and connects hydrogen technology through proper systems analysis and integration, covering both quantitative and qualitative factors.

Advances in Industrial Heat Transfer presents the basic principles of industrial heat transfer enhancement. Serving as a reference and guide for future research, this book presents a complete approach, from redesigning equipment to the use of nanofluids in industry. Based on the latest methods of the experiment and their interpretation, this book presents a unified conception of the industrial heat transfer process and procedures which will help decrease global energy consumption. Containing both theoretical and practical results, the book uses text, pictures, graphs, and definitions to illustrate points and highlight concepts.

Chemicals from Biomass: Integrating Bioprocesses into Chemical Production Complexes for Sustainable Development helps engineers optimize the development of new chemical and polymer plants that use renewable resources to replace the output of goods and services from existing plants. It also discusses the conversion of those existing plants into facilities that are based on renewable resources that may require nonrenewable resource supplements. Relying on extensive reviews of biomass as feedstock and the production of chemicals from biomass, this book identifies and illustrates the design of new chemical processes (bioprocesses) that use renewable feedstock (biomass) as raw materials. The authors show how these new bioprocesses can be integrated into the existing plant in a chemical production complex to obtain the best combination of energy-efficient and environmentally acceptable facilities. This presented methodology is an essential component of sustainable development, and these steps are essential to achieving a sustainable chemical industry. The authors evaluate potential bioprocesses based on a conceptual design of biomass-based chemical production, and they use Aspen HYSYS (R) and Aspen ICARUS (R) to perform simulations and economic evaluations of these processes. The book outlines detailed process designs created for seven bioprocesses that use biomass and carbon dioxide as feedstock to produce a range of chemicals and monomers. These include fermentation, transesterification, anaerobic digestion, gasification, and algae oil production. These process designs, and associated simulation codes, can be downloaded for modification, as needed. The methodology presented in this book can be used to evaluate energy efficiency, cost, sustainability, and environmental acceptability of plants and new products. Based on the results of that analysis, the methodology can be applied to other chemical complexes for new bioprocesses, reduced emissions, and energy savings.

Particle Technology and Applications presents the theoretical and technological background of particle science and explores up-to-date applications of particle technologies in the chemical, petrochemical, energy, mechanical, and materials industries. It looks at the importance of particle science and technology in the development of efficient chemical processes and novel functional materials. With peer-reviewed chapters written by a select group of academic and industry experts, the book provides examples of particle technology and its advanced industrial applications. It includes the necessary scientific background of particle technology as well as relevant technological details of the application areas. This helps readers grasp specific details of the applied technology, since the advanced particle technology can directly or synergistically have an impact on outcomes, such as the development of a targeted functional material, enhancement of existing processing techniques, and modification of the properties of existing materials. Presenting a consistent scientific treatment of all topics, this comprehensive yet accessible book covers a variety of practical applications and relevant theoretical foundation of particle science and technology. It will help readers tackle new challenges in process and product development and create new methodologies in the clean technology sector.

A practical handbook rather than merely a chemistry reference, Szycher's Handbook of Polyurethanes, Second Edition offers an easy-to-follow compilation of crucial new information on polyurethane technology, which is irreplaceable in a wide range of applications. This new edition of a bestseller is an invaluable reference for technologists, marketers, suppliers, and academicians who require cutting-edge, commercially valuable data on the most advanced uses for polyurethane, one of the most important and complex specialty polymers. internationally recognized expert Dr. Michael Szycher updates his bestselling industry "bible" With seven entirely new chapters and five that are revised and updated, this book summarizes vital contents from U.S. patent literature-one of the most comprehensive sources of up-to-date technical information. These patents illustrate the most useful technology discovered by corporations, universities, and independent inventors. Because of the wealth of information they contain, this handbook features many full-text patents, which are carefully selected to best illustrate the complex principles involved in polyurethane chemistry and technology. Features of this landmark reference include: Hundreds of practical formulations Discussion of the polyurethane history, key terms, and commercial importance An in-depth survey of patent literature Useful stoichiometric calculations The latest "green" chemistry applications A complete assessment of medical-grade polyurethane technology Not biased toward any one supplier's expertise, this special reference uses a simplified language and layout and provides extensive study questions after each chapter. It presents rich technical and historical descriptions of all major polyurethanes and updated sections on medical and biological applications. These features help readers better understand developmental, chemical, application, and commercial aspects of the subject.

