This book covers the performance aspects of nanocomposite supercapacitor materials based on transition metal oxides, activated carbon, carbon nanotubes, carbon nanofibers, graphene and conducting polymers. It compares the performance of simple electrode materials versus binary and ternary composites, while highlighting the advantages and challenges of different supercapacitor electrode materials. This book is part of the Handbook of Nanocomposite Supercapacitor Materials. Supercapacitors have emerged as promising devices for electrochemical energy storage, playing an important role in energy harvesting for meeting the current demands of increasing global energy consumption. The handbook covers the materials science and engineering of nanocomposite supercapacitors, ranging from their general characteristics and performance to materials selection, design and construction. Covering both fundamentals and recent developments, this handbook serves a readership encompassing students, professionals and researchers throughout academia and industry, particularly in the fields of materials chemistry, electrochemistry, and energy storage and conversion. It is ideal as a reference work and primary resource for any introductory senior-level undergraduate or beginning graduate course covering supercapacitors.

This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact. Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals. However, the stable, bioactive substances excreted by patients have unfavorable effects on non-target species. To overcome these disadvantages of these highly stable, potent substances, drug design to turn off bioactivity after release into the environment is needed. The book describes the development of eco-friendly NK3R antagonists by introducing a labile functional moiety and substituting a scaffold. This resulted in a novel NK3R antagonist that oxidized into its inactive form when exposed to air. Further, the book presents an efficient and easily achievable synthetic method of creating triazolopiperazine scaffolds, as well as a structure-activity relationship study involving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist. Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with reduced environmental impact.

Basic Laboratory Methods for Biotechnology, Third Edition is a versatile textbook that provides students with a solid foundation to pursue employment in the biotech industry and can later serve as a practical reference to ensure success at each stage in their career. The authors focus on basic principles and methods while skillfully including recent innovations and industry trends throughout. Fundamental laboratory skills are emphasized, and boxed content provides step by step laboratory method instructions for ease of reference at any point in the students' progress. Worked through examples and practice problems and solutions assist student comprehension. Coverage includes safety practices and instructions on using common laboratory instruments. Key Features: Provides a valuable reference for laboratory professionals at all stages of their careers. Focuses on basic principles and methods to provide students with the knowledge needed to begin a career in the Biotechnology industry. Describes fundamental laboratory skills. Includes laboratory scenario-based questions that require students to write or discuss their answers to ensure they have mastered the chapter content. Updates reflect recent innovations and regulatory requirements to ensure students stay up to date. Tables, a detailed glossary, practice problