The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. The importance of the IGF system is underscored by the significant interest in the development of anti-IGF therapies for IGF sensitive cancers. Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells. 14. Acknowledgements We would like to thank Kurt Tidmore for preparing the illustrations. The Health Research Board of Ireland and Science Foundation Ireland are grateful acknowledged for funding. 15. References Adamo M., Roberts C. T., Jr. and LeRoith D. (1992) How distinct are the insulin and insul- like growth factor I signalling systems? Biofactors 3, 151-7. Adams T. E., Epa V. C., Garrett T. P. and Ward C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050-93. Adler V., Polotskaya A., Wagner F. and Kraft A. S. (1992) Affinity-purified c-Jun ami- terminal protein kinase requires serine/threonine phosphorylation for activity. J Biol Chem 267, 17001-5.

There is hardly a technical library in the world in which the volumes of the Chemical Formulary (Volumes 1-34) do not occupy a prominent place. It does not duplicate any of the formulas included in previous volumes, but lists a wide array of modern and salable products from all branches of the chemical industries. An excellent reference for formulation problems. - CONTENTS - I. Introduction - II. Adhesives - III. Foods and Beverages - IV. Cosmetics - V. Coatings - VI. Detergents - VII. Drugs - VIII. Metal Treatments - IX. Polishes - X. Elastomers, Polymers and Resins - Xl. Miscellaneous - Appendix - Index - PREFACE - Chemistry, as taught in our schools and colleges, concerns chiefly synthesis, analysis, and engineering-and properly so. It is part of the right foundation for the education of the chemist. Many a chemist entering an Industry soon finds that most of the products manufactured by his concern are not synthetic or definite complex compounds, but are mixtures, blends, or highly complex compounds of which he knows little or nothing. The literature in this field, if any, may be meager, scattered, or obsolete. Even chemists with years of experience In one or more Industries spend conslderable time and effort in acquainting themselves with any new field which they may enter. Consulting chemists similarly have to solve problems brought to them from industries foreign to them. There was a definite need for an up-to-date compilation of formulae for chemical compounding and treatment. Since the fields to be covered are many and varied, an editorial board of chemists and engineers engaged in many industries was formed. Many publications, laboratories, manufacturing firms, and Individuals have been consulted to obtain the latest and best information. It is felt that the formulas given in this volume will save chemists and allied workers much time and effort.

This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.

Almost all the major accident investigations--Texas City, Piper Alpha, the Phillips 66 explosion, Feyzin, Mexico City--show human error as the principal cause, either in design, operations, maintenance, or the management of safety. This book provides practical advice that can substantially reduce human error at all levels. In eight chapters--packed with case studies and examples of simple and advanced techniques for new and existing systems--the book challenges the assumption that human error is "unavoidable." Instead, it suggests a systems perspective. This view sees error as a consequence of a mismatch between human capabilities and demands and inappropriate organizational culture. This makes error a manageable factor and, therefore, avoidable.

This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.

The objective of the Springer Handbook of Enzymes is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. Each volume comprises one enzyme class, sometimes the enzyme classes have to be divided into several volumes. Considerable progress has been made in enzymology since the publication of the first edition (published as "Enzyme Handbook"): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: "application" and "engineering" (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of 39 volumes plus synonym index. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.

The contrasting examples of microwave plasmas given in this volume demonstrate their capability of not only covering the totality of expressed needs in that particular field, but in many others. For example the ions and reactive neutral species, indispensable for the synergetic effects in etching and deposition processes can be used in metallurgical treatment, and for materials processing in general. They also have the ability to dissociate molecules and excite atoms as required in analytical chemistry where the information on the constituent concentrations is obtained through optical spectroscopy or mass spectrometry. Finally, microwave plasmas can supply the photons for laser and lighting applications. It is noteworthy that microwave plasmas cover an impressive pressure range of eight orders of magnitude from 10-3 Pa (10-5 torr) to above atmospheric pressure. The versatility of microwave plasmas, their moderate cost, and their ease of implementation particularly appeal to the industrial entrepreneur.

As well as providing a review of current developments, the work proposes a synthesis on microwave discharges, laying out the corresponding physical references without developing too much plasma theory. It will be of interest both to the user, who may not be overly concerned about plasma science, and to the plasma expert, who may wish to redirect his interest towards plasma applications, such as materials processing.

The objective of the Springer Handbook of Enzymes is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. Each volume comprises one enzyme class, sometimes the enzyme classes have to be divided into several volumes. Considerable progress has been made in enzymology since the publication of the first edition (published as "Enzyme Handbook"): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: "application" and "engineering" (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of 39 volumes plus synonym index. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.

CONTENTS - Preface - Contributors - Abbreviations - Introduction - I. Antiperspirants and Deodorants - II. Hair Products - III. Bath Preparations - IV. Face and Hand Cleaners - V. Face, Eye, and Body Makeup - VI. Creams and Lotions - VII. Mouth Preparations - VIII. Perfumes, Colognes, and Powders - IX. Shaving Preparations - X. Sunscreen Products - XI. Miscellaneous - Appendix - pH Values - pH Ranges of Common Indicators - International Atomic Weights - Temperature Conversion Tables - Incompatible Chemicals - Safety in the Laboratory or Home Workshop - General Laboratory Equipment - Aerosols - Trademark Chemical Manufacturers - Trademark Chemicals - Index - PREFACE - The growth of the cosmetic industry in the U.S.A. is a prime example of the dynamics of industry. From 1914 to 1966 the retail cosmetic sales within the U.S.A. went from almost $40 million to well over $3 billion. Part of the reason for this upsurge can be attributed to the increased interest shown by men in cosmetic products such as various shaving creams, colognes, hair tonics and conditioners. Because of the importance of this field of chemical science, it seemed pertinent to produce a chemical formulary specializing in cosmetic preparations of all types. The formulas and data in this book have all been contributed within the past twelve months by the companies listed on page iv They are printed as contributed and thus there are variations in manner of presentation. The formulas included here are of an experimental nature and are intended to be used as starting points for the industrial chemist, and for those who wish to experiment in their own right. Many of the formulas can serve as successful products without any alterations required. However, once the chemist has familiarized himself with the formulas as they stand, the adventure of individual experimentation begins. All data is based on U.S. Specification and practice, but readers in other countries should not find it difficult to adapt the formulas for their own use.