BIOFUEL EXTRACTION TECHNIQUES The energy industry and new energy sources and innovations are rapidly changing and evolving. This new volume addresses the current state-of-the-art concepts and technologies associated with biofuel extraction technologies. Biofuels are a viable alternative to petroleum-based fuel because they are produced from organic materials such as plants and their wastes, agricultural crops, and by-products. The development of cutting-edge technology has increased the need for energy significantly, which has resulted in an overreliance on fossil fuels. Renewable fuels are an important subject of research because of their biodegradability, eco-friendliness, decrease in greenhouse gas (GHG) emissions, and favorable socioeconomic consequences to counteract imitations of fossil fuels. Different extraction techniques are used for the production of biofuel from renewable feedstocks. A good example is biodiesel, a promising biofuel which is produced by transesterification of plant-based oils. Extraction of oil includes traditional methods, solvent extraction, mechanical extraction, microwave-assisted and ultrasonic-assisted methods. Many innovative techniques are also used to overcome the limitations of conventional methods. Microwave-assisted and ultrasonic-assisted are some of the new techniques which include the pre-treatment of the raw material using either ultrasonic waves or radio waves which helps in increasing the efficiency of the extraction of oil and improves the final quality of the oil. Written and edited a team of experts in the field, this exciting new volume covers all of these technologies with a view toward giving the engineer, scientist, or other professional the practical solutions for their day-to-day problems. It also contains the theory behind the practical applications, as well, making it the perfect reference for students and engineers alike. Whether for the veteran engineer or scientist, the student, or a manager or other technician working in the field, this volume is a must-have for any library.

Foam fractionation is a separation process in which proteins and other amphipathic species adsorb to the surface of bubbles. The bubbles are then removed from the solution in the form of foam at the top of a column. Due to its cost-effectiveness, foam fractionation has the potential for rapid commercial growth, especially in biotechnology. To assist in the widespread adoption of this highly affordable yet powerful process, Foam Fractionation: Principles and Process Design: Provides a systematic explanation of the underlying physics of foam fractionation Discusses the fundamentals of molecular adsorption to gas liquid interfaces and the dynamics of foam Describes foam fractionation process intensification strategies Supplies design guidance for plant-scale installations Contains the latest knowledge of foam fractionation transport processes Presents a case study of the world's largest commercial foam fractionation plant producing the food preservative Nisin Foam Fractionation: Principles and Process Design capitalizes on the authors' extensive practical experience of foam fractionation and allied processes to give process engineers, industrial designers, chemical engineers, academics, and graduate students alike a greater understanding of the mechanistic basis and real-world applications of foam fractionation.

The text highlights the importance of achieving a safe and healthy working environment in the food and beverage processing industry. It provides information on food and beverage manufacturing disease, injury management, safer steps for employees to get back to work, discusses food security, safety, biosecurity, defense food safety, and quality including food adulteration. * Discusses fundamentals of occupational health and safety in the food and beverage industry. * Highlight standards and legislations as related to occupational health and safety for food and beverage processing sectors. * Covers hazards, elements, accident prevention, various hazards present in food and beverage sectors, and their disease and injury management. * Explores ethical issues in agri-food processing sectors and their effects on sustainability. * Introduces importance, organization, and management for food and beverage processing sectors to prevent losses. The text is primarily written for professionals in the fields of occupational health and safety, food engineering, chemical engineering, and process engineering.

This unique atlas presents the recorded spectrum of CH3OH, the main isotopic species of methanol, in the range 28-1258 cm-1. The spectral plot is accompanied by a list of all currently assigned rotation-torsion-vibration lines in the absorption spectrum of methanol. The list of nearly 35,000 transitions spans all of the known microwave transitions, as well as the region of coincidence with CO2 laser emissions.

