Volume 1 of the series "Fundamentals of Medical Cell Biology" is devoted to evolutionary biology. This is presented in two parts: in the first, the structure and dynamics of RNA, DNA, and protein are dealt with. The second part is concerned with the origins and cellular basis of life.

We live in an unprecedented era of flourishing of scientific publishing. However, many professionals in the biomedical sciences find writing articles to be a daunting task. The book is meant to serve as a practical writing guide that covers the writing process from the project's inception until online distribution of the published article.The book covers the framework for constructing a scientific study into a coherent narrative that can later be easily translated into a written manuscript. The content of each article section in accordance with the IMRAD format is covered and many details for the construction of additional submission materials are provided. Characteristics of papers reporting on specific types of research are presented as well as article types other than the general full research article. The book is full of resources for additional reading and learning.There are many writing guides on the market. Most of them are general, cover a wide range of scientific writing, and are mainly aimed at students. This book is best suited for young professionals who are a few years out of school. They no longer enjoy the benefit of close mentoring by a thesis adviser or equivalent, but still lack the experience to lead writing projects on their own. Through her experience of teaching young professionals and editing their work, Dr Diskin has learned their unique set of needs and the book has been written in an attempt to address them. Dr Diskin addresses the reader in the second person, with an ever-supportive tone. Importantly, the practicalities of writing articles in today's interconnected environment are discussed throughout the book. Topics such as coordinating the writing in a multinational team, use of different types of software in the writing process and resources available online to support the writer are addressed in detail.Related Link(s)

The optical spectra of molecular membrane probes can be interpreted terms of the structure, dynamics, and the physiological state of the membrane. The general picture we have of membranes and of the properties of the proteins imbedded in them, has, arguably, emerged directly from probe studies over the last 20 years. This work is designed to make these techniques accessible to a broad audience of cell biologist. The techniques discussed revolve primarily around the fluorescence of membrane probes, but applications of light absorption and Raman scattering are included. In addition to reviews of the major applications, most chapters include information on required apparatus, experimental design, data analysis, and potential pitfalls.

This first volume contains data on amino acids which consists of the coefficients of solubility in water, heat capacities, entropies of formation, and heats of combustion. Specific gravity liquids, sucrose solution, CsCI solution isokinetic glycerol and sucrose gradients for density gradient centrifugation and the temperature dependence for select compounds are included.

Containing 45 papers written by outstanding international authors from 14 countries, this three-volume compendium brings together the elements needed to understand the factors which influence the utilization of amino acids. The wide-ranging topics include descriptions of metabolic pathways and mechanisms of the biological utilization of amino acids, as well as factors that influence amino acid bioavailability in enteral and parenteral nutrition. The use of amino acids to improve the quality and safety of the diet is presented. Also discussed are amino acid precursors of biogenic amines and the role of amino acids in atherosclerosis, cancer, and immunity. Scientists from many disciplines will benefit from this broad overview.

This book has been written in part with the aim of providing a text which will be useful in teaching the biochemical applications of spectroscopy. This book will be of particular use to the biochemist or biologist who does not have a background in spectroscopy, but desires to find out what sort of information spectroscopy can provide. Attention was limited to those techniques most frequently used, and which at present have the widest applications.

This book discusses urinalysis in clinical laboratory practice, including a historical overview, methods, future endeavours.

Presents short topics tied to numerical or conceptual ideas, reinforced with worked examples and questions Retaining the user-friendly style of the first edition, this text is designed to eliminate the knowledge gap for those life sciences students who have not studied chemistry at an advanced level. It contains new chapters on Water, covering the mole concept and colloids Gases, discussing pressure, gas laws, partial pressure, solubility of gases, and diffusion Metals in biology, including properties, oxygen carriers, biocatalysis, charge carriers, and toxicity The authors divide their analysis of carbon compounds into two chapters. One focuses exclusively on aliphatic carbon compounds, while the other provides a greatly expanded exploration of aromatic carbon compounds, isomerism, amines and amino acids, including benzene, aromaticity, types of isomerism, and absolute configuration. With a current examination of organic and biological reactions, this instructional volume also features end-of-chapter questions and provides a solutions manual for qualified instructors.

Fundamentals of Biochemical Calculations, Second Edition demystifies the fundamental calculations used in modern biochemistry, cell biology, and allied biomedical sciences. The book encouragesbothundergraduates and scientists to develop an understanding of the processes involved in performing biochemical calculations, rather than rely on memorized formulae. Detailed calculation steps, useful comments, and mathematical hints enhance solved problems throughout... Encouraging the use of the Ratio Method, the author draws attention to its applicability to a wide variety of biochemistry problems with logical consistency and intuitive ease. This entirely revised and updated second edition introduces three new chapters with coverage of laboratory-oriented calculations and data presentation, calculations relating to the emerging techniques in DNA and molecular biology, and applying the Ratio Method to pharmaceutical calculations. New edition adds questions and extra tips in every chapter to help students perform biochemical calculations on their own! By strengthening their understanding of mathematical logic and problem solving skills, Fundamentals of Biochemical Calculations, Second Edition enables students and biochemists to explore a wider range of real-world applications with the ability to tackle increasingly complex problems in biochemistry and related fields.

