This indispensable guide offers detailed coverage of the regulations, requirements, and techniques for the validation of processes and systems used in regulated international industries - addressing all significant requirements for pharmaceutical, medical device, and biologic companies as well as environmental laboratories. Elucidating up-to-the-minute industry changes and international concerns, Validation Compliance Annual 1995 examines Good Manufacturing Practices (GMPs), Good Clinical Practices (GCPs), Good Laboratory Practices (GLPs), and Good Automated laboratory Practices (GALPs)... provides unabridged texts of U.S. and European Union regulatory requirements as well as summaries of the validation requirements of other nations... furnishes complete guidelines and tools for system validation... supplies an in-depth look at problems related to inadequate system validation, including actual regulatory citations for noncompliance... explains the rationale behind regulatory compliance policies and inspectional practices... assesses the future of regulatory and industry trends... and more. Containing key bibliographic citations and a thorough glossary of validation terms, Validation Compliance Annual 1995 is an incomparable day-to-day workbook for analytical, pharmaceutical, food, and environmental chemists; instrumentation specialists; industrial, bio-process, chemical, and pharmaceutical engineers; quality and reliability managers and directors; laboratory managers and technicians; computer scientists; and upper-level undergraduate and graduate students in these disciplines.

This volume provides information on how to select and screen plants for their medicinal properties. It describes phytopharmacological techniques for extracting and qualitatively and quantitatively analyzing a plant's phytochemicals. After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc. Compound identification and purification techniques include, among others, TLC and column chromatography, as well as molecular docking with specific proteins.

This second edition volume expands on the previous edition with new and updated chapters on the latest developments in the study of yeast within the biotechnology field. The chapters in this book cover topics such as transformation protocols for genetic engineering of Saccaromyces cerevisiae and Komagataella spp.; an overview of selection markers, promoters, and strains used for metabolic engineering of S. cerevisiae, P. pastoris, and Z. bailii; the use of yeast in CRISPR/Cas9 technology; tools to study metabolic pathway in Yarrowia lypolitica; and a discussion on the "universal expression system" that is applied in a broad spectrum of fungal species. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Yeast Metabolic Engineering: Methods and Protocols, Second Edition is a valuable resource for researchers and scientists interested in learning more about this important and developing field.

This book is intended as an introductory text. It starts at the very fundamentals of the interaction of light and matter and progresses through the laws of light absorption, instrumentation and standards to the newer chemometric techniques. Other chapters cover colour, structural aspects of UV spectroscopy, detection in high performace liquid chromatography and flourescence.

Advanced fiber materials have been developed for various superior applications because of their higher mechanical flexibility, high-temperature resistance, and outstanding chemical stability. This book presents an overview of the current development of advanced fiber materials, fabrication methods, and applications. Applications covered include pollution control, environment, energy, information storage technology, optical and photonic, photocatalysis, textile, drug delivery, tumor therapy, corrosion protection applications, and a state of art of advanced fiber materials.

Electrochemical and Analytical Techniques for Sustainable Corrosion Monitoring presents established research and technology for corrosion monitoring and measurements. Corrosion reduction can be controlled via various ways, including process control, cathodic protection, metal impurity reduction, application of surface treatment methods, and incorporation of appropriate alloys. This is the first book that collectively describes corrosion inhibition measurements using chemical, electrochemical, and analytical methods. The book presents state-of-the art techniques for corrosion monitoring by providing detailed studies and testing methods. It also covers the most advanced, industry-oriented challenges for sustainable corrosion monitoring and measurements. The book is a valuable resource for scholars in academia, materials science and applied engineering and chemistry students, and corrosion engineers.

Successful Management of the Analytical Laboratory provides a comprehensive discussion of the problems that face analytical laboratory managers and presents proven techniques for improving the operation and performance of analytical labs. A wide range of topics are covered, including functions of various laboratory types (including a discussion of legal proceedings that involve defending laboratory data), staffing and organization, motivation, management and development of personnel, personal relations and communication, sample handling, workload optimization, equipment selection and justification, budgeting and cost control (including methods for calculating the dollar return on investments in capital equipment), and information management systems.
The book emphasizes measures that managers can take to ensure quality performance in both the laboratory and its personnel while maintaining the overall cost effectiveness of the operation. The author uses case histories from his experience to illustrate the application of the management principles presented in this excellent book for new and experienced lab managers alike.

