A major strength of American Chemical Society (ACS) is the large number of volunteers who help to grow and sustain the organization, from local sections to technical divisions, from regional to national meetings, from task forces to national committees, and from conducting research to writing and reviewing manuscripts for journals. Some of them spend literally thousands of hours on behalf of ACS and the global chemistry enterprise, helping students or fellow scientists, organizing meetings and symposia, and reaching out to the local communities. One of the people who excelled in these efforts was the late Prof. Ernest L. Eliel. For many years he taught at the University of Notre Dame and the University of North Carolina and was an acknowledged leader in organic stereochemistry and conformational analysis. He was also a leader at ACS, serving as ACS President in 1992 and Chair of ACS Board of Directors in 1987-89. Unfortunately Prof. Eliel died in 2008, but the ACS held a symposium in 2016 honoring his work. This book features two volumes highlighting stereochemistry and global connectivity, which represent two of the key legacies of Prof. Eliel. Because stereochemistry is a fundamental chemistry concept, ongoing research is carried out in different subfields of chemistry (such as organic, medicinal, carbohydrates, polymers), using various analytical techniques (such as NMR, X-ray crystallography, and circular dichroism). The two volumes of this book contain many research papers that represent cutting-edge research in all the above areas. Because chemistry is now a world-wide enterprise, global connectivity is important to chemistry practitioners, and the chapters on international activities should be of great interest as well.

This book is meant to be a companion volume for the ACS Symposium Series Book entitled Nuts and Bolts of Chemical Education Research. In the Nuts and Bolts book (edited by Diane M. Bunce and Renee Cole), readers were presented with information on how to conduct quality chemical education research. In the Myth book, exemplars of chemical education research are featured. In the cases where the chapter in the book is describing research that has already been published (typically in the Journal of Chemical Education), additional information is provided either in terms of research questions investigated that were not reported in the published article or background information on decisions made in the research that helped the investigation. The main focus of this type of discussion is to engage the reader in the reality of doing chemical education research including a discussion of the authors' motivation. It is expected that these two books could be used as textbooks for graduate chemical education courses showing how to do chemical education research and then providing examples of quality research.

In the past, the stability of milk and milk products was the primary consideration, but this is no longer the principal objective due to the evolution of modern sanitary practices as well as pasteurization. Today, the manufacture of dairy products of consistently good flavor and texture is crucial. In previous flavor studies, researchers identified hundreds of volatile compounds, with little or no attention paid to their sensory contribution to overall flavor of dairy products. The availability of powerful chromatographic separation techniques like high resolution gas chromatography in combination with mass spectrometry and olfactory detection ports have revolutionized the work on characterization of dairy flavor. This along with recent developments in sensory methods and our increased knowledge about the genomics of diary culture organisms have allowed great advancements in our understanding of dairy flavor chemistry. Flavor of Dairy Products covers the evolution of dairy flavor research and presents updated information in the areas of instrumental analysis, biochemistry, processing and shelf-life issues related to the flavor of dairy products.

This book focuses on broadly defined areas of chemical information science- with special emphasis on chemical informatics- and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jurgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.

This book addresses one of the most challenging problems that plagues the environmental field today-subsurface contamination. The past three decades have ushered in various methods for removal of organic and inorganic contaminants from the subsurface to varying degrees of effectiveness. Because of the site-to-site variability in the nature of contamination characteristics, the pattern of waste disposal and accidental releases, the site characteristics and thus contaminant behavior, and hydrologic conditions, predicting the effectiveness of one treatment method over another is a daunting task. Field demonstration of innovative technologies is a key step in their development, however, only after successful scale-up from laboratory testing. This book features chapters written by researchers who have linked laboratory- and field-scales in efforts to find creative, cost-effective methods for prediction of successful remediation of contaminated soil and ground water. State-of-the-art technologies using physicochemical removal methods and biological methods are discussed in the context of not only their effectiveness in remediating organic and inorganic wastes from various subsurface environments but also in terms of useful flask-scale methods for measuring and predicting their field-scale effectiveness. Chapters address sorption and hydrolysis of pesticides by organoclays, use of Fentons agents to destroy chlorinated solvents removed from the subsurface by granulated activated carbon, methanol flushing as a means of removing toxaphene from soils, natural attenuation as a method for effectiveness of remediation metals and biodegrading acid-mine drainage constituents, and biodegradation ofradiologically contaminated soils. Also addressed in this book are current and future methods of assessing microbiological activity potential and diversity and of modeling biodegradation, contaminant flux, and gaseous transport in the subsurface.

