This book illustrates how models of chemical reactors are built up in a systematic manner, step by step. The authors also outline how the numerical solution algorithms for reactor models are selected, as well as how computer codes are written for numerical performance, with a focus on MATLAB and Fortran. Examples solved in MATLAB and simulations performed in Fortran are included for demonstration purposes.

Fundamentals of Electrical Engineering is an excellent introduction into the areas of electricity, electronic devices and electrochemistry. The book covers aspects of electrical science including Ohm and Kirkoff's laws, P-N junctions, semiconductors, circuit diagrams, magnetic fields, electrochemistry, and devices such as DC motors. This text is useful for students of electrical, chemical, materials, and mechanical engineering.

The book supplements "Guidelines for Chemical Process Quantitative Risk Analysis" by providing the failure rate data needed to perform a chemical process quantitative risk analysis.

This book provides a framework for the development of sustainable bioprocesses. It includes methods for modeling and assessing both the economic and environmental aspects of biotechnological processes and illustrates their application in a series of case studies covering a broad range of products.

The book: provides, in four chapters, an introduction to bioproducts and bioprocesses and the unit operations involved in manufacturing, as well as bioprocess modeling in combination with economic and environmental assessment methods; cuts across multiple process industries, including pharmaceutical, biochemicals, chemicals and food production; addresses risk and uncertainty analysis which are particularly important in early process and product development; presents a unique set of case examples from various parts of biotechnology that improve the understanding of this technology and provide a starting point for developing a specific model.

The CD-ROM included contains the process models described in the text. All process model examples are implemented into SuperPro Designer a. The models are selected as characteristic examples of major bioprocess applications including bulk bio-chemicals, fine chemicals, enzymes, low and high molecular weight pharmaceuticals. Topics covered are: Citric Acid, Pyruvic Acid, L-Lysine, Riboflavin - Vitamin B2, α-Cyclodextrin, Penicillin V, Recombinant Human Serum Albumin, Recombinant Human Insulin; Monoclonal Antibodies, α-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures and Plasmid DNA production. These examples provide a hands-on-approach, which will be useful to both students and professionals already working in bioprocessindustries.

This book provides an integrating framework for the student in chemical and biochemical engineering and the scientist and engineer engaged in process development working in the biochemical, chemical and process industries, as well as biologists, chemists, environmental managers and business economists.

The authors acknowledge the sponsorship of the Deutsche Bundesstiftung Umwelt, Osnabruck, Germany.

This books provides a compendium of electrospinning strategies and related technologies for the production of biomaterials for tissue engineering and regenerative medicine applications. It gives a broad overview of the field as well as cutting-edge research on electrospinning and how it is applied to engineer biomaterials. This is an ideal book for biomaterials scientists, engineers, students, and researchers. This book also: Presents cutting-edge research performed in the area of electrospinning with applications in tissue engineering and regenerative medicine Provides readers from the biomaterials field as well as those new to the field with a broad overview of the multiple applications of electrospun biomaterials Summarizes the latest research from the past ten years on electrospinning and related technologies

This book covers the history, theory, and practice of bonding elastomers to solid substrates. It provides information of methods, equipment, and bond evaluation. Numerous detailed examples of research into the variables that affect bonding, bond strength, and bond durability are provided to give the reader deeper understanding of this technology.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Product-driven process design - from molecule to enterprise provides process engineers and process engineering students with access to a modern and stimulating methodology to process and product design. Throughout the book the links between product design and process design become evident while the reader is guided step-by-step through the different stages of the intertwining product and process design activities. Both molecular and enterprise-wide considerations in design are introduced and addressed in detail. Several examples and case studies in emerging areas such as bio- and food-systems, pharmaceuticals and energy are discussed and presented. This book is an excellent guide and companion for undergraduate, graduate students as well as professional practitioners.

The book illuminates various aspects of heterogeneous catalysis engineering, from catalysis design, catalyst preparation and characterization, reaction kinetics, mass transfer, and catalytic reactors to the implementation of catalysts in chemical technology. Aimed at graduate students, it is also a useful resource for professionals working in research and development.

The book presents selected, extended and peer reviewed papers from the International Multiconference on System, Automation and Control held Leipzig in 2018. These are complemented with solicited contributions by international experts. Main topics are automatic control, robotics, synthesis of automation systems. Application examples range from man-machine interaction, mechatronics, on to biological and economical models.

Since its inception in 2002, the Central European Food Congress (CEFood) has been a biannual meeting intended for food producers and distributors as well as researchers and educators to promote research, development, innovation and education within food science and technology in the Middle European region with a tight connection to global trends. The 6th CEFood, held in Novi Sad, Serbia, May 23-26, 2012, highlighted the novel technologies and traditional foods aimed at both the European and global markets. Specifically, CEFood 2012 focused on the latest progress in fundamental and applied food science, research and development, innovative technology, food ingredients, novel trends in nutrition and health, functional and bioactive food, food engineering, food safety and quality and the food and feed market. This book will consist of contributions from various presenters at CEFood 2012, covering the major themes of this Congress. Chapters contributed by expert presenters from the 6th CEFood Congress of 2012 Highlights the novel technologies of food science Discusses the future of the food industry and food research

This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules - a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally - which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.

