This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Gold nanoparticles provide a platform for the development of new and efficient diagnostic and therapeutic tools.This book offers a general guide to the synthesis and coating of gold nanoparticles. It describes the links between optical features and geometries of gold nanoparticles and provides a readily comprehensible connection in all the chapters between the geometry of gold nanoparticles and their final applications.

Atlas of Small Animal Ultrasonography, Second Edition is a comprehensive reference for ultrasound techniques and findings in small animal practice, with more than 2000 high-quality sonograms and illustrations of normal structures and disorders. * Provides a comprehensive collection of more than 2000 high-quality images, including both normal and abnormal ultrasound features, as well as relevant complementary imaging modalities and histopathological images * Covers both common and uncommon disorders in small animal patients * Offers new chapters on practical physical concepts and artifacts and abdominal contrast sonography * Includes access to a companion website with over 140 annotated video loops of the most important pathologies covered in each section of the book

It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be.
We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.

"Fractals in Biology and Medicine, Volume 2" explores the potential of the fractal geometry in understanding how to analyse natural shapes. The volume devotes special emphasis to the complex field of human tumours.

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

The seventh volume of a multi-volume work designed for medical students with rudimentary knowledge of cellular biology. It is the key discipline for the basic medical sciences and clinical medicine to be taught in an integrated curriculum. This text features developmental biology.

Leading experts in nanobiotechnology comprehensively review the most recent advances in instrumentation and methodology, as well as their applications in genomics and proteomics. The authors provide a wide variety of techniques and methods for dealing with protein functions and structures at the nanoscale level, including nanostructured systems, nanomaterials, carbon nanotubes and nanowires, optical nanosensors, and nanoelectrodes. Among the highlights are techniques for the in vivo tracking of biochemical processes using fluorescent molecular probes and nanosensors, and the exploration of biochemical processes and submicroscopic structures of living cells at unprecedented resolutions using near-field optics. Also discussed is the development of nanocarrier methodology for the targeted delivery of drugs whose shells are conjugated with antibodies for targeting specific antigens.

This 8-volume set provides a systematic description on 8,350 active marine natural products from 3,025 various kinds of marine organisms. The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with 264 structural types are developed as well. The 7th volume mainly illustrates the molecular formula and structures of O-heterocycles and aromatics.

This fourth volume in the series, dedicated entirely to the results of the first European study of the effects of long-term confinement and isolation. The volume continues to attempt to fulfill the aim of this series, to bring the findings and accomplishments in the field of space biology and medicine to a wider group of scientists than merely the relatively small group of biologists and physiologists currently involved in space experimentation.
The contributions are not only nicely spread geographically with three chapters from the United States, two each from Russia, Europe, and Japan, they also offer a wide range of topics in the field, covering humans, animals, plants, cells, and even potential extraterrestrial beings.
As before, not only problems investigated and results obtained are reviewed, but also some of the technical aspects peculiar to this field are treated. An example in this volume is the chapter on virtual environments by Ellis, which is meant to help investigators understand the opportunities that these techniques might offer for future investigations.
In view of the limitations on flight opportunities and the constraints still inherent in orbital experimentation, it is also important to consider the information that can be obtained from studies on the ground. In addition to simulation studies like bed rest for human subjects (see the chapter by Edgerton et al. on neuromuscular adaptation), tail suspension of rats, and plants on a clinostat (see the chapter by Masuda et al.), there is the interesting possibility of using gravitropic mutants for studying the effects of weightlessness on plant growth as described by Takahashi and Suge.
Two chapters are devoted to a review of the results on rats flown on nine Cosmos biosatellite flights between 1973 and 1989: the chapter by Krasnow deals with the neuromorphological effects of micro- and hypergravity; that by Popova and Grigoriev with the metabolic effects of spaceflight. The effects of weightlessness on heart and lung function in humans are reviewed in detail by Bonde-Petersen and Linnarson.
While the study of humans, animals, and plants in spaceflight have taught us much about the effects of the space environment on living organisms, we still have a very limited understanding of the mechanisms operating in these effects. The chapter by Rijken et al. on the effects of gravity on the cellular response to epidermal growth factor demonstrates how, by a judicious use of experiments on the ground and in sounding rockets, the mechanism of a microgravity effect on cell growth could be unravelled.
The question whether there is intelligent life elsewhere in the universe has intrigued mankind for a long time. In the chapter by Coulter et al. on NASA's High Resolution Microwave Survey the project to search for the existence of such life is described. The postscript to this chapter tells how through an unfortunate decision of the U.S. Congress this project after a successful start is threatened with an untimely ending.