We are becoming increasingly aware of the overwhelming pollution of our limited water resources on this planet. And while many contaminants originate from Mother Earth, most water pollution comes as a direct result of anthropogenic activities. This problem has become so immense that it threatens the future of all humanity. If effective measures to reduce and/or remediate water pollution and its sources are not found, it is estimated by UN that 2.7 billion people will face water shortage by 2025 as opposed to 1.2 billion people who do not have access to clean drinking water now. Therefore, development of novel green technologies to address this major problem represents a priority of the highest importance. This book discusses green chemistry and other novel solutions to the water pollution problems which includes some interesting applications of nanoparticles. Novel Solutions to Water Pollution is a useful and informative text for those engaged in issues of water quality and water pollution remediation at operational, administrative, academic, or regulatory levels.

Dalton's theory of the atom is generally considered to be what made the atom a scientifically fruitful concept in chemistry. To be sure, by Dalton's time the atom had already had a two-millenium history as a philosophical idea, and corpuscular thought had long been viable in natural philosophy (that is, in what we would today call physics).
Atoms in Chemistry will examine episodes in the evolution of the concept of the atom, particularly in chemistry, from Dalton's day to our own. It begins with an overview of scientific atomic theories from the 17th through 20th centuries that analyzes corpuscular theories of matter proposed or entertained by natural philosophers in the 17th century. Chapters will focus on philosophical and religious conceptions of matter, 19th-century organic structural theories, the debate surrounding the truth of the atomic-molecular theory, and physical evidence accumulated in the late 19th and early 20th centuries that suggested that atoms were actually real, even if they were not exactly as Dalton envisioned them. The final chapter of this book takes the reader beyond the atom itself to some of the places associated with the history of scientific atomism. As a whole, this volume will serve as a passport to important episodes from the more than 200-year history of atoms in chemistry.

The American Chemical Society (ACS) Committee on Analytical Reagents sets the specifications for most chemicals used in analytical testing. Currently, the ACS is the only organization in the world that sets requirements and develops validated methods for determining the purity of reagent chemicals. These specifications have also become the de facto standards for chemicals used in many high-purity applications. Publications and organizations that set specifications or promulgate analytical testing methods-such as the United States Pharmacopeia and the U.S. Environmental Protection Agency-specify that ACS reagent-grade purity be used in their test procedures. The Eleventh Edition incorporates the "supplements" accumulated over the past eight years, removes some obsolete test methods, improves instructions for many existing ones, and also introduces some new methods. Overall, the safety, accuracy, or ease of use in specifications for about 70 of the 430 listed reagents has been improved, and seven new reagents have been added.

Consumers, regulators, and the food industry increasingly require that foods comply not only with label descriptions of food content, but also with information regarding the food's origin. For example, the wine industry has a long history of labeling wines based on varietal, regional, or age (vintage)-related properties. However, regulatory agencies are now beginning to require methods to confirm this label information. Food retailers are also facing voluntary or mandatory labeling requirements that will indicate regional or country-of-origin, species and/or varietal information. As a result, development of reliable analytical methods to confirm the authenticity of the label information is needed. This book presents the latest research on food and wine authentication. The chapters are authored by leading international scientists whose research focuses on the development and application of analytical methodologies used for the authentication of food and beverages.

Nanoscale Materials in Chemistry describes research on the development of catalysts and adsorbents based on nanoscale materials. It includes new fundamental research and applications, beginning with a review of research on the development of nanoscale metal oxides that have environmental applications. Information on product development is described for selected products that have been developed and commercialized.
This book is for scientists and engineers who are engaged in research, development, and commercialization of nanoscale materials for environmental applications. Those interested in the pathway from idea to product will find this book valuable to them. Those interested in sustainable indoor environments will find new information on in room devices that may be able to reduce energy use in buildings. Toxicology and product safety are included as well.