In the process industry, shutdown and turnaround costs are responsible for an excessive amount of maintenance expenses. Process Plants: Shutdown and Turnaround Management explores various types of shutdowns, presents recommendations for better management, and offers feasible solutions to help reduce overheads. Because turnaround management is the largest maintenance activity, plant turnaround is the focal point of this text. The book details a plan to lengthen the interval between turnarounds, and curtail costs in process production management by at least 30 percent. This practical guidebook provides a thorough study of shutdown management, discusses different types of shutdown and managing events (emergency, unplanned, planned, and turnaround), and covers all aspects of plant turnaround management including startup, shutdown, and maintenance. It describes the five phases of shutdown management-initiating, planning, executing, controlling, and closing. It contains specific principles and precautions for successful shutdown planning, and highlights many aspects including turnaround philosophy, planning and scheduling, estimation, contractor management, execution, safety management, managing human resources, and post shut down review. Process Plants: Shutdown and Turnaround Management also includes topical information that readers can successfully apply to future shutdown projects. It is suitable for industry professionals and graduate students.

The use of photoinitiators in the UV curing process shows remarkable possibilities in myriad applications. Highlighting critical factors such as reactivity, cure speeds, and application details, Industrial Photoinitiators: A Technical Guide is a practical, accessible, industrially oriented text that explains the theory, describes the products, and outlines the practice in simple language for the novice and expert alike. The basics of UV light The book begins by examining the nature of UV light and the types of commercial UV lamps that are available. It discusses the light absorption process and the excited states that are produced by the photoinitiator prior to the production of radicals. Next, the book examines the structure of the photoinitiator and the mechanism by which a reactive species is formed, along with the deactivating processes that inhibit the various photophysical and photochemical steps that occur as radicals are produced. Commercial photoinitiators Providing a list of companies and suppliers, the author explores the distinct groups of commercial photoinitiators and the variations in their structure. He describes the factors that determine which photoinitiators should be chosen for a particular application and how the different types are used. He also explains the reasons why a cured coating may display yellowing and describes the use of stabilizers to reduce the yellowing effect. Cationic curing Exploring a small but growing area of interest in the UV curing industry, the book concludes by discussing cationic curing and examines the different scope of parameters and different chemistry involved. It also describes factors that affect the use of cationic photoinitiators. Based on more than 30 years of experience working with photoinitiators, W. Arthur Green offers

Since the 1990s the synthetic community has shown a growing interest in the development of catalytic reactions that employ entirely organic catalysts - so-called 'organocatalysts'. With the current emphasis on green chemistry throughout the chemical industry, organocatalysis has become indispensible. In spite of this growth and recognition, there can be a misconception that organocatalysts are only based on nitrogen-containing functional groups (amines, ureas, and quaternary ammonium salts, for example), and are only useful for asymmetric reactions. Nonnitrogenous Organocatalysis shows that the umbrella of organocatalysis covers other main group elements besides nitrogen, and the coverage is not just limited to asymmetric methods. Many of the catalysts and mechanisms discussed may not have a viable asymmetric variant or cannot be rendered asymmetric at all. This does not make them any less useful, as illustrated in this book.

Respiratory protection includes devices and management techniques for keeping people safe from hazardous materials. This handbook presents the state-of-the-art in respiratory protection technology as well as best management practices for work centers. Included are topics relevant to industry, government, and healthcare that provide guidance and tools for ensuring the best possible protection for workers. Most books on this topic are at least 20 years old. Research, technology and management techniques have advanced over the past two decades. This new handbook is needed to provide updated information relevant to today's occupational needs for industrial hygiene and safety professionals.

This book represents the first comprehensive reference volume available on subsurface transport and fate processes. The volume is organized into four sections covering the basics of contaminant properties and how they affect transport and fate, the fundamental processes affecting subsurface transport and fate of contaminants, applications of transport and fate information to various contaminant types, and utilization of transport and fate information for predicting contaminant behavior. Specific topics such as traditional hydrodynamic processes of advection and dispersion, facilitated transport and contaminant flushing, and individual ground water contaminants are also explored in detail. Subsurface Transport and Fate Processes is ideal for environmental and ground water consultants, regulatory agency personnel, and educators in geology, hydrogeology, civil engineering, and environmental engineering.