Shows cranial nerves and vessles in the base of brain. Also provides lateral and sagittal section views of the arteries of the brain. Illustrates lobes, limbic system, ventricles of the brain, coronal section, Circle of Willis, circulation of cerebrospinal fluid (CSF), somatotopic organization of the cerebrum and meninges of the brain. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.

This 8-volume set provides a systematic description on 8,350 active marine natural products from 3,025 various kinds of marine organisms. The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with 264 structural types are developed. The 6th volume illustrates the molecular formula and structures of aliphatic metabolites.

The collected papers in this volume cover the effects of environmental stress under a biological and energetic model. Examples are taken from fossil and living animal populations, and from outlier human populations and traditional societies. These examples indicate that stress increases energy demands and so reduces reproductive fitness. A wide range of stressful situations also are analyzed under the less stringent conditions experienced by modern human populations, when cultural factors assume importance. These emphasize the interaction between genetic, physiological, psychological and social factors in everyday life and in clinical settings.

Recent progress in brain science has been remarkable, especially with regard to advances in the area of neuroscience. Particularly in the past decade, there have been many important discoveries about signal transduction in the brain. With this background, biological research in affective disorders has become well developed in relation to neural signaling. However, this field is fairly hard to understand comprehensively, and there is relatively little integrative work with clinical psychiatry in spite of the involvement of a wide variety of scien tific disciplines. This monograph brings together up-to-date reviews from several young Japanese scientists who work in basic and clinical neuroscience. The intention is to explain in plain language the information that has evolved on signal transduction in terms of the biological abnormalities and mechanisms of anti depressants. The model shown on the cover (and on page 24) is intended to help the reader understand signal transduction in the brain and the patho physiology of affective disorders as well as the mechanisms of antidepressants.

This uniquely accessible volume challenges professionals to understand-and help correct-health disparities, both at the patient level and in their larger social contexts. Dedicated to eradicating this ongoing injustice, contributors focus on marginalized populations, the role of healthcare systems in perpetuating inequities, the need for deeper engagement and listening by professionals, and the need for advocacy within professional education and the political/policy arena. The compelling case narratives at the core of the book illustrate the interrelated biopsychosocial components of patients' health problems and the gradations of learning needed for practitioners to address them effectively. The book's tools for developing a health disparities curriculum include a selection of workshop exercises, facilitator resources, and a brief guide to writing effective case narratives. A sampling of the narratives: "Finding the Person in Patient-Centered Health Care" (race/ethnicity/culture). "The Annual Big Girl / Big Boy Exchange" (gender). "Just Give Me Narcan and Let Me Go" (poverty/addiction). "Everyone Called Him Crazy" (immigration). "Adrift in the System" (disability). "Aging out of Pediatrics" (mental illness and stigma). "Time to Leave" (LGBT) A work of profound compassion, Health Disparities will be of considerable interest to researchers and practitioners interested in public health, population health, health disparities, and related fields such as sociology, social work, and narrative medicine. Its wealth of educational features also makes it a quality training text. "I was impressed when I read Health Disparities: Weaving a New Understanding through Case Narratives. As a patient who has experienced unpleasant situations in health care, I was moved to see that it was emotional and personal for the writers. The book confirms for me that the time is now for change to take place in our health care systems. I see this book as a light that can shine bright in the darkest places of health care. The editors have assembled a powerful book that provides all health professionals with specific steps they can take towards addressing and then eventually eliminating health disparities. A few steps that I really connected with were improving critical awareness, delivering quality care, listening and empathizing with patients and families, and advocating for changes. I recommend that anyone interested in working to improve health care obtain a copy of this book-it's filled with useful information that every medical professional should know. The book reminds me of a quote by Wayne Dyer, 'When you change the way you look at things, the things you look at change.'" -Delores Collins, Founder and Executive Director, A Vision of Change Incorporated, Certified Community Health Worker. Founder of The Greater Cleveland Community Health Workers Association.

