This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

"WHAT DOES NOT NEED TO BE BIG, WILL BE SMALL," a word by an engineer at a recent conference on chips technology. This sentence is particularly true for chemistry. Microfabrication technology emerged from microelectronics into areas like mechanics and now chemistry and biology. The engineering of micron and submicron sized features on the surface of silicon, glass and polymers opens a whole new world. Micromotors smaller than human hair have been fabricated and they work fine. It is the declared goal of the authors to bring these different worlds together in this volume. Authors have been carefully chosen to guarantee for the quality of the contents. An engineer, a chemist or a biologist will find new impulses from the various chapters in this book.

Microbial Lipids: Processes, Products, and Innovations brings together experienced authors on microbial lipids bioproduction, introducing the reader to key aspects from lipid chemistry and biochemistry to industrial production by fungi, yeast and microalgae. Intended for professionals in industry-oriented research and development, this volume also describes lipid production using synthetic media and agroindustry residues and discusses the potential of integration of microbial lipids in biorefineries, towards a circular economy. With a market of US$ 7 billion, oils and fats are one of the most important classes of natural products, with applications in food, feed, nutraceuticals, cosmetics, biofuel, and oleo chemistry. Primary sources include plants, animals and fish. However, specialty lipids such as oils rich in omega-3 and -6 fatty acids have limited sources and productivity. Microbial oils are gaining space in the global market as green - and even vegan - alternatives to traditional sources. Microorganisms also have high productivity and metabolic plasticity which makes it promising sources of new products.

This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.

Purification of Laboratory Chemicals: Part One, Physical Techniques, Chemical Techniques, Organic Chemicals, Ninth Edition describes contemporary methods for the purification of chemical compounds. The work includes tabulated methods taken from literature for purifying thousands of individual commercially available chemical substances. To help in applying this information, the more common processes currently used for purification in chemical laboratories and new methods are discussed. For dealing with substances not separately listed, another chapter is included, setting out the usual methods for purifying specific classes of compounds. Laboratory workers, whether carrying out research or routine work, will invariably need to consult this book. Apart from the procedures described, the large amount of physical data about listed chemicals is essential. This fully updated, revised and expanded new edition includes the purification of many new substances that have been available commercially since 2017, along with previously available substances which have found new applications.

Biocatalysis in Oil Refining focuses on petroleum refining bioprocesses, establishing a connection between science and technology.
The micro organisms and biomolecules examined for biocatalytic purposes for oil refining processes are thoroughly detailed. Terminology used by biologists, chemists and engineers is brought into a common language, aiding the understanding of complex biological-chemical-engineering issues. Problems to be addressed by the future R&D activities and by new technologies are described and summarized in the last chapter.
* Updated references
* Studying bioprocessing problems, looking at opportunities for improvements and technology developments

Designer Microbial Cell Factories: Metabolic Engineering and Applications, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a detailed overview of the biotechnological approaches and strategies used to generate engineered microbes and to facilitate the acceleration, modulation and diversion of metabolic pathways to get desired output such as production of value-added compound or biodegradation of xenobiotic pollutant. The book also highlights applied aspects of designer microbes in fields as diverse as agriculture, pharmaceuticals and bioremediation. Designer microbes generated through reprogramming the microbial cell factories (MCFs) provide an edge over their natural counterparts in terms of increased molecular diversity and selective chemistry. These bugs are becoming instrumental in several areas, including agriculture, environment and human health. Engineering microbes through directed evolution not only gives freedom from evolutionary constrains but also allow introduction of regulated and foreseeable functions into MCFs.

The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. The importance of the IGF system is underscored by the significant interest in the development of anti-IGF therapies for IGF sensitive cancers. Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells. 14. Acknowledgements We would like to thank Kurt Tidmore for preparing the illustrations. The Health Research Board of Ireland and Science Foundation Ireland are grateful acknowledged for funding. 15. References Adamo M., Roberts C. T., Jr. and LeRoith D. (1992) How distinct are the insulin and insul- like growth factor I signalling systems? Biofactors 3, 151-7. Adams T. E., Epa V. C., Garrett T. P. and Ward C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050-93. Adler V., Polotskaya A., Wagner F. and Kraft A. S. (1992) Affinity-purified c-Jun ami- terminal protein kinase requires serine/threonine phosphorylation for activity. J Biol Chem 267, 17001-5.