Omitting complicated chemistry concepts, Polyurethane Casting Primer presents practical details on the casting of polyurethane products to assist readers in their daily work. It covers fundamental methods, explores hands-on design and production topics, and keeps theory to a minimum. The book fully explains casting and allied processes. Starting from a "bucket and paddle mix" open pour, postcuring machining, bonding, and painting, it discusses how to produce quality products continuously. The author describes the necessary precautions for maintaining the health and safety of workers. He covers the properties of polyurethane systems, the tests and results of polyurethanes commonly used in compression, and the correct grade and processing of polyurethanes for meeting customer requirements. He also reveals how to fix issues such as molding problems and premature end of life. The versatility of polyurethane enables a wide range of applications, from simple, noncritical parts to vital engineering products. This book guides manufacturers in designing and producing polyurethane products. Batch calculations are available for download at www.crcpress.com

The explosion of plastic material development continues to generate a proliferation of conversion processes and variants of these methods. Unfortunately, most books on plastics conversion focus on a single process, such as injection molding, limiting their usefulness to readers without prior knowledge of the field. Few, if any, single-source texts adequately describe and compare each of the plastic conversion processes together. Plastic Conversion Processes: A Concise and Applied Guide addresses that need. It provides a basic overview of each of the seven major conversion processes, which account for the creation of more than 97 percent of all plastics products today. This detailed guide assembles and integrates the wealth of information scattered throughout various literature, to provide a basic yet complete illustration of plastic conversion processes. Learn Methods to Compare, Evaluate, and Select the Best Process for Your Product This book is unique in that it employs an all-encompassing approach, offering more than a mere overview of basic theory and application related to each major process. Chapters begin with a process-attribute table to serve as a quick guide, and then briefly describe a particular conversion process. To ensure comprehensive understanding of each method and how it works, sections include a short history and detailed explanation of the particular equipment, tooling, and materials used, as well as general piece part design guidelines and case studies gleaned from real-life experience. There is a plastic term for every letter of the alphabet, making it one of the most complex fields in science. A "quick reference" section at the end of the book includes an exhaustive collection of more than 350 terms, definitions, acronyms, and a key process characteristics comparison chart. Supplemented with photos, diagrams, and illustrations t

Hazardous energy present in systems, machines, and equipment has injured, maimed, and killed many workers. One serious injury can stop the growth of your business in its tracks. Management of Hazardous Energy: Deactivation, De-Energization, Isolation, and Lockout provides the practical tools needed to assess hazardous energy in equipment, machines, and systems, and covers how to manage hazardous energy through elimination or control in order to ensure worker safety and regulatory compliance. Written in plain English with a minimum of jargon, this book provides safety professionals with the knowledge they need to interact with specialists, designers, and engineers to ensure that appropriate and necessary protocols and safety practices and tools are put into place for assessing the dangers and steps taken to eliminate or control exposure to hazardous energy when needed. Approaching the subject from the bottom up, the author starts at the workplace level, to ensure that the right actions happen for the right reasons. The book explains a protocol for describing the flow of energy, including transformation and/or storage; for capturing the logic of decisions about control, including failure analysis and contingency planning; and ultimately for creating procedures that are technically sound and defensible. Creating simple procedures for ensuring worker safety and regulatory compliance, the book offers US and international strategies for hazardous energy management and contains examples to illustrate the application of concepts to specific areas.