Ideal for medical students studying basic sciences, Get ahead! Basic Sciences: 500 SBAs covers anatomy, physiology, pharmacology and biochemistry, including clinical-based themes. Questions are accompanied by explanations to guide further review, making this, along with the companion EMQ volume, an essential resource for your basic sciences exams.

Ideal for medical students studying basic sciences, Get ahead! Basic Sciences: 100 EMQs covers anatomy, physiology, pharmacology and biochemistry, including clinical-based themes. Questions are accompanied by explanations to guide further review, making this, along with the companion SBA volume, an essential resource for your basic sciences exams.

The mechanism of information transfer between cells is the subject of Introduction to Signal Transduction. Until recently various aspects of signaling by hormones were studied (and taught) under the subject of endocrinology, and signaling by neurotransmitters was the subject of neurochemistry. With growing awareness of the many similarities between hormonal and neurotransmitter signalling, recent years have witnessed the emergence of Signal Transduction as an independent discipline covering all aspects of information transfer between cells irrespective of the nature and source of the signals. This book is designed for senior undergraduate/graduate-level students interested in a basic understanding of the major participants in the cellular Signal Transduction pathways. The book covers the major topics in Signal Transduction: receptors, which recognize the signals at the cell surface; G-proteins, which transduce the signals; and adenylate cyclases, guanlate cyclases, and phospholipases, which generate second messengers. Chapters also focus on ion channels, phosphodiesterases, protein kinases, phosphoprotein phosphatases and nitric oxide, which participate in the cellular response to signals; the health consequences of defects in Signal Transduction proteins; and the central role Signal Transduction plays in drug abuse. The book is suitable for an introductory course in Signal Transduction as well as for self-study and review. It is recommended for biology and medical students, as well as for interdisciplinary science majors and pharmaceutical researchers.

Volume 1 of the series "Fundamentals of Medical Cell Biology" is devoted to evolutionary biology. This is presented in two parts: in the first, the structure and dynamics of RNA, DNA, and protein are dealt with. The second part is concerned with the origins and cellular basis of life.

This three-volume set explores Problems and Solutions in Medical Physics. These invaluable study guides should be used in conjunction with other key textbooks in the field to provide additional learning opportunities. Volume one explores Diagnostic Imaging Physics and contains problems and solutions on key imaging modalities, exploring X-ray, mammography, and fluoroscopy, in addition to computed tomography, magnetic resonance imaging, and ultrasonography. Volume two explores Nuclear Medicine and contains problems and solutions on radioactivity and nuclear transformation, radionuclide production and radiopharmaceuticals, non-imaging detectors and counters, instrumentation for gamma imaging, SPECT and PET/CT, imaging techniques, radionuclide therapy, internal radiation dosimetry, and quality control and radiation protection in nuclear medicine. Volume three explores Radiotherapy and contains problems and solutions on external beam therapy equipment, photon beam physics, radiation dosimetry, treatment planning for external beam radiotherapy, and external beam commissioning and quality assurance. Each chapter provides examples, notes, and references for further reading to enhance understanding. Features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology sciences examinations

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 54, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

Ever since the discovery of the photoelectric effect, researchers have been trying to improve the efficiency of converting sunlight into electricity through photovoltaic devices. Photosynthetic organisms provide clues for harvesting sunlight and storing the energy in chemical forms. This book offers a concise overview of the fundamental concepts of photosynthesis and the emerging photovoltaic technologies, casting light on the symbiotic relation between these spheres of science. Although there are many books about the fundamentals of photosynthesis and the various aspects of the photosynthetic processes, this is the first volume to focus on the prospects of studying the photosynthetic proteins, understanding and applying their properties to design prospective solar energy conversion devices that are sustainable and efficient. All in all, the book aims to bring together the present know-how on organic photovoltaics and dye-sensitized solar cells with that of the emerging bio-photovoltaics and the underlying physics of photosynthesis to foster a more eclectic research that would converge towards a sustainable energy technology for the future. The book mainly serves as a bridge to connect biochemists, who study photosynthetic proteins, and physicists and engineers who design and develop photovoltaic devices. Scientists, engineers and students in the fields of photosynthetic research and solar energy research can use this book as a ready reference. Key selling features: Covers both methods and bio-based materials needed to build bio-based photovoltaics Focuses on both techniques and applications Summarizes the advantages and limitations of various techniques Contributors from multiple disciplines integrate the knowledge of photosynthetic proteins and the physics/engineering of photovoltaic devices. Includes adaptive designs and techniques used in other types of solar cells to for the design of protein-based PVs