This book consists of a series of 82 precise, easy-to-read articles by internationally renowned scientists and emphasizes the practical approach to HPLC with minimal theory, although the underlying principles for peptide and protein separations are clearly expressed. All of the major modes of microbore, ultrafast and analytical HPLC are discussed, including size-exclusion, ion-exchange, reversed-phase, hydrophobic interaction, and affinity and immunoaffinity chromatography. A section on preparative HPLC, including displacement techniques, is also presented. Problem-solving approaches to the separation of various classes of biologically active peptides and proteins are thoroughly explored, while the importance of peptide standards for monitoring column performance and for optimizing separation conditions is emphasized. Several articles focus on the choice of the correct detection method (electrochemical, UV, fluorescence), as well as the need for a proper knowledge of approaches to column and instrument maintenance and trouble-shooting. A section on predictive approaches deals with both computer simulation of peptide separations and peptide structure. The book also includes complementary techniques to HPLC, as well as other useful applications of HPLC. It enables both novice and experienced chromatographers to realize the full potential of this extremely powerful technique, in the process making an important contribution to scientific literature.

This book gives a comprehensive overview of recent advancements in both theory and practical implementation of plasmonic probes. Encompassing multiple disciplines, the field of plasmonics provides a versatile and flexible platform for nanoscale sensing and imaging. Despite being a relatively young field, plasmonic probes have come a long way, with applications in chemical, biological, civil, and architectural fields as well as enabling many analytical schemes such as immunoassay, biomarkers, environmental indexing, and water quality sensing, to name but a few. The objective of the book is to present in-depth analysis of the theory and applications of novel probes based on plasmonics, with a broad selection of specially-invited chapters on the development, fabrication, functionalization, and implementation of plasmonic probes as well as their integration with current technologies and future outlook. This book is designed to cater to the needs of novice, seasoned researchers and practitioners in academia and industry, as well as medical and environmental fields.

This book presents the conference proceedings of the F-EIR Conference 2021, Environment Concerns and its Remediation held in Chandigarh, India, October 18-22, 2021. The purpose of the conference and the volume is to present new ideas across a range of disciplines in environmental science, with a focus on theoretical and practical approaches to clean production aimed at preventing the production of waste, while increasing efficiencies in the uses of energy, water, and renewable resources. With contributions from leading experts equipped with state-of-the-art information and technology, the book covers topics of sustainability and resilience, chemical and environmental engineering, materials science, biotechnology, health-related microorganisms, and green technologies. The book will be of interest to scientists, engineering professionals, architects, environmental scientists, academicians, economists, and students engaged in these disciplines.

This book provides a comprehensive presentation of the most frequently used high resolution manufacturing techniques available, as well as the polymeric materials used for each of the techniques. Divided into two parts covering the technologies and materials used and the impact on different research fields and case studies, High Resolution Manufacturing from 2D to 3D/4D Printing: Applications in Engineering and Medicine addresses issues like throughput improvement by volumetric 3D printing and presenting novel applications and case studies. In addition, this book also covers the latest breakthrough developments and innovations to help readers understand the future applications of this technology across various disciplines, including biomedicine, electronics, energy, and photonics.

"WHAT DOES NOT NEED TO BE BIG, WILL BE SMALL," a word by an engineer at a recent conference on chips technology. This sentence is particularly true for chemistry. Microfabrication technology emerged from microelectronics into areas like mechanics and now chemistry and biology. The engineering of micron and submicron sized features on the surface of silicon, glass and polymers opens a whole new world. Micromotors smaller than human hair have been fabricated and they work fine. It is the declared goal of the authors to bring these different worlds together in this volume. Authors have been carefully chosen to guarantee for the quality of the contents. An engineer, a chemist or a biologist will find new impulses from the various chapters in this book.

Enzymes are bio-catalysts which effect transformation of substrates to products with high specificity. The usage of enzymes in domestic and industrial applications is well known and has been well documented since the early history of civilization. With the advances in understanding of enzymology, usage of enzymes in industrial and biotechnological pro cesses and molecular medicine has proliferated. One of the key factors in the widespread application of enzymes in modern technologies is the development of enzyme immobilization tech niques, which overcome certain practical, functional and economic con straints. Many natural enzymes can be stabilized by immobilization on solid matrices, with most of the activity retained, for a variety of applica tions. An important application of immobilized enzymes is in liquid chromatography. In the last decade, post-column enzyme detection has become established as an important discipline in liquid chromatography. The new detection approach offers more sensitive and specific ways for measuring major classes of biomolecules. Reactors are fabricated by packing the immobilized enzymes into small columns, which can be placed immediately after an HPLC column."