This book is targeted for chemists and environmental scientists and engineers who are engaged in understanding the chemistry of high-valent iron (Ferrate) and in applications of chemical oxidants to treat contaminants in water, wastewater, and industrial effluents. This book will be of interest to biochemical engineers and microbiologists who want to understand Ferrate's disinfection performance. Additionally, the book will be of tremendous interest to graduate students who are performing research on the understanding of the mechanism of higher oxidation states of iron and in developing innovative drinking water and wastewater treatment technologies.
This book addresses synthesis and properties of Ferrate(VI), which is an environmentally friendly chemical for oxidation, coagulation, and disinfection for the multipurpose treatment of water and wastewater. It provides information on using different approaches to synthesize ferrate(VI). New processes to synthesize ferrate(VI) are detailed. Properties and generations of high oxidation states of iron including ferrate(IV) and ferrate(V) are discussed. Interestingly, possible formations of iron in unusual oxidation states, +7 and +8 are also discussed. The potential use of ferrate(VI) in high energy density rechargeable batteries is thoroughly reviewed. Chapters of the book demonstrate development of new technology for removing emerging pollutants without forming toxic side reactions or by-products. Examples include endocrine disruptors (EDs) and pharmaceuticals, which are of a great concern because of their possible toxic effects on humans and the ecology of the environment. Ferrate(VI) is an emerging water-treatment disinfectant, whichcan address the concerns raised by the currently used oxidants and disinfectants. Interestingly, ferrate(VI) does not react with the bromide ion; carcinogenic bromate ion would thus not be produced in the treatment of bromide-containing water. Ferrate(VI) can inactivate chlorine resistant bacteria. This book also provides information on the means to oxidize highly resistant organics and microorganisms in order to design appropriate remediation and water treatment technology which is cleaner and greener.

In this stimulating work, Graham Richards provides general readers and students with an authoritative introduction to the central problems currently faced by chemistry. In clear, down-to-earth language he explains how atoms join to form molecules, and explores the major challenges preoccupying chemists, including the synthesis of new substances such as drugs, plastics, detergents and dyes. The book also examines the spectacular advances that have been made in the chemical understanding of genetics and the mechanisms of living organisms-- a necessary prelude to genetic engineering--and considers the various ethical and social problems spawned by the new chemistry. Richards is a widely published author of many books and articles on chemistry.

This book presents the SPH method (Smoothed-Particle Hydrodynamics) for fluid modelling from a theoretical and applied viewpoint. It comprises two parts that refer to each other. The first one, dealing with the fundamentals of Hydraulics, is based on the elementary principles of Lagrangian and Hamiltonian Mechanics. The specific laws governing a system of macroscopic particles are built, before large systems involving dissipative processes are explained. The continua are discussed, and a fairly exhaustive account of turbulence is given. The second part discloses the bases of the SPH Lagrangian numerical method from the continuous equations, as well as from discrete variational principles, setting out the method's specific properties of conservativity and invariance. Various numerical schemes are compared, permanently referring to the physics as dealt with in the first part. Applications to schematic instances are discussed, and, ultimately, practical applications to the dimensioning of coastal and fluvial structures are considered.
Despite the rapid growth in the SPH field, this book is the first to present the method in a comprehensive way for fluids. It should serve as a rigorous introduction to SPH and a reference for fundamental mathematical fluid dynamics. This book is intended for scientists, doctoral students, teachers, and engineers, who want to enjoy a rather unified approach to the theoretical bases of Hydraulics or who want to improve their skills using the SPH method. It will inspire the reader with a feeling of unity, answering many questions without any detrimental formalism.

The chapters in this monograph are contributions from the Advances in Quantum Monte Carlo symposium held at Pacifichem 2010, International Chemical Congress of Pacific Basin Societies. The symposium was dedicated to celebrate the career of James B. Anderson, a notable researcher in the field. Quantum Monte Carlo provides an ab initio solution to the Schroedinger equation by performing a random walk through configuration space in imaginary time. Benchmark calculations suggest that its most commonly-used variant, "fixed-node" diffusion Monte Carlo, estimates energies with an accuracy comparable to that of high-level coupled-cluster calculations. These two methods, each having advantages and disadvantages, are complementary "gold-standards" of quantum chemistry. There are challenges facing researchers in the field, several of which are addressed in the chapters in this monograph. These include improving the accuracy and precision of quantum Monte Carlo calculations; understanding the exchange nodes and utilizing the simulated electron distribution; extending the method to large and/or experimentally-challenging systems; and developing hybrid molecular mechanics/dynamics and Monte Carlo algorithms.