Provides insights into the various aspects of microbial genomics and biotechnology for environmental cleanup In recent years, the application of genomics to biodegradation and bioremediation research has led to a better understanding of the metabolic capabilities of microorganisms, their interactions with hazardous and toxic chemical compounds, and their adaptability to changing environmental conditions. Genomics to Bioremediation: Principles, Applications, and Perspectives provides comprehensive and up-to-date information on cutting-edge technologies and approaches in bioremediation and biodegradation of environmental pollutants. Edited by prominent researchers in the field, this authoritative reference examines advanced genomics technologies, next-generation sequencing (NGS), and state-of-the-art bioinformatics tools while offering valuable insights into the unique functional attributes of different microbial communities and their impact on the removal of chemical contaminants. Each chapter includes numerous high-quality illustrations, detailed tables, extensive references, and step-by-step descriptions of various microbial metabolic pathways of degradation and biotransformation of environments containing various inorganic, metallic, organometallic, and organic hydrocarbon contaminants. Describes methodologies and underlying theory for the remediation, detoxification, and degradation of contaminated environments Covers new genomics technologies that address nutrient removal, resource recovery, and other major trends in environmental cleanup Highlights recent advances in microbial biotechnological approaches including the latest description of the relationship between microbes and the environment focusing on their impact on ecosystem services. Offers perspectives on energy saving, production, sustainability, and community involvement Discusses current challenges and future directions in the field of bioremediation Genomics to Bioremediation: Principles, Applications, and Perspectives is an essential resource for biochemical and environmental engineers, environmental microbiologists, academic researchers, process and treatment plant managers, policymakers, and industry professionals working in the areas of microbial degradation, bioremediation, and phytoremediation.

The equations used to describe dynamic properties of physical systems are often nonlinear, and it is rarely possible to find their solutions. Although numerical solutions are impractical and graphical techniques are not useful for many types of systems, there are different theorems and methods that are useful regarding qualitative properties of nonlinear systems and their solutions-system stability being the most crucial property. Without stability, a system will not have value. Nonlinear Systems Stability Analysis: Lyapunov-Based Approach introduces advanced tools for stability analysis of nonlinear systems. It presents the most recent progress in stability analysis and provides a complete review of the dynamic systems stability analysis methods using Lyapunov approaches. The author discusses standard stability techniques, highlighting their shortcomings, and also describes recent developments in stability analysis that can improve applicability of the standard methods. The text covers mostly new topics such as stability of homogonous nonlinear systems and higher order Lyapunov functions derivatives for stability analysis. It also addresses special classes of nonlinear systems including time-delayed and fuzzy systems. Presenting new methods, this book provides a nearly complete set of methods for constructing Lyapunov functions in both autonomous and nonautonomous systems, touching on new topics that open up novel research possibilities. Gathering a body of research into one volume, this text offers information to help engineers design stable systems using practice-oriented methods and can be used for graduate courses in a range of engineering disciplines.

Biomass to Renewable Energy Processes, Second Edition, explains the theories of biological processes, biomass materials and logistics, and conversion technologies for bioenergy products such as biogas, ethanol, butanol, biodiesel, and synthetic gases. The book discusses anaerobic digestion of waste materials for biogas and hydrogen production, bioethanol and biobutanol production from starch and cellulose, and biodiesel production from plant oils. It addresses thermal processes, including gasification and pyrolysis of agricultural residues and woody biomass. The text also covers pretreatment technologies, enzymatic reactions, fermentation, and microbiological metabolisms and pathways.

Biohydrogen Production: Fundamentals and Technology Advances covers the fundamentals of biohydrogen production technology, including microbiology, biochemistry, feedstock requirements, and molecular biology of the biological hydrogen production processes. It also gives insight into scale-up problems and limitations. In addition, the book discusses mathematical modeling of the various processes involved in biohydrogen production and the software required to model the processes. The book summarizes research advances that have been made in this field and discusses bottlenecks of the various processes, which presently limit the commercialization of this technology. The authors also focus on the process economy, policy, and environmental impact of this technology, since the future of biohydrogen production depends not only on research advances, but also on economic considerations (the cost of fossil fuels), social espousal, and the development of H2 energy systems. The book describes the fundamentals of this technology interwoven with more advanced research findings. Further reading is suggested at the end of each chapter. Since the beauty of any innovation is its applicability, socioeconomic impact, and cost energy analysis, the book examines each of these points to give you a holistic picture of this technology. Illustrative diagrams, flow charts, and comprehensive tables detailing the scientific advancements provide an opportunity to understand the process comprehensively and meticulously. Written in a lucid style, the book supplies a complete knowledge bank about biohydrogen production processes.