The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi?cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci?city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi?ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an?-amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals.

The presentation and interpretation of visual information is essential to almost every activity in human life and most endeavors of modern technology. This book examines the current status of what is known (and not known) about human vision, how human observers interpret visual data, and how to present such data to facilitate their interpretation and use. Written by experts who are able to cross disciplinary boundaries, the book provides an educational pathway through several models of human vision; describes how the visual response is analyzed and quantified; presents current theories of how the human visual response is interpreted; discusses the cognitive responses of human observers; and examines such applications as space exploration, manufacturing, surveillance, earth and air sciences, and medicine. The book is intended for everyone with an undergraduate-level background in science or engineering with an interest in visual science. This second edition has been brought up to date throughout and contains a new chapter on "Virtual reality and augmented reality in medicine."

Animal cells present an extreme variability in their shapes in relation to their physiological properties. For instance, fibroblastic cells are tightly attached to the extra-cellular matrix and display a flattened, spindle-shaped morphology. Neuronal cells self-organize as a network through a complex branching of dendrites and a long axonal extension. Resting peripheral blood lymphocytes are poorly adhesive and maintain a spherical, smooth shape, while macroph- ages produce many pseudopodal extensions involved in the recognition of foreign molecules. In addition to the variability of the morphology of the cells that constitute different organs, many cell types also modify dynamically their morphology in response to environmental changes, leading to differential cell motility, migration, adhesion, polarity or intercellular contacts. This wide plasticity of cell morphology is promoted and maintained by the cytoskeleton, which is composed of the three interconnected actin micro filaments, tubulin microtubules and intermediate filaments networks, all capable of assembly and disassembly. Over the past few years, the Rho family of Ras-like GTPases emerged as key proteins that mediate extracellular signalling pathways leading to the forma- tion of polymerized actin-containing structures such as ruffles, lamellipodia and filopodia. Since the discovery of the first member RhoA in 1985, 13 mem- bers have so far been characterized in human cells. Most of Rho proteins are highly conserved between species as distant as yeast, slime mold, insects and mammals, which points to their fundamental role in cellular physiology.

This volume is intended to complete the Cell Chemistry and physiology module. It is about how the traditional boundaries of cell chemistry and physiology are being erased by molecular biology. We do not think it necessary to elaborate on this theme, particularly since the body of core knowledge found in this volume brings us a stage closer to answering the question, "what makes cell biology into a new discipline?"
The first part of the volume deals with the chemistry of actin and myosin and is followed by chapters on cell motility, ATP synthesis in muscle, and contraction in smooth and skeletal muscle. Here the reader is immediately made aware of the contributions molecular biology is making to our understanding of the molecular mechanisms underlying muscle contraction. It is perhaps enough to point out that Huxley's concept of the cross-bridge cycle and generation of force can now be explained in molecular terms. Topics such as muscle fatigue and muscle disorders, as well as malignant hyperthermia are bound to arouse active learning in the student and set the stage for problem-based learning.
Most medical students look askance at thermobiology. We think this is a mistake; hence, we have included a section dealing with this subject. This brings us to the chapter on the heat shock response, which at the very outset makes clear that many stressors besides heat are known to result in heat shock gene expression. Many of the heat shock proteins occur in unstressed cells and some of them behave as chaperones. These proteins also reach high levels in a wide range of diseases including neurodegenerative disorders. Whether certain diseases are the result of mutations in the heat shock genes is not yet known. As will be appreciated, much of the work done in this field involved the use of cultured cells. Animal cells in culture are the subject of the last chapter.

