The horizons of sophisticated imaging have expanded with the use of combined positron emission tomography (PET) and computed tomography (CT). PET-CT has revolutionized medical imaging by adding anatomic localization to functional imaging, thus providing physicians with information that is vital for the accurate diagnosis and treatment of pathologies. Since the integration of PET and CT several years ago, PET/CT procedures are now routine at leading medical centers throughout the world. This has increased the importance of nuclear medicine physicians acquiring a broad knowledge in sectional anatomy for image interpretation. The Atlas of Sectional Radiological Anatomy for PET/CT is a user-friendly guide presenting high-resolution, full-color images of anatomical detail and focuses solely on normal FDG distribution throughout the head & neck, thorax, abdomen, and pelvis, the primary sites for cancer detection and treatment through PET/CT.

Measurement of solid tumor response to treatment relies mainly on imaging. WHO tumor response criteria and, more recently, RECIST (response evaluation criteria in solid tumors) have provided means to objectively measure tumor response in clinical trials with imaging. These guidelines have been rapidly adopted in clinical practice to monitor patient treatment and for therapy planning. However, relying only on anatomical information is not always sufficient when evaluating new drugs that will reduce a tumor's functionality while preserving its size. Finding more reliable and reproducible measures of tumor response is one of the most important and difficult challenges facing modern radiology as it requires an entirely new approach to imaging. The aim of this book is to address the assessment of response to treatment by adopting a multidisciplinary perspective, just as occurs in real life in a comprehensive cancer center. Oncologists and imaging experts consider two cancer models, locally advanced disease and metastatic disease, jointly exploring both conventional and advanced means of measuring response to standard treatment protocols and new targeted therapies.

"Organic Trace Analysis" presents the basics of trace analysis, from sample preparation to the measurement: Students are introduced to statistical evaluation, quality control technologies, sampling and preparation of organic traces, as well as to enrichment and separation of samples. Spectroscopic techniques as chromatography, capillary electrophoresis, mass spectrometry, and receptor-based bioanalysis are presented in detail.

An einem der Geschichte der Krebsforschung entnommenen Fall wird untersucht, wie sich Wissensentwicklung zum Wandel sozialer Formen des Forscherverkehrs verhalt und welche Rolle dabei wissenschaftliche Kontroversen spielen: Sie zersetzen nicht allein uberkommene Paradigmen, sondern uberdies die gegebenen sozialen Gliederungen und schaffen so Bedingungen fur den Wandel derselben (Disziplinen, Institutionen). Dieser Ansatz erlaubt die Abwehr eines Konzeptes, wonach die Schliessung einer Kontroverse auf die Favorisierung einer der strittigen Positionen hinauslauft. Ein solcher Prozess wird von Forschern eingeleitet, die das Verhaltnis gegeneinander vertretener Konzepte zu harmonisieren trachten, ohne dabei auf eine transdisziplinare bzw. theoretisch schlussige Vermittlungsbasis zu verweisen.

Blood science has become a cornerstone of multiple disciplines, including clinical chemistry, disease diagnosis, and therapeutic monitoring. Over the past decade, we have witnessed the advent of increasingly powerful proteomics technologies that allow greater fundamental insights into the blood proteome. These technological improvements have, in part, fuelled the quest for the discovery of novel blood-based biomarkers of disease. Serum/Plasma Proteomics: Methods and Protocols is a comprehensive resource of protocols for areas, pre-analytical through to analytical, of plasma and serum proteomics. Divided into five convenient sections, this detailed volume covers fractionation strategies for in-depth blood proteome analysis, defined procedures for blood collection, handling and storage, detailed protocols for performing both antibody-based and non-antibody based quantitative assays, proteome analysis of blood cell compartments, circulating nanomebraneous vesicles and blood-related fluids, and finally data management, statistical design, and bioinformatic challenges. This book, contributed to by leading experts in the field, provides a valuable foundation for the development and application of blood-based proteomics. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Serum/Plasma Proteomics: Methods and Protocols, with its well-honed methodologies, seeks to serve both professionals and investigators new to the field in an effort to further our knowledge of this fundamental science.