Heterogeneous catalysis is undergoing a dramatic change driven by the need to develop more efficient catalyst systems for the production of specialty chemicals and the development of new high-tech materials. The traditional concept of a catalyst system consisting of finely divided metal particles dispersed on an inert amorphous ceramic support has encountered increased challenges. The chemical and physical phenomena that occur at the metal particle/support interface are looked at together with the detailed structural and crystallographic features of both components. Also of interest is the study of catalytic materials and the notion that the electronic properties of the substrate can be of extreme importance since they can influence not only the activity, but also the selectivity, of the catalytic systems. In this book, first published in 1998, scientists from very different disciplines have made contributions and brought insights to the field. Topics include: oxide catalysts; metal catalysts; carbon-based catalysts; pillared layered and porous catalysts; zeolited and related materials; acid and bases and surface modifications.

More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons.

The analysis and modification of glycans of recombinant proteins continues to be active and challenging area of research and for the successful manufacture of these proteins. In Cell Engineering, volume 3: Glycosylation, Dr. Mohammed Al-Rubeai has compiled a group of articles that will provide research workers not only with reviews of the advances that have been made in all facets of the subject but with an in-depth assessment of the state of the art methodology and the various approaches for the improvement of glycoprotein production. Particularly important in this respect is the advances made in the development of genetically engineered host cell lines with novel glycosylation properties, as well as the integration of mass spectrophotometric analysis with separation techniques.

This volume is intended not only for research students and senior scientists in cell culture and glycobiology, but also for industrial biotechnologists and biochemical engineers interested in the production of therapeutic glycoproteins, virus vector and ex vivo expansion of human cells for medical treatment.

Originally published in 2004, Distillation Theory and Its Application to Optimal Design of Separation Units presents a clear, multidimensional geometric representation of distillation theory that is valid for all distillation column types, splits, and mixtures. This representation answers such fundamental questions as: what are the feasible separation products for a given mixture? What minimum power is required to separate a given mixture? What minimum number of trays is necessary to separate a given mixture at a fixed power input? This book is intended for students and specialists in the design and operation of separation units in the chemical, pharmaceutical, food, wood, petrochemical, oil-refining, and natural gas industries and for software designers.

Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans. We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine.

Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.

Uses a large number of industrially-significant problems to convey an in-depth understanding of modern calculation procedures. Includes numerous topical examples and problems, and both conventional and SI units.

This book presents the development of modern molecular models for fluids from the interdisciplinary fundamentals of classical and statistical mechanics, of electrodynamics and of quantum mechanics. The concepts and working equations of the various fields are briefly derived and illustrated in the context of understanding the properties of molecular systems. Special emphasis is devoted to the quantum mechanical basis, since this is used throughout in the calculation of the molecular energy of a system. The book is application oriented. It stresses those elements that are essential for practical model development. The fundamentals are then used to derive models for various types of applications. Finally, equation of state models are presented based on quantum chemically based models for the intermolecular potential energy and perturbation theory. The book is suited for graduate courses in chemical and mechanical engineering, physics and chemistry, but may also, by proper selection, be found useful on the undergraduate level.

Drawing together topics from a wide range of disciplines, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine. Internationally renowned researchers showcase topics ranging from the basic physical principles of magnetism to the detection and manipulation, synthesis protocols and natural occurrence of magnetic nanoparticles. Up-to-date examples of their clinical usage and research applications in the biomedical fields of sensing by diverse magnetic detection methods, in imaging by MRI and in therapeutic strategies such as hyperthermia, are also discussed, providing a thorough introduction to this rapidly developing field. Each chapter features questions with answers, highlighted definition boxes, and numerous illustrations which help readers grasp key concepts. Mathematical tools, together with key literature references, provide a strong underpinning for the material, making it ideal for graduate students, lecturers, medical researchers and industrial scientific strategists.

Biomimetic sensor technology is based on the use of biomaterials and information processing of a type used in biological systems. This book explores biomimetic sensors that can quantify taste--the electronic tongue--and smell, the electronic nose. The development of these sensors contribute to our understanding of the reception mechanisms in gustatory and olfactory systems. The author, a pioneer in the development of this new technology, begins by describing the principles of measurement and multivariate analysis. He details reception mechanisms in biological systems and several types of biosensors, including enzyme-immobilized membranes, SPR, the quartz resonance oscillator and IC technologies. Dedicated to the development of intelligent sensors and systems, this original volume is an essential resource for engineers working in this vital research area.