There is hardly a technical library in the world in which the volumes of the Chemical Formulary (Volumes 1-34) do not occupy a prominent place. It does not duplicate any of the formulas included in previous volumes, but lists a wide array of modern and salable products from all branches of the chemical industries. An excellent reference for formulation problems. - CONTENTS - I. Introduction - II. Adhesives - III. Foods and Beverages - IV. Cosmetics - V. Coatings - VI. Detergents - VII. Drugs - VIII. Metal Treatments - IX. Polishes - X. Elastomers, Polymers and Resins - Xl. Miscellaneous - Appendix - Index - PREFACE - Chemistry, as taught in our schools and colleges, concerns chiefly synthesis, analysis, and engineering-and properly so. It is part of the right foundation for the education of the chemist. Many a chemist entering an Industry soon finds that most of the products manufactured by his concern are not synthetic or definite complex compounds, but are mixtures, blends, or highly complex compounds of which he knows little or nothing. The literature in this field, if any, may be meager, scattered, or obsolete. Even chemists with years of experience In one or more Industries spend conslderable time and effort in acquainting themselves with any new field which they may enter. Consulting chemists similarly have to solve problems brought to them from industries foreign to them. There was a definite need for an up-to-date compilation of formulae for chemical compounding and treatment. Since the fields to be covered are many and varied, an editorial board of chemists and engineers engaged in many industries was formed. Many publications, laboratories, manufacturing firms, and Individuals have been consulted to obtain the latest and best information. It is felt that the formulas given in this volume will save chemists and allied workers much time and effort.

Almost all the major accident investigations--Texas City, Piper Alpha, the Phillips 66 explosion, Feyzin, Mexico City--show human error as the principal cause, either in design, operations, maintenance, or the management of safety. This book provides practical advice that can substantially reduce human error at all levels. In eight chapters--packed with case studies and examples of simple and advanced techniques for new and existing systems--the book challenges the assumption that human error is "unavoidable." Instead, it suggests a systems perspective. This view sees error as a consequence of a mismatch between human capabilities and demands and inappropriate organizational culture. This makes error a manageable factor and, therefore, avoidable.

The objective of the Springer Handbook of Enzymes is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. Each volume comprises one enzyme class, sometimes the enzyme classes have to be divided into several volumes. Considerable progress has been made in enzymology since the publication of the first edition (published as "Enzyme Handbook"): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: "application" and "engineering" (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of 39 volumes plus synonym index. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.

The objective of the Springer Handbook of Enzymes is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. Each volume comprises one enzyme class, sometimes the enzyme classes have to be divided into several volumes. Considerable progress has been made in enzymology since the publication of the first edition (published as "Enzyme Handbook"): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: "application" and "engineering" (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of 39 volumes plus synonym index. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.

Foaming with Supercritical Fluids, Volume Nine provides a comprehensive description of the use of supercritical fluids as blowing agents in polymer foaming. To this aim, the fundamental issues on which the proper design and control of this process are rooted are discussed in detail, with specific attention devoted to the theoretical and experimental aspects of sorption thermodynamics of a blowing agent within a polymer, the effect of the absorbed blowing agent on the thermal, interfacial and rheological properties of the expanding matter, and the phase separation of the gaseous phase, and of the related bubble nucleation and growth phenomena. Several foaming technologies based on the use of supercritical blowing agents are then described, addressing the main issues in the light of the underlying chemical-physical phenomena.

The contrasting examples of microwave plasmas given in this volume demonstrate their capability of not only covering the totality of expressed needs in that particular field, but in many others. For example the ions and reactive neutral species, indispensable for the synergetic effects in etching and deposition processes can be used in metallurgical treatment, and for materials processing in general. They also have the ability to dissociate molecules and excite atoms as required in analytical chemistry where the information on the constituent concentrations is obtained through optical spectroscopy or mass spectrometry. Finally, microwave plasmas can supply the photons for laser and lighting applications. It is noteworthy that microwave plasmas cover an impressive pressure range of eight orders of magnitude from 10-3 Pa (10-5 torr) to above atmospheric pressure. The versatility of microwave plasmas, their moderate cost, and their ease of implementation particularly appeal to the industrial entrepreneur.