An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

This book discusses the European Union's approach to governance reform in its development assistance relationships with various groups of developing countries. A group of expert authors outline the general features of the position on governance taken by the EU, which is currently the major multilateral donor of development assistance, and discuss the implementation of EU policies in a set of cases: the group of African, Caribbean and Pacific (ACP) states, the New Partnership for Africa's Development (NEPAD), Southeastern Europe, Central Asia, the Euro-Mediterranean, Latin America and fragile states. The contributions to the book argue that the EU's position on governance reform, particularly since the adoption of the European Consensus on Development in 2005, has had distinctly neoliberal overtones. The EU's governance-related strategies have been instrumental to deepening market-based reform in aid-receiving countries. Policies on state-building adopted by the EU reflect mainly the interests of and ideas embraced by the EU and its member states. To an important extent, the rhetoric accompanying EU policies does not match with the political and social dynamics inherent in governance structures on the ground in many of its aid-recipient partner countries. This book was published as a special issue of Third World Quarterly.

Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin (a 1AT) deficiency, this up-to-date reference discusses the complex pathobiological processes underlying the pathogenesis of a1AT deficiency, describes the a1AT gene and its promoter, and details specific therapies to prevent the major clinical manifestations of the disorder.

This book is dedicated to the field of conductive polymers, focusing on electrical interactions with biological systems. It addresses the use of conductive polymers as the conducting interface for electrical communications with the biological system, both in vitro and in vivo. It provides an overview on the chemistry and physics of conductive polymers, their useful characteristics as well as limitations, and technologies that apply conductive polymers for medical purposes. This groundbreaking resource addresses cytotoxicity and tissue compatibility of conductive polymers, the basics on electromagnetic fields, and commonly used experimental methods. Readers will also learn how cells are cultured in vitro with conductive polymers, and how conductive polymers and living tissues interact electrically. Throughout the contents, chapter authors emphasize the importance of conductive polymers in biomedical engineering and their potential applications in medicine.

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers:

• Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency
• The conserved features of the organization of the active site structures of enzymes
• The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions
• Interactions between the active site residues and the substrate molecules

Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

The book provides an insight into the advantages and limitations of the use of fractals in biomedical data. It begins with a brief introduction to the concept of fractals and other associated measures and describes applications for biomedical signals and images. Properties of biological data in relations to fractals and entropy, and the association with health and ageing are also covered. The book provides a detailed description of new techniques on physiological signals and images based on the fractal and chaos theory. The aim of this book is to serve as a comprehensive guide for researchers and readers interested in biomedical signal and image processing and feature extraction for disease risk analyses and rehabilitation applications. While it provides the mathematical rigor for those readers interested in such details, it also describes the topic intuitively such that it is suitable for audience who are interested in applying the methods to healthcare and clinical applications. The book is the outcome of years of research by the authors and is comprehensive and includes other reported outcomes.

This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms. Features: Focus on intramolecular actions Mechanisms of action richly illustrated Self-assessment included Comprehensive chapters on vitamins and biotechnological products Focus on intramolecular actions Mechanisms of action richly illustrated Self-assessment included Comprehensive chapters on vitamins and biotechnological products

Harry Baker and Rosalind Ridley have done an admirable job in assem bling this collection of articles that describe the methodology frequently used to study a group of CNS illnesses often referred to as the "prion diseases." Research on prions and the disorders that they cause has progressed relatively rapidly over the last decade since the discovery of the prion protein (PrP) that allowed the application of modem molecular biological and genetic tools. The power of these techniques is awesome and their use in deciphering the once mysterious prion diseases has brought a wealth of new information. Although prions are unprecedented pathogens, appearing to consist only of PrPSc molecules, the diseases that they cause are no less remarkable. The prion diseases in animals include scrapie of sheep and goats as well as "mad cow" disease or bovine spongiform encephalopathy (BSE). In the United King dom, the epidemic of BSE has heightened public awareness of this previously obscure group of diseases such that any work in the field is likely to stir up interest in the media and become a subject of public debate. It has been diffi cult for British investigators to work on prion diseases without being involved in these controversies. As such, several chapters have been included that deal with political and social issues surrounding prion diseases. The human prion diseases present an equally fascinating saga in which these CNS degenerations present as genetic, sporadic, and infectious illnesses."

Designed for clinically focused, introductory anatomy coverage, Netter's Essential Systems-Based Anatomy provides superbly illustrated core content in anatomy in a concise, easy-to-understand format. This highly visual text contains student-friendly features such as basic information and vocabulary, key systems-based concepts, and interactive practice questions for review-all highlighted by outstanding illustrations by Frank H. Netter, MD, Carlos Machado, MD and other medical artists. Focuses on the most important, clinically relevant structures and anatomic foundations that students need to learn in an integrated clinical curriculum. Organizes chapters by body system, with each chapter covering basic information and vocabulary, explanations of key concepts, clinical relevance of structures, and chapter review questions. Highlights ways that students can visualize and retain hard-to-remember concepts for exams and clinical practice. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.