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification Emphasizes antibodies and innovative chromatography methods for processing

Distillation Theory and Its Application to Optimal Design of Separation Units presents a clear, multidimensional geometric representation of distillation theory that is valid for all distillation column types, splits, and mixtures. This representation answers such fundamental questions as: - What are the feasible separation products for a given mixture? - What minimum power is required to separate a given mixture? - What minimum number of trays is necessary to separate a given mixture at a fixed power input? Concepts are reinforced by chapter exercises using free DistillDesigner software, which provides quick and reliable solutions to problems of flowsheet synthesis and to optimal design calculations. This software allows refinement and confirmation of the algorithms of optimal design. This book is intended for students and specialists in the design and operation of separation units in the chemical, pharmaceutical, food, wood, petrochemical, oil-refining, and natural gas industries and for software designers.

Lead-Acid Batteries: Science and Technology: A Handbook of Lead-Acid Battery Technology and Its Influence on the Product, Second Edition presents a comprehensive overview of the technological processes of lead-acid battery manufacture and their influence on performance parameters. The book summarizes current knowledge on lead-acid battery production, presenting it in the form of an integral theory that is supported by ample illustrative material and experimental data that allows technologists and engineers to control technological processes in battery plants. In addition, the book provides university lecturers with a tool for a clear and in-depth presentation of lead-acid battery production in courses. This updated edition includes new supplementary material (text and illustrations) in chapters 2, 4, 6 and 16, as well as a brand new chapter on the action of carbon as an additive to the negative active material and the utilization of the lead-carbon supercapacitor electrodes. Substantial revisions of other chapters have been made, making the book beneficial for battery researchers, engineers and technologists.

Concerned with discovering the chemical pathways of biosynthesis, this book devotes four chapters to the use of isotopes in biosynthetic research and the biosynthesis of enzyme cofactors and vitamin B12 and of reduced polyketides such as erythromycin. The topics covered demonstrate the revolution that has occurred in biosynthetic studies with the advent of gene cloning and overexpression. Yet the book also shows that the more classical approach to biosynthetic studies must go hand in hand with these new techniques.

The Leading Integrated Chemical Process Design Guide: With Extensive Coverage of Equipment Design and Other Key Topics More than ever, effective design is the focal point of sound chemical engineering. Analysis, Synthesis, and Design of Chemical Processes, Fifth Edition, presents design as a creative process that integrates the big-picture and small details, and knows which to stress when and why. Realistic from start to finish, it moves readers beyond classroom exercises into open-ended, real-world problem solving. The authors introduce up-to-date, integrated techniques ranging from finance to operations, and new plant design to existing process optimization. The fifth edition includes updated safety and ethics resources and economic factors indices, as well as an extensive, new section focused on process equipment design and performance, covering equipment design for common unit operations, such as fluid flow, heat transfer, separations, reactors, and more. Conceptualization and analysis: process diagrams, configurations, batch processing, product design, and analyzing existing processes Economic analysis: estimating fixed capital investment and manufacturing costs, measuring process profitability, and more Synthesis and optimization: process simulation, thermodynamic models, separation operations, heat integration, steady-state and dynamic process simulators, and process regulation Chemical equipment design and performance: a full section of expanded and revamped coverage of designing process equipment and evaluating the performance of current equipment Advanced steady-state simulation: goals, models, solution strategies, and sensitivity and optimization results Dynamic simulation: goals, development, solution methods, algorithms, and solvers Societal impacts: ethics, professionalism, health, safety, environmental issues, and green engineering Interpersonal and communication skills: working in teams, communicating effectively, and writing better reports This text draws on a combined 55 years of innovative instruction at West Virginia University (WVU) and the University of Nevada, Reno. It includes suggested curricula for one- and two-semester design courses, case studies, projects, equipment cost data, and extensive preliminary design information for jump-starting more detailed analyses.