Chemical vapor sensing arrays have grown in popularity over the past two decades, finding applications for tasks such as process control, environmental monitoring, and medical diagnosis. This is the first in-depth analysis of the process of choosing materials and components for these "electronic noses", with special emphasis on computational methods. For a view of component selection with an experimental perspective, readers may refer to the complementary volume of Integrated Microanalytical Systems entitled "Combinatorial Methodologies for Sensor Materials."

This book presents a variety of climate change impact and mitigation strategies for different environments in India. These include fractional snow cover change in the Himalayan region, and the impact of frequent cyclonic storms on land use and land cover changes along coastal areas. The book explores watershed, surface water, and hydrologic conditions for urban storm water drainage, as well as trend analysis of precipitation, and a statistical approach to detect rainfall trends. The book starts with a critical review of climate change diplomacy, adaptation and mitigation strategies in South Asian countries. It also covers the role of natural gas in energy security. There are chapters pertaining to farmer's perception on the impact of climate change, as well discussion on land use change and ecological implications. Many geographical areas are covered including; the Mahananda River Basin, Pindar Basin, Kumaun Himalaya, the Upper Tapi River Basin, Southern Kerala Districts, Uttar Pradesh, Karnataka State, Telangana State, Tamil Nadu State, to name a few.

The objective of the Springer Handbook of Enzymes is to provide, in concise form, data on enzymes that have been sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. Each volume comprises one enzyme class, sometimes the enzyme classes have to be divided into several volumes. Considerable progress has been made in enzymology since the publication of the first edition (published as "Enzyme Handbook"): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: "application" and "engineering" (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of approx. 25 volumes. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.  

When developing new food products, it is important to understand the major mechanisms of food macromolecule interactions. The first edition of this book provided a useful scientific and theoretical base describing the reasons for polymer action. The second edition updates the substantial progress that has occurred during the last ten years in many aspects of understanding, measuring, and utilizing functional macromolecules. The shift to analyzing mixtures rather than single polymers is assessed and the relevant interactions that are known to take place between the large molecules are examined. A new chapter on high pressure processing is included to show the importance of new methodology to texturize proteins. The book is an essential reference for food scientists who need to understand the fundamental principles that underlie functional behavior of interacting food macromolecules.

This volume offers an overview of the occurrence and distribution of personal care products in continental and marine waters, presents analytical methods and degradation technologies and discusses their impact on human health. Experts from different disciplines highlight major issues for each family of compounds related to their occurrence in the water column as well as in solid and biota samples, methodological strategies for their analysis, non-conventional degradation technologies, (eco)toxicity data and their human and environmental risk assessment. The book also includes a general introduction to personal care products, covering their properties, use, behaviour and regulatory framework, and a final chapter identifying knowledge gaps and future research trends. It will appeal to experts from various fields of research, including analytical and environmental chemistry, toxicology and environmental engineering.

This book presents Internet of Things (IoT) solutions monitoring and assessing a variety of applications areas for indoor air quality (IAQ). This book synthesizes recent developments, presents case studies, and discusses new methods in the area of air quality monitoring, all the while addressing public health concerns. The authors discuss the issues and solutions, including IoT systems that can provide a continuous flow of data retrieved from cost-effective sensors that can be used in multiple applications.The authors present the leading IoT technologies, applications, algorithms, systems, and future scope in this multi-disciplinary domain.

The book explains the principles and fundamentals of Green Analytical Chemistry (GAC) and highlights the current developments and future potential of the analytical green chemistry-oriented applications of various solutions. The book consists of sixteen chapters, including the history and milestones of GAC; issues related to teaching of green analytical chemistry and greening the university laboratories; evaluation of impact of analytical activities on the environmental and human health, direct techniques of detection, identification and determination of trace constituents; new achievements in the field of extraction of trace analytes from samples characterized by complex composition of the matrix; "green" nature of the derivatization process in analytical chemistry; passive techniques of sampling of analytes; green sorption materials used in analytical procedures; new types of solvents in the field of analytical chemistry. In addition green chromatography and related techniques, fast tests for assessment of the wide spectrum of pollutants in the different types of the medium, remote monitoring of environmental pollutants, qualitative and comparative evaluation, quantitative assessment, and future trends and perspectives are discussed. This book appeals to a wide readership of the academic and industrial researchers. In addition, it can be used in the classroom for undergraduate and graduate Ph.D. students focusing on elaboration of new analytical procedures for organic and inorganic compounds determination in different kinds of samples characterized by complex matrices composition.Jacek Namiesnik was a Professor at the Department of Analytical Chemistry, Gdansk University of Technology, Poland. Justyna Plotka-Wasylka is a teacher and researcher at the same department.