Ideal for practicing physicians and residents who are preparing to take the American Board of Family Medicine (ABFM) initial or continuing exam, Swanson's Family Medicine Review: A Problem-Oriented Approach, 9th Edition, provides more than 2,500 questions in a practical case study format. This bestselling review tool reflects the clinical disciplines as tested by the ABFM, and also serves as an excellent resource for residents' case-based RISE exams. Fully updated and easy to use, it covers recent developments and current information in family medicine, providing the assistance you need to ensure success on the ABFM exam. Uses realistic case problems as a basis for questions on diagnosis and management, with detailed answers that explain both correct and incorrect responses. Prepares you for the ABFM's Certificates of Added Qualifications (CAQs) in adolescent medicine, geriatric medicine, hospice and palliative medicine, pain medicine, sleep medicine, and sports medicine, as well as the upcoming CAQ in hospital medicine. Reflects meticulous updating for accuracy and complete coverage, including more questions in key areas for newer CAQs. Includes tips and tricks for passing the board exam, clinical algorithms throughout, summaries at the end of each case, and case management problems that suggest the ideal diagnostic work-up. Allows you to earn up to 75 CME Credits online through Rutgers Robert Wood Johnson Medical School. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices, as well as answer questions interactively and check your answers on any electronic platform.

This brand new Lecture Notes title provides the core biomedical science study and revision material that medical students need to know. Matching the common systems-based approach taken by the majority of medical schools, it provides concise, student-led content that is rooted in clinical relevance. The book is filled with learning features such as key definitions and key conditions, and is cross-referenced to develop interdisciplinary awareness. Although designed predominantly for medical students, this new Lecture Notes book is also useful for students of dentistry, pharmacology and nursing. Biomedical Science Lecture Notes provides: * A brand new title in the award-winning Lecture Notes series * A concise, full colour study and revision guide * A 'one-stop-shop' for the biomedical sciences * Clinical relevance and cross referencing to develop interdisciplinary skills * Learning features such as key definitions to aid understanding

This 8-volume set provides a systematic description on 8,350 active marine natural products from 3,025 various kinds of marine organisms. The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with 264 structural types are developed as well. The 8th volume mainly illustrates the molecular formula and structures of peptides and other products.