Structural crystallographic studies can determine not only the full stereochemistry of chemical species but also their details of arrangement in the crystal. Such geometrical data provide an essential basis for the interpretation of chemical, physical, and biological properties of chemical species. This volume contains key papers presented at the seventh symposium on organic crystal chemistry at Poznan in Poland. Among the themes discussed were factors influencing molecular conformation and polymorphism, chemical and biological activity, intermolecular interactions, crystal chemistry of polymers and molecular modelling.

Inspired by the opportunities and challenges presented by rapid advances in the fields of retrieval of chemical and other scientific information, several speakers presented at a symposium, The History of the Future of Chemical Information, on Aug. 20, 2012, at the 244th Meeting of the American Chemical Society in Philadelphia, PA. Storage and retrieval is of undeniable value to the conduct of chemical research. The participants believe that past practices in this field have not only contributed to the increasingly rapid evolution of the field but continue to do so, hence the somewhat unusual title. Even with archival access to several of the presentations, a number of the presenters felt that broader access to this information is of value. Thus, the presenters decided to create an ACS Symposium book based on the topic, with the conviction that it would be valuable to chemists of all disciplines. The past is a moving target depending on the vagaries of technology, economics, politics and how researchers and professionals choose to build on it. The aim of The History of the Future of Chemical Information is to critically examine trajectories in chemistry, information and communication as determined by the authors in the light of current and possible future practices of the chemical information profession. Along with some additional areas primarily related to present and future directions, this collection contains most of the topics covered in the meeting symposium. Most of the original authors agreed to write chapters for this book. Much of the historical and even current material is scattered throughout the literature so the authors strived to gather this information into a discrete source. Faced with the rapid evolution of such aspects as mobile access to information, cloud computing, and public resource production, this book will be not only of interest but provide valuable insight to this rapidly evolving field, both to practitioners within the field of chemical information and chemists everywhere whose need for current and accurate information on chemistry and related fields is increasingly important.

Low-Energy Nuclear Reactions and New Energy is a summary of selected experimental and theoretical research performed over the last 19 years that gives profound and unambiguous evidence for low energy nuclear reaction (LENR), historically known as cold fusion.
In 1989, the subject was announced with great fanfare, to the chagrin of many people in the science community. However, the significant claim of its discoverers, Martin Fleischmann and Stanley Pons, excess heat without harmful neutron emissions or strong gamma radiation, involving electrochemical cells using heavy water and palladium, has held strong.
In recent years, LENR, within the field of condensed matter nuclear science, has begun to attract widespread attention and is regarded as a potential alternative and renewable energy source to confront climate change and energy scarcity. The aim of the research is to collect experimental findings for LENR in order to present reasonable explanations and a conclusive theoretical and practical working model.
The goal of the field is directed toward the fabrication of LENR devices with unique commercial potential demonstrating an alternative energy source that does not produce greenhouse gases, long-lived radiation or strong prompt radiation. The idea of LENR has led to endless discussions about the kinetic impossibility of intense nuclear reactions with high coulomb barrier potential. However, recent theoretical work may soon shed light on this mystery.
Understanding this process is one of the most challenging and perhaps important issues in the scientific world. This book includes previously unpublished studies, new and controversial theories to approach LENR with access to new sources and experimental results. The book offers insight into this controversial subject and will help readers re-evaluate their perspective on LENR as a possible alternative energy source.

Students taught with inquiry-based methods have been shown to make significant progress in their ability to formulate hypotheses, make proper assumptions, design and execute investigations, understand variables, record data, and synthesize new knowledge. are taught with it. This text presents a series of experiments that are intended to serve as the solid basis for a first-year chemistry or physical sciences course, using an inquiry based approach. Each provides: 1)instructions for an experiment; 2) in-depth teachers notes and 3) a sample lab report.