Here is a comprehensive introduction to the highly practical and diverse applications of surfactants within the petroleum industry, detailing their nature, occurrence, physical properties, propagation, and uses. The focus is on the knowledge and practices needed to successfully deal with surfactants in the petroleum production process: in reservoirs, in oil and gas wells, in surface processing operations, and in environmental, health and safety applications. Throughout, important applications of colloid and interface science principles are emphasized and real-world processes and problems are clearly illustrated. The book also includes a comprehensive glossary.

Purification of Laboratory Chemicals: Part One, Physical Techniques, Chemical Techniques, Organic Chemicals, Ninth Edition describes contemporary methods for the purification of chemical compounds. The work includes tabulated methods taken from literature for purifying thousands of individual commercially available chemical substances. To help in applying this information, the more common processes currently used for purification in chemical laboratories and new methods are discussed. For dealing with substances not separately listed, another chapter is included, setting out the usual methods for purifying specific classes of compounds. Laboratory workers, whether carrying out research or routine work, will invariably need to consult this book. Apart from the procedures described, the large amount of physical data about listed chemicals is essential. This fully updated, revised and expanded new edition includes the purification of many new substances that have been available commercially since 2017, along with previously available substances which have found new applications.

Drawing on his own extensive experience, Jones provides rules of thumb essential for the new engineer in industry. Covering responsibilities such as project management, installation of new facilities and implementation of contracts, this book offers a wealth of experience and knowledge, helping newer process engineers to find a foothold in their chosen industry.

Containing over 1200 detailed equations and illustrations, Biochemical Engineering offers several features that make it an ideal textbook. For students. edifying worked-out examples problems thought-provoking end-of-chapter exercises helpful definitions of nomenclature a useful key word index For instructors.. outlines for an undergraduate 15-week semester course on biochemical engineering for students who have had an introductory class in biochemistry or a related biological science, or who are taking such a course concurrently additional or alternate topics for a graduate course for students without background in biological sciences and a timesaving solutions manual (available to instructors only)

The demand for more durable fasteners to extend the life of equipment such as fishing vessels makes this illustrated introduction to hot-dip galvanizing an invaluable addition to the bookshelves of works managers, engineers, government officials and field project officers. Hot-dip galvanizing is a cost-effective method of protecting cast iron or steel components from corrosion by coating them in zinc, thereby increasing the life of nuts, bolts and other items normally exposed to the elements. The first section of this book describes wet, dry and 'old dry' processes of hot-dip galvanizing, including health and safety, principles and benefits, equipment, materials, power supply, maintenance and quality control. The processes are illustrated with flow diagrams and there are tables to compare the relative benefits of the different options. The second section covers the specification and costing for a galvanizing plant once the market requirements have been established and the best method has been selected.

A series of concurrent pressures in the early 2000s-climate change, financial system crashes, economic development in rural regions, and shifts in geopolitics-intensified interest in alternative energy production. At the same time, rising oil prices rendered alternative fuels a more economically viable option. Among these energy sources, liquid biofuels (bioethanol and biodiesel) and natural gas derived from hydraulic fracturing ("fracking") took center stage as promising commodities and technologies. But controversy quickly erupted in surprisingly similar ways around both renewable fuels. Global enthusiasm for these fuels-and the widespread projections for their production around the world-collided with local politics in debates over "food versus fuel" and concerns over "land grabs." What seemed, from a global perspective, like empty lands ripe for development were, to rural communities, vibrant and already contested spaces. As proposals for biofuels and fracking landed in specific communities and ecosystems, they reignited and reshaped old disputes over land, water, and decision-making authority. Fueling Resistance offers an account of how and why controversies over these different fuels unfolded in surprisingly similar ways in the global North and South. To explain these convergent dynamics of contention and resistance, Kate J. Neville argues that the emergence of grievances and the patterns of resistance to new fuel technologies depends less on the type of energy developed (renewable versus fossil fuel) than on intersecting elements of the political economy of energy: finance, ownership, and trade relations. As local commodities enter global supply chains and are integrated into existing corporate structures, opportunities arise to broker connections between otherwise disparate communities. Neville looks at biofuels in Kenya and fracking in the Canadian Yukon and shows how organizers connect specific energy projects to broader issues of globalization, climate, food, water, and justice. Taken together, the intersecting elements of the political economy of energy shape the contentious politics of biofuels and fracking at both local and global scales, and help explain how and why particular mechanisms of contention emerge at different times and places.