1 Kombinatorische Synthese.- 1.1 Einfuhrung.- 1.2 Der Prozess der Wirkstofffindung.- 1.3 Was ist kombinatorische Synthese?.- Literatur.- 2 Bibliothekssynthese an Harzkoernern.- 2.1 Festphasenchemie.- 2.2 Harzkoerner.- 2.2.1 Quervernetztes Polystyren.- 2.2.2 Polyamidharze.- 2.2.3 Poroeses Glaskorn.- 2.2.4 TentaGel-Harz.- 2.2.5 Magnetische Beads.- 2.3 Beschleunigung der Peptidsynthese.- 2.4 Split & Mix-Bibliothekssynthese.- 2.5 Peptidbibliotheken.- 2.6 Positional Scanning.- 2.7 Orthogonale kombinatorische Bibliotheken.- 2.8 Bibliotheksnomenklatur.- 2.9 Schlussbemerkung.- Literatur.- 3 Andere Festphasen.- 3.1 Bibliotheken an Multipins.- 3.2 Bibliotheken an Winks.- 3.3 Bibliotheken an laminaren Festphasen.- 3.3.1 Lichtgesteuerte Parallelsynthese.- 3.3.2 Papier.- 3.3.3 Laminare Polymere.- Literatur.- 4 Bibliothekssynthese in Loesungsphase.- 4.1 Einleitung.- 4.2 Parallelsynthese in Loesung.- 4.3 Indizierte kombinatorische Bibliotheken.- 4.4 Templat-basierte Bibliotheken.- 4.5 Kombinatorische Synthese in Flussigphase.- 4.6 Kombinatorische Chemie an Dendrimertragern.- 4.7 Bibliotheken in Loesungsphase mit Flussig-flussig-Reinigung.- 4.8 Chemie in fluorierter Loesung.- 4.9 Chemie in Loesung mit Festphasenreagenzien.- 4.10 Chemie in Loesung mit Harzabfangreaktion.- 4.11 Chemie in Loesung mit polymeren Reagenzien.- 4.12 Zusammenfassung.- Literatur.- 5 Codierte kombinatorische Synthese.- 5.1 Einleitung.- 5.2 Voraussetzungen fur die Codierung.- 5.3 Beispiele markierter Bibliotheken.- 5.3.1 Oligonucleotid-Tags.- 5.3.2 Peptid-Tags.- 5.3.3 Halogenaromatische Tags.- 5.3.4 Sekundare Amine-Tags.- 5.3.5 Isotopencodierung.- 5.4 Hochfrequenz-Tags.- 5.5 Laseroptische Codierung.- 5.6 Fluorophor-Codierung.- 5.7 Zusammenfassung.- Literatur.- 6 Jenseits von Peptidbibliotheken.- 6.1 Die Entwicklung von Nicht-Peptidbibliotheken.- 6.2 Oligonucleotidbibliotheken.- 6.3 Oligosaccharide.- 6.4 Andere Oligomere.- 6.4.1 Unnaturliche Peptide.- 6.4.2 Bibliotheken aus Bibliotheken.- 6.4.3 Oligocarbamate.- 6.4.4 Oligoharnstoffe.- 6.4.5 Peptidosulfonamide.- 6.4.6 Azatide.- 6.4.7 Polyisoxazoline.- 6.4.8 Peptidylphosphonate.- 6.5 Chiron-Peptoide.- 6.6 Zusammenfassung.- Literatur.- 7 Bibliothekssynthesen an Festphasen.- 7.1 Linker.- 7.1.1 Carbonsaure-Linker.- 7.1.2 Carbonsaureamid-Linker.- 7.1.3 Alkohol-Linker.- 7.1.4 Amin-Linker.- 7.1.5 Spurlose Linker.- 7.1.6 Lichtspaltbare Linker.- 7.2 Die Entwicklung der Festphasenchemie.- 7.3 Ausgewahlte Beispiele der Festphasenchemie.- 7.3.1 Palladium-katalysierte Kopplungen.- 7.3.2 Mitsunobu-Kopplungen.- 7.3.3 Heterocyclische Synthese.- 7.3.4 Cycloadditionen.- 7.3.5 Enolat-Alkylierungen.- 7.3.6 Die Ugi-Reaktion.- 7.4 Zusammenfassung.- Literatur.- 8 Analyse der Chemie und der Produkte.- 8.1 Analyse des Erfolgs einer Synthese.- 8.2 IR-Analyse des Beads.- 8.3 Festphasen-NMR.- 8.3.1 Kohlenstoff- 13-NMR.- 8.3.2 Fluor-19-NMR.- 8.3.3 Phosphor-31-NMR.- 8.3.4 Magic-Angle-Spinning-NMR.- 8.4 Massenspektrometrie.- 8.4.1 Die Analyse der Festphasen-Chemie.- 8.4.2 Die Identifizierung aktiver Bibliothekskomponenten.- Literatur.- 9 Anwendungen der kombinatorischen Chemie.- 9.1 Einfluss der kombinatorischen Chemie auf die Wirkstoff findung.- 9.2 Virtuelle Bibliotheken und kombinatorische Chemie.- 9.3 Kombinatorische Chemie: eine Schlussbetrachtung.- Literatur.- Ausgewahlte Fachwoerter Englisch-Deutsch.

This volume dealing with the male body in the iconography of fascism reflects an ambition rather than an achievement. The supremacy of the global fascist superman never became a reality but was certainly an intention. This work explores the use of the image of the male body for this purpose in European, American and Asian fascism of varying degrees and various interpretations, and the differences and similarities involved. Among the similarities isthe fact that sport in all the cases in this volume was at the centre of the induction of the male body (and mind) into martial self-sacrifice. Sport was an important part of fascist socialization. The reasons are not hard to find. Sport develops muscle and muscle is equated with power - literally and metaphorically. War, the essence of fascism, demands physical fitness and sport helps promote this fitness. Competitive sport can help develop attitudes of aggression and aggression is essential in war.