This book combines orthopedists' and radiologists' perspectives to provide a comprehensive overview of the rapidly expanding use of ultrasound in orthopedic surgery. It also highlights the growing awareness of the potential of this non-invasive and portable, real-time imaging tool, which has led to its inclusion in the minimally invasive toolkit of upper limb surgeons.The book is divided into five parts - shoulder, elbow, forearm, hand and wrist and fingers. Each part focuses on a particular anatomic region or joint, carefully analyzing the sonoanatomy of its nerves, tendons and bones. For each region, experienced experts illustrate how to perform specific techniques under ultrasound control, ranging from classic procedures, like carpal tunnel release, to the treatment of less common conditions. Covering all the basic and practical aspects of this innovative, multi-disciplinary approach, as well as future perspectives, this unique book is a must-read for all orthopedists, radiologists, sports physicians and physiotherapist wanting to gain insights into this promising field.

We live in an unprecedented era of flourishing of scientific publishing. However, many professionals in the biomedical sciences find writing articles to be a daunting task. The book is meant to serve as a practical writing guide that covers the writing process from the project's inception until online distribution of the published article.The book covers the framework for constructing a scientific study into a coherent narrative that can later be easily translated into a written manuscript. The content of each article section in accordance with the IMRAD format is covered and many details for the construction of additional submission materials are provided. Characteristics of papers reporting on specific types of research are presented as well as article types other than the general full research article. The book is full of resources for additional reading and learning.There are many writing guides on the market. Most of them are general, cover a wide range of scientific writing, and are mainly aimed at students. This book is best suited for young professionals who are a few years out of school. They no longer enjoy the benefit of close mentoring by a thesis adviser or equivalent, but still lack the experience to lead writing projects on their own. Through her experience of teaching young professionals and editing their work, Dr Diskin has learned their unique set of needs and the book has been written in an attempt to address them. Dr Diskin addresses the reader in the second person, with an ever-supportive tone. Importantly, the practicalities of writing articles in today's interconnected environment are discussed throughout the book. Topics such as coordinating the writing in a multinational team, use of different types of software in the writing process and resources available online to support the writer are addressed in detail.Related Link(s)

Expert researchers who have developed and applied significant new assays describe in step-by-step detail a variety of methods for measuring a broad variety of hormones, related peptides, and synthetic steroids in various biological fluids. The hormones measured range from glucocorticoids in biological fluids, urinary steroids, aldosterone in blood, and plasma renin activity, to gut hormones in plasma, melatonin, prolactin, 6-sulfatoxymelatonin, and androgens in blood, saliva, and hair. The emphasis is on noncommercial assays so that investigators can set up novel methods suited to their special needs. Commercial assays are also described for comparative purposes. Tutorials on radioimmunoassay, gas chromatography-mass spectrometry, high-performance liquid chromatography, and PCR techniques help the reader to choose the best method for his or her purpose.

This book provides a comprehensive, state-of-the art review of intestinal polyposis syndromes. The book reviews the most up-to-date clinical, management, and genetic information regarding the continually evolving colorectal condition that manifests as a polyposis condition. It provides a reference for clinicians and researchers in understanding the complexity of intestinal polyposis and the importance of utilizing multiple modalities for the diagnosis, management and control of these conditions. It also provides an overview of what should alert a care provider to the possibility of a polyposis syndrome. Written by experts in their fields, Intestinal Polyposis Syndromes: Diagnosis and Management is a valuable resource for physicians and researchers who deal with the challenges of diagnosing and managing colorectal cancer and intestinal polyposis syndromes.