Chemometrics and Chemoinformatics gives chemists and other scientists an introduction to the field of chemometrics and chemoinformatics. Chemometrics is an approach to analytical chemistry based on the idea of indirect observation. Measurements related to the chemical composition of a substance are taken, and the value of a property of interest is inferred from them through some mathematical relation. Basically, chemometrics is a process. Measurements are made, data is collected, and information is obtained to periodically assess and acquire knowledge. This, in turn, has led to a new approach for solving scientific problems: (1) measure a phenomenon or process using chemical instrumentation that generates data inexpensively, (2) analyze the multivariate data, (3) iterate if necessary, (4) create and test the model, and (5) develop fundamental multivariate understanding of the process. Chemoinformatics is a subfield of chemometrics, which encompasses the analysis, visualization, and use of chemical structural information as a surrogate variable for other data or information. The boundaries of chemoinformatics have not yet been defined. Only recently has this term been coined. Chemoinformatics takes advantage of techniques from many disciplines such as molecular modeling, chemical information, and computational chemistry. The reason for the interest in chemoinformatics is the development of experimental techniques such as combinatorial chemistry and high-throughput screening, which require a chemist to analyze unprecedented volumes of data. Access to appropriate algorithms is crucial if such experimental techniques are to be effectively exploited for discovery. Many chemists want to use chemoinformatic methods in their work but lack the knowledge required to decide which techniques are the most appropriate.

Tools of Chemistry Education Research meets the current need for information on more in-depth resources for those interested in doing chemistry education research. Renowned chemists Diane M. Bunce and Renee S. Cole present this volume as a continuation of the dialogue started in their previous work, Nuts and Bolts of Chemical Education Research. With both volumes, new and experienced researchers will now have a place to start as they consider new research projects in chemistry education. Tools of Chemistry Education Research brings together a group of talented researchers to share their insights and expertise with the broader community. The volume features the contributions of both early career and more established chemistry education researchers, so as to promote the growth and expansion of chemistry education. Drawing on the expertise and insights of junior faculty and more experienced researchers, each author offers unique insights that promise to benefit other practitioners in chemistry education research.

Since their discovery, disinfection by-products (DBPs) have become one of the major driving forces in drinking water regulations, research and water utility operations throughout the world. The list of DBPs that can occur in treated drinking waters has grown from a few trihalomethanes to a long list of halogenated and non-halogenated organic or inorganic compounds. This list is expected to continue to grow as the analytical techniques are improved, as more information on their toxicity is developed, and as more occurrence studies are conducted. This book documents the latest DBP research findings, including emerging issues and state-of-the-art studies. Specifically, papers on the occurrence, formation, control, and health effects of emerging (unregulated) halogenated (e.g., brominated) and nonhalogenated (e.g., nitrosamines) DBPs (e.g., emerging nitrogenous vs. regulated carbonaceous DBPs) are presented. In addition to the characterization and reactivity of natural organic matter to form DBPs, new studies on algal organic matter and treated wastewater as sources of DBPs and their precursors are discussed.

Following Ionic Liquids: Industrial Applications to Green Chemistry, SS #818, by the same editors, this book focuses on exciting new developments in ionic liquids.

Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

The world-wide sales of polysiloxanes or silicones at the beginning of this new millennium is approximately $10 billion per year. Commercial products range from those entirely composed of silicone to products where the silicone is a low level but key component. This symposium covered the recent academic and technological developments behind silicones and silicone-modified materials and the sessions were well attended of wide interest to both the academic and industrial communities. The papers from our two highly successful symposia in this important area were published in the books Silicones and Silicone-Modified Materials, (Eds. S. J. Clarson, J. J. Fitzgerald, M. J. Owen and S. D. Smith), ACS Symposium Series Vol. 729 / Oxford University Press, 2000, ISBN 0-8412-3613-5 and Synthesis and Properties of Silicones and Silicone-Modified Materials, (Eds. S. J. Clarson, J. J. Fitzgerald, M. J. Owen, S. D. Smith and M. E. Van Dyke), ACS Symposium Series Vol 838 / Oxford University Press, 2003, ISBN 0-8412-3804-9

The American Chemical Society Committee on Analytical Reagents is the only organization in the world that sets requirements and develops validated methods for determining the purity of analytical reagents. For the first time, Reagent Chemicals, 10th Edition includes general physical properties and analytical uses for all reagent chemicals, nearly 500 chemicals. Thirty-two new reagents and three new classes of standard grade reference materials are introduced in this edition. In addition, the use of Inductively Coupled Plasma Mass Spectrometry (ICP-MS), which is recognized as the most powerful and flexible trace element technique, is now accepted as an analytical method in the 10th edition. Other improvements include a CAS number index, a separate index for standard grade reference materials, updated atomic weights, frequently used mathematical equations, complete assay calculations with titer values, a tutorial on how to read a monograph, and detailed tables of contents introducing each section.