This volume dealing with the male body in the iconography of fascism reflects an ambition rather than an achievement. The supremacy of the global fascist superman never became a reality but was certainly an intention. This work explores the use of the image of the male body for this purpose in European, American and Asian fascism of varying degrees and various interpretations, and the differences and similarities involved. Among the similarities isthe fact that sport in all the cases in this volume was at the centre of the induction of the male body (and mind) into martial self-sacrifice. Sport was an important part of fascist socialization. The reasons are not hard to find. Sport develops muscle and muscle is equated with power - literally and metaphorically. War, the essence of fascism, demands physical fitness and sport helps promote this fitness. Competitive sport can help develop attitudes of aggression and aggression is essential in war.

Shows cranial nerves and vessles in the base of brain. Also provides lateral and sagittal section views of the arteries of the brain. Illustrates lobes, limbic system, ventricles of the brain, coronal section, Circle of Willis, circulation of cerebrospinal fluid (CSF), somatotopic organization of the cerebrum and meninges of the brain. Size is 20" W by 26" H.

Jerry Stannard assembled a legendary collection of materials on the history of botany from Homer to Linnaeus, and his mastery of the field was acknowledged as incomparable. However, his work was sadly cut short by his death, and so did not result in the ultimate synthesis he envisioned; the present volume, and its companion, Herbs and Herbalism in the Middle Ages and the Renaissance, bring together his important output in articles and studies. In this selection of papers on pharmacy and medical botany, from the classical period to 1500, Stannard combined philological expertise with the scientific perspective of modern pharmacology to measure the descriptive accuracy and therapeutic efficacy of Materia Medica from Hippocrates to the Renaissance. His sources included not only the obvious technical treatises but also works of literature and the traditions of folklore especially in Italy. Three studies of the scholastic botany of Albertus Magnus form the centrepiece of the collection, and the detailed indexes cover both common and scientific names of plants.

Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques. This book is ideal for researchers in the areas of biochemistry, medicine, and pharmacology.

Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.

During the past decade, modern high-performance liquid chromatography (HPLC) utilization has expanded greatly, especially in the quality control of pharmaceutical products in drug quality control laboratories. This book provides an extensive collection of technical information about HPLC-Columns (physicochemical properties and chromatographic characteristics), from various manufacturers, and helps analysts to decide on the ideal approach for their analysis according to the requirements of drug manufacturers specifi cations and the desired Pharmacopeia. In addition, the authors give practical advice on how to prepare mobile phases, choose a suitable detector, and set up an HPLC analysis. This book is comprehensive for the average professional or technician who plans to work with modern HPLC. This book is useful for most Drug Quality Control Laboratories where modern HPLC is utilized. Following a hands-on approach, the book gives key insights into the pharmaceutical applications of HPLC and the latest requirements of the major regulatory agencies such as ICH, FDA, or USP.

Biochemistry Behind the Symptoms takes a problem-based approach to understanding and applying biochemistry for superior clinical outcomes. Organized around the common symptoms encountered by clinicians, this engaging text clarifies the connections between foundational science and clinical manifestations to help users form confident diagnoses throughout their clerkship and beyond. Each chapter explores the biochemical concepts behind underlying causes and demonstrates their ties to presenting symptoms through 5 realistic patient cases. Accompanying questions encourage discussion and guide users in building accurate differential diagnoses. Ideal for peer-to-peer learning environments or independent study, this practical approach strengthens users' application of fundamental knowledge and ensures the long-term retention essential to clinical success. 50 Patient Cases emphasize the biochemical concepts behind common patient symptoms through problem-based learning. Clinical Impression sections encourage critical thinking and train students step by step in building effective differential diagnoses. Basic Science Correlations in each Patient Case clarify the biochemical concepts underlying diagnosis with an engaging question-and-answer format. High-Yield Concepts summarized after each Patient Case reinforce students' comprehension of essential chapter concepts. Digital Animations immerse students in biochemical processes to enrich their understanding and diagnostic confidence.