This book discusses recent trends and developments in the microbial conversion process, which serves as an important route for biofuel production, with particular attention to bioreactors. It combines microbial conversion with multiphase flow and mass transfer, providing an alternative perspective for the understanding of microbial biomass and energy production process as well as enhancement strategy. This book is relevant to students and researchers who work in the fields of renewable energy, engineering and biotechnology. Policymakers, economists and industry engineers also benefit from this book, as it can be used as a resource for the implementation of renewable energy technologies.

This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter. Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under live cell conditions. Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.

The conversion of CO2 to chemicals and consumables is a pioneering approach to utilize undesired CO2 emissions and simultaneously create new products out of sustainable feedstock. Volume 1 gives an introduction to CO2 chemistry, utilisation and sustainability and further discusses its capture and separation. Both volumes are also included in a set ISBN 978-3-11-066549-9.

This book provides a comprehensive description of theories and applications of high-solid and multi-phase bioprocess engineering, which is considered as an important way to address the challenges of "high energy consumption, high pollution and high emissions" in bio-industry. It starts from specifying the solid-phase matrix properties that contribute to a series of "solid effects" on bioprocess, including mass transfer restrictions in porous media, water binding effects, rheological changes. Then it proposes the new principles of periodic intensification which combines the normal force and physiologic characteristics of microorganism for the bioprocess optimization and scale-up. Further breakthroughs in key periodic intensification techniques such as periodic peristalsis and gas pressure pulsation are described in detail which provide an industrialization platform and lay the foundation for high-solid and multi-phase bioprocess engineering. This book offers an excellent reference and guide for scientists and engineers engaged in the research on both the theoretical and practical aspects of high-solid and multi-phase bioprocess.

The conversion of CO2 to chemicals and consumables is a pioneering approach to utilize undesired CO2 emissions and simultaneously create new products out of sustainable feedstock. Volume 2 describes several routes to transform CO2 into various compounds by catalytic and electrochemical as well as photo- and plasma induced reactions. Both volumes are also included in a set ISBN 978-3-11-066549-9.

"Cell and Tissue Engineering" introduces the principles and new approaches in cell and tissue engineering. It includes both the fundamentals and the current trends in cell and tissue engineering, in a way useful both to a novice and an expert in the field. The book is composed of 13 chapters all of which are written by the leading experts. It is organized to gradually assemble an insight in cell and tissue function starting form a molecular nano-level, extending to a cellular micro-level and finishing at the tissue macro-level. In specific, biological, physiological, biophysical, biochemical, medical, and engineering aspects are covered from the standpoint of the development of functional substitutes of biological tissues for potential clinical use. Topics in the area of cell engineering include cell membrane biophysics, structure and function of the cytoskeleton, cell-extracellular matrix interactions, and mechanotransduction. In the area of tissue engineering the focus is on the in vitro cultivation of functional tissue equivalents based on the integrated use of isolated cells, biomaterials, and bioreactors. The book also reviews novel techniques for cell and tissue imaging and characterization, some of which are described in detail such as atomic force microscopy. Finally, mathematical modeling methods are presented as valuable and indispensable tools in cell and tissue engineering. Numerous illustrations enhance the quality and ease of use of the presented material.

The "greening" of industry processes - i.e., making them more sustainable - is a popular and often lucrative trend which has seen increased attention in recent years. Green Chemical Processes, the 2nd volume of Green Chemical Processing, covers the hot topic of sustainability in chemistry with a view to education, as well as considering corporate and environmental interests, e.g. in the context of energy production. The diverse team of authors allows for a balance between these different, but interconnected perspectives. The American Chemical Society's 12 Principles of Green Chemistry are woven throughout this text as well as the series to which this book belongs.

The Separable Galois Theory of Commutative Rings, Second Edition provides a complete and self-contained account of the Galois theory of commutative rings from the viewpoint of categorical classification theorems and using solely the techniques of commutative algebra. Along with updating nearly every result and explanation, this edition contains a new chapter on the theory of separable algebras. The book develops the notion of commutative separable algebra over a given commutative ring and explains how to construct an equivalent category of profinite spaces on which a profinite groupoid acts. It explores how the connection between the categories depends on the construction of a suitable separable closure of the given ring, which in turn depends on certain notions in profinite topology. The book also discusses how to handle rings with infinitely many idempotents using profinite topological spaces and other methods.

Featuring in-depth discussions on tensile and compressive properties, shear properties, strength, hardness, environmental effects, and creep crack growth, "Mechanical Properties of Engineered Materials" considers computation of principal stresses and strains, mechanical testing, plasticity in ceramics, metals, intermetallics, and polymers, materials selection for thermal shock resistance, the analysis of failure mechanisms such as fatigue, fracture, and creep, and fatigue life prediction. It is a top-shelf reference for professionals and students in materials, chemical, mechanical, corrosion, industrial, civil, and maintenance engineering; and surface chemistry.