As well as providing a review of current developments, the work proposes a synthesis on microwave discharges, laying out the corresponding physical references without developing too much plasma theory. It will be of interest both to the user, who may not be overly concerned about plasma science, and to the plasma expert, who may wish to redirect his interest towards plasma applications, such as materials processing.

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

Systems analysis for sustainability is an emerging discipline where technologies, processes or policies are evaluated comprehensively for sustainability. Trifold sustainability metrics such as technical feasibility, economic viability and environmental impacts are commonly used to assess sustainability. In addition to these metrics, it is important to consider resource sustainability, policies and social aspects for evaluating the sustainability of any proposed alternative. Green-Economy: Systems Analysis for Sustainability provides a theoretical background to perform such analyses and detailed case studies. The first part of this book introduces methods and tools to perform technical feasibility analysis, economic viability analysis, environmental impacts assessment, environmental risk assessment, resource sustainability assessment, policy and social aspects of technologies, general logic-based sustainability assessment for green products and introduces resilience thinking. The second part of the book focuses on case studies with an emphasis on solar energy, biofuels and bioproducts from across the globe.

CONTENTS - Preface - Contributors - Abbreviations - Introduction - I. Antiperspirants and Deodorants - II. Hair Products - III. Bath Preparations - IV. Face and Hand Cleaners - V. Face, Eye, and Body Makeup - VI. Creams and Lotions - VII. Mouth Preparations - VIII. Perfumes, Colognes, and Powders - IX. Shaving Preparations - X. Sunscreen Products - XI. Miscellaneous - Appendix - pH Values - pH Ranges of Common Indicators - International Atomic Weights - Temperature Conversion Tables - Incompatible Chemicals - Safety in the Laboratory or Home Workshop - General Laboratory Equipment - Aerosols - Trademark Chemical Manufacturers - Trademark Chemicals - Index - PREFACE - The growth of the cosmetic industry in the U.S.A. is a prime example of the dynamics of industry. From 1914 to 1966 the retail cosmetic sales within the U.S.A. went from almost $40 million to well over $3 billion. Part of the reason for this upsurge can be attributed to the increased interest shown by men in cosmetic products such as various shaving creams, colognes, hair tonics and conditioners. Because of the importance of this field of chemical science, it seemed pertinent to produce a chemical formulary specializing in cosmetic preparations of all types. The formulas and data in this book have all been contributed within the past twelve months by the companies listed on page iv They are printed as contributed and thus there are variations in manner of presentation. The formulas included here are of an experimental nature and are intended to be used as starting points for the industrial chemist, and for those who wish to experiment in their own right. Many of the formulas can serve as successful products without any alterations required. However, once the chemist has familiarized himself with the formulas as they stand, the adventure of individual experimentation begins. All data is based on U.S. Specification and practice, but readers in other countries should not find it difficult to adapt the formulas for their own use.

Natural Polymers-Based Green Adsorbents for Water Treatment focuses on the recent development of novel polymeric adsorbents that are green and eco-friendly or biodegradable in nature. The book reviews the synthesis, properties and adsorption applications of natural and green polymer-based adsorbents. It discusses adsorption processes in biopolymer systems, remediation technologies developed to remove environmental pollutants, the usage of natural polymer-based cost-effective and green novel adsorbent materials for the removal of organic and inorganic contaminants, and the efficiency of functionalized polymers, nanosorbents, hydrogels, composites, graft copolymers in the sorption of various pollutants from the environment as well as from the industrial effluents. Researchers working on environmental remediation need a single book, where all data on natural and green adsorbents for water treatment are discussed comprehensively. Natural Polymers-Based Green Adsorbents for Water Treatment addresses this need by providing world-wide leading experts' observations and research. So, this book is a valuable reference for early-career scientist, academic researchers and graduate students in chemical engineering and material science.