The book presents, in a unified manner, various crystallization design methods. It discusses in detail the geometric framework for representing complex phase behavior involving multiple solutes, enantiomers, hydrates, compounds, polymorphs, and solid solutions through visualization of high-dimensional phase diagrams. It also describes how the impact of transport processes is accounted for using kinetically controlled process paths.

Protein has become one of the most misunderstood nutrients. Protein is broken down during digestion and later restructured to make the proteins and enzymes the body needs for life. Protein consists of amino acids, which are used in the construction of neurotransmitters, hormones, muscle and other tissues. This User's Guide demystifies Protein and Amino Acids and explains how readers can use them to enhance their health.

Single-Use Technology (SUT) is the first comprehensive publication of practical considerations for each stage of the implementation process of SUT, and covers the selection, specification, design and qualification of systems to meet end-user requirements. Having become readily available for all processing operations within the biopharmaceutical industry, SUT has the potential to reduce capital costs, improve plant throughput and reduce the risk of cross-contamination. However, there are no clear guidelines to aid the end-user on implementation of these technologies into a validated, good manufacturing practice (GMP) environment. This book presents approaches for the implementation within various end-user facilities and systems, SUT within regulatory frameworks (ICH Q8, Q9, Q10 and GMP), standardisation and assessment strategies, specifation of user requirements and SUT design, risk assessment and evaluation as well as qualification for different SUT types.

One of our most popular charts Shows right lateral view of the vertebral column with markings to show location of atlas & axis, cervical, thoracic & lumbar vertebrae, and sacrum and coccyx. Provides various views of atlas & axis, second lumbar vertebra, fifth cervical vertebra, seventh and eleventh thoracic vertebrae, and sacrum and coccyx. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

"Organic Trace Analysis" presents the basics of trace analysis, from sample preparation to the measurement: Students are introduced to statistical evaluation, quality control technologies, sampling and preparation of organic traces, as well as to enrichment and separation of samples. Spectroscopic techniques as chromatography, capillary electrophoresis, mass spectrometry, and receptor-based bioanalysis are presented in detail.

This book moves away from the frameworks that have traditionally guided ethical decision-making in the Western clinical setting, towards an inclusive, non-coercive and, reflective dialogic approach to moral decision-making. Inspired in part by Jurgen Habermas's discourse theory of morality and principles of communicative action, the book offers a proportionist approach as a way of balancing out the wisdom in traditional frameworks, set in the actual reality of the clinical situation at hand. Putting this approach into practice requires having a conversation, a dialogue or a discourse, with collaboration amongst all the stakeholders. The aim of the dialogue is to reach consensus in the decision, via mutual understanding of the values held by the patient and others whom they see as significant. This book aims to underscore the moral philosophical foundations for having a meaningful conversation. Life and Death Decision in the Clinical Setting is especially relevant in our contemporary era, characterised medically by an ever-increasing armamentarium of life-sustaining technology, but also by increasing multiculturalism, a multiplicity of faiths, and increasing value pluralism.

Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor. It covers a wide range of information, including data from 3 studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available. Although the A receptor is increasingly being recognized for 3 its increasing number of biological roles throughout the body and many A receptor 3 ligands have proven useful in elucidating peripheral and central pathologies, many issues remain unresolved. Moreover, research activity in this field continues to grow exponentially, resulting in a constant flow of new information. The chapters in this book cover both basic science and the relevant applications and provide an authoritative account of the current status of the field. They have enabled my goal as editor to make "A Adenosine Receptors from Cell Biology to Pharmacology and 3 Therapeutics" an up to date, scientifically excellent, reference source, attractive to basic and clinical scientists alike, a reality. Detailed understanding of the physico-chemical aspects and molecular biology of the A receptor provides a solid basis for its future development as a target for 3 adenosine-based pharmacotherapies (Chapters 2 and 3).