This book provides in-depth coverage on the latest concepts, systems, and technologies that are being utilized in biorefineries for the production of biofuels and value-added commodities. Written by internationally recognized experts, the book provides a comprehensive overview of pretreatment technology for biorefineries and biofuels, enzymatic hydrolysis and fermentation technology for biofuel production, and lignin valorization for developing new products from waste lignin. The book will be a valuable resource for researchers and professionals working in process engineering, product engineering, material science, and systems and synthetic biology in the fields of biorefining, biofuel, biomaterials, environmental waste utilization, and biotechnology.

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions. Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful.

This book presents the fundamentals of the reservoir and interfacial engineering. The book systematically starts with the basics of primary, secondary and tertiary (enhanced) oil recovery and emphasizes on the theory of microbial-enhanced oil recovery (MEOR) and its potential toward recovery of oil in place. Different approaches of MEOR such as in-situ, ex-situ, and integration of chemical- and microbial-enhanced oil recovery (EOR) are discussed in detail. This book highlights the link between the effectiveness of MEOR and the local reservoir conditions, crude oil characteristics, and indigenous microbial community. The latest implementations of MEOR across the globe are highlighted as case studies to outline the potential as well as the scope of MEOR. Given the topics covered, this book will be useful for professionals and researchers working in the areas of petroleum science and engineering, chemical engineering, biotechnology, bioengineering, and other related fields.

This book investigates processes to reduce environmental pollution and polyurethane (PU) waste going to landfill. The author explains recycling approaches as well as instrumental methods such as nuclear magnetic resonance (NMR) spectroscopy and Fourier-Transform infrared spectroscopy for characterization and identification of PU recycling products.

This is a concise book with comprehensive information on coal and biomass ash generated from their combustion in thermal power plants. It presents detailed studies on ash generated from contrasting coal and biomass feedstocks, and provides a comparative evaluation of these different ashes in terms of their origin, properties, environmental hazards. Potential utilizations with specific advantages and disadvantages of the respective ashes are elaborated in detail, including some innovative means of ash utilization for value addition purposes. By addressing both the theory and commercial exploitation of these products, this book will be helpful for industrialists, academicians and researchers alike.

This book provides an updated and detailed overview on the recent developments of bioethanol technology. It looks at the historical perspectives, chemistry, sources and production of ethanol and discusses biotechnology breakthroughs and promising developments, its uses, advantages, problems, environmental effects and characteristics. In addition, it presents information about ethanol in different parts of the world and also highlights the challenges and future of ethanol. The first edition of this book was published as a SpringerBriefs in 2013. Since then, many new developments have taken place in the last six years. This new edition will highlight the evolution in bioethanol development from first-generation production to the futuristic fourth-generation bioethanol production, the various constraints and challenges involved, and the scope for development. This book caters to the audience who are interested in alternative transportation fuels which are both biodegradable and sustainable to the environment.

This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs. It also provides insights into the development of the biologically functionalized ionic liquids suitable for medical and pharmaceutical applications. Ionic liquids have been used as potential solvents or materials in the fields of pharmaceutical drug delivery and formulations because of their unique and tunable physicochemical and biological properties. Readers find explanations of the diverse approaches to the application of ionic liquids in drug solubility, active pharmaceutical ingredient (API) formulation, and drug delivery systems, such as topical, transdermal, and oral delivery, with particular emphasis on recent developments. Particular attention is given to the development of ionic liquid-assisted effective drug delivery techniques for sparingly soluble or insoluble drug molecules. This book also discusses the biological activities of ionic liquids for possible applications in drug formulation and drug delivery systems. Scientists in disciplines such as chemistry, biology, and pharmaceutics find this book instructive and informative for developing ionic liquid-based drug formulations or drug delivery systems.

Process Safety Calculations, Second Edition remains to be an essential guide for students and practitioners in process safety engineering who are working on calculating and predicting risks and consequences. The book focuses on calculation procedures based on basic chemistry, thermodynamics, fluid dynamics, conservation equations, kinetics and practical models. It provides helpful calculations to demonstrate compliance with regulations and standards, such as Seveso directive(s)/COMAH, CLP regulation, ATEX directives, PED directives, REACH regulation, OSHA/NIOSH and UK ALARP, along with risk and consequence assessment, stoichiometry, thermodynamics, stress analysis and fluid-dynamics. This fully revised, updated and expanded second edition follows the same organization as the first, including the original three main parts, Fundamentals, Consequence Assessment and Quantitative Risk Assessment. However, the latter part is significantly expanded, including an appendix consisting of five fundamental thematic areas belonging to the risk assessment framework, including in-depth calculations methodologies for some fundamental monothematic macro-areas of process safety.

Green Sustainable Process for Chemical and Environmental Engineering and Science: Green Solvents for Biocatalysis delivers an in-depth overview of biocatalysis in green solvents for industrial applications, also including outlines of sustainable methodologies in the area of organic chemistry, agriculture, analytical chemistry and engineering and pharmaceutical sciences. The book provides unique content in the area, making it a great source for information for undergraduate, postgraduate students, faculty, R&D professionals, production chemists, environmental engineers and industrial experts.