This Volume presents a comprehensive series of generic protocols for the genetic and genomic analysis of prokaryotic isolates. Genetic methods for functional analyses employ the latest cloning vectors, gene fusion methods and transposon mutagenesis systems, as well as systems for introducing protease-cleavage sequences into permissive sites in proteins under investigation. Genomic methods described include protocols for transcriptomics, shotgun proteomics, interactomics, metabolic profiling, and lipidomics. Bioinformatic tools for genome annotation, transcriptome display and the integration of transcriptomic data into genome-scale metabolic reconstructions are described. Protocols for 13C-based metabolic flux determinations and analysis of the hierarchical and metabolic regulation of fluxes through pathways are included. The Volume thus enables investigators to functionally analyse an isolate over the entire cellular range spanning the gene, the genome, the transcript repertoire, the proteome, the interactome, the metabolic network with its nodes and their regulatory hierarchies, and the metabolic fluxes and their physiological controls. Hydrocarbon and Lipid Microbiology Protocols There are tens of thousands of structurally different hydrocarbons, hydrocarbon derivatives and lipids, and a wide array of these molecules are required for cells to function. The global hydrocarbon cycle, which is largely driven by microorganisms, has a major impact on our environment and climate. Microbes are responsible for cleaning up the environmental pollution caused by the exploitation of hydrocarbon reservoirs and will also be pivotal in reducing our reliance on fossil fuels by providing biofuels, plastics and industrial chemicals. Gaining an understanding of the relevant functions of the wide range of microbes that produce, consume and modify hydrocarbons and related compounds will be key to responding to these challenges. This comprehensive collection of current and emerging protocols will facilitate acquisition of this understanding and exploitation of useful activities of such microbes.

This book aims at presenting, describing, and summarizing the latest advances in polymer flooding regarding the chemical synthesis of the EOR agents and the numerical simulation of compositional models in porous media, including a description of the possible applications of nanotechnology acting as a booster of traditional chemical EOR processes. A large part of the world economy depends nowadays on non-renewable energy sources, most of them of fossil origin. Though the search for and the development of newer, greener, and more sustainable sources have been going on for the last decades, humanity is still fossil-fuel dependent. Primary and secondary oil recovery techniques merely produce up to a half of the Original Oil In Place. Enhanced Oil Recovery (EOR) processes are aimed at further increasing this value. Among these, chemical EOR techniques (including polymer flooding) present a great potential in low- and medium-viscosity oilfields. * Describes recent advances in chemical enhanced oil recovery. * Contains detailed description of polymer flooding and nanotechnology as promising boosting tools for EOR. * Includes both experimental and theoretical studies. About the Authors Patrizio Raffa is Assistant Professor at the University of Groningen. He focuses on design and synthesis of new polymeric materials optimized for industrial applications such as EOR, coatings and smart materials. He (co)authored about 40 articles in peer reviewed journals. Pablo Druetta works as lecturer at the University of Groningen (RUG) and as engineering consultant. He received his Ph.D. from RUG in 2018 and has been teaching at a graduate level for 15 years. His research focus lies on computational fluid dynamics (CFD).

This Volume describes methods for simulating natural environments by using reproducible and controllable meso- and microcosm experiments to analyse hydrocarbon-degrading microorganisms and to test hypotheses. It presents important aspects of the preparation of experimental set-ups, hydrocarbon application and sampling, and features protocols for experiments with different types of samples, such as biofilms, aquatic systems (e.g. groundwater, streams), and sediments, including oscillating oxic-anoxic mesocosms, as well as for in-situ experimentation in subtidal and deep sediments. Two chapters are dedicated to cultivation under high-pressure conditions, and several chapters include protocols for processing samples for downstream chemical, microbial or activity analyses. Several of the approaches presented are generic and will benefit anyone embarking on designing meso- and microcosm experiments. < Hydrocarbon and Lipid Microbiology Protocols There are tens of thousands of structurally different hydrocarbons, hydrocarbon derivatives and lipids, and a wide array of these molecules are required for cells to function. The global hydrocarbon cycle, which is largely driven by microorganisms, has a major impact on our environment and climate. Microbes are responsible for cleaning up the environmental pollution caused by the exploitation of hydrocarbon reservoirs and will also be pivotal in reducing our reliance on fossil fuels by providing biofuels, plastics and industrial chemicals. Gaining an understanding of the relevant functions of the wide range of microbes that produce, consume and modify hydrocarbons and related compounds will be key to responding to these challenges. This comprehensive collection of current and emerging protocols will facilitate acquisition of this understanding and exploitation of useful activities of such microbes.

This book showcases the state of the art in the field of sensors and microsystems, revealing the impressive potential of novel methodologies and technologies. It covers a broad range of aspects, including: bio-, physical and chemical sensors; actuators; micro- and nano-structured materials; mechanisms of interaction and signal transduction; polymers and biomaterials; sensor electronics and instrumentation; analytical microsystems, recognition systems and signal analysis; and sensor networks, as well as manufacturing technologies, environmental, food and biomedical applications. The book gathers a selection of papers presented at the 19th AISEM National Conference on Sensors and Microsystems. Held in Lecce, Italy in February 2017, the event brought together researchers, end users, technology teams and policy makers.