Dirk Haller und Gabriele Hörmannsperger geben einen Überblick über die zentrale Rolle des Darms und seiner Bewohner für die Gesundheit und vermitteln zusätzlich einen ersten Eindruck von den komplexen und dynamischen Interaktionen zwischen D+armbakterien und Wirt. Denn Forschungsergebnisse der letzten Jahre weisen darauf hin, dass die lange unbeachteten Darmbakterien (intestinale Mikrobiota) eine unerwartet zentrale Rolle für die Aufrechterhaltung der Gesundheit einnehmen. Die Forschung beschäftigt sich aktuell intensiv damit, die Grundlagen für ein funktionierendes und gesundheitsförderndes mikrobielles Ökosystem zu identifizieren. Dieses Wissen kann zukünftig für die Entwicklung gezielter Maßnahmen zur Prävention und Therapie Mikrobiota-assoziierter Erkrankungen eingesetzt werden.

This series aims to update major areas of biological psychiatry and summarize important research conducted since the 1980s. It also highlights recent approaches that allow researchers to quantify normal and abnormal brain functions at a high level of precision.

The first insights into the site and mechanisms of RNA process- ing to functional mRNA in eukaryotic cells came from the group of Georgiev (Lukanidin et al. 1972) who demonstrated the association of rapidly labelled, heterogeneous nuclear RNA (hnRNA) with a limited number of specific proteins in the cell nucleus. These "informofers", i. e. packaged precursors of mRNA (pre-mRNA or hnRNA), are in a form presumably amenable to the action of nucleases. With the availability of better analytical techniques, the considerable heterogeneity of hnRNA associated proteins was revealed (Niessing and Sekeris 1970), suggesting a role that was more composite, rather than solely structural, for these proteins. Later studies investigated the RNA binding behavior of these proteins (Schenkel et al. 1988, 1989; Wilk et al. 1983). For a long time, the small nuclear RNAs, well characterized with respect to primary structure (reviewed by Reddy and Busch 1983), were naively ignored regarding their function. Several events then set the stage for a detailed study of the intricate mechanisms of the splicing process and other steps involved in hnRNA processing: (1) The demonstration of a second class of nuclear ribonucleoproteins (RNPs), composed of small nuclear RNAs (snRNAs) and another characteristic group ofheterogene- ous proteins (Lerner et al. 1980; Guialis et al. 1983); (2) the detec- tion of the association of snRNPs with hnRNPs by virtue of base pairing between hnRNA and snRNA (Flytzanis et al.

A comprehensive textbook that offers the right balance of Anatomy, Physiology, and Clinical coverage. Essentials of Human Anatomy & Physiology, 13th edition, Global edition by Marieb and Keller, is an essential guide in A & P, focusing on the most important topics in the field. Ideal for one-semester Anatomy and Physiology courses, this text combines short, easy-to-read chapters with accessible figures that you can understand and provides the high-quality content necessary to succeed in the course. This latest edition presents new study tools at the end of each chapter and digital resources to help you study more efficiently and remember the necessary details of the concepts introduced, along with an abundance of mnemonic cues to facilitate learning. Key features include: Clear and friendly writing style featuring familiar analogies you can easily memorise. Easy navigation with numbered sections and sub-sections throughout the book. End-of-chapter Summary Outlines helping you organise your studying more efficiently, followed by relevant questions. A Closer Look & Career Features sections covering key points in the book. Personalise your learning experience and improve results with Mastering (R) A&P. Mastering provides access to trusted content using customisable tools, features, and assessments built for today's digital learners. Pearson Mastering (R) A&P is not included. If you would like to purchase both the physical text and MasteringA&P, search for: 9781292401744 Essentials of Human Anatomy & Physiology, Global Edition, 13th Edition with MasteringA&P & eText The bundle consists of: 9781292401942 Essentials of Human Anatomy & Physiology, Global Edition, 13th Edition 9781292401775 Pearson Mastering A&P - Instant Access - for Essentials of Human Anatomy & Physiology, Global Edition, 13th Edition 9781292401782 PearsonA&P with Pearson eText - Instant Access - for Essentials of Human Anatomy & Physiology, Global Edition, 13th Edition This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content, which is especially relevant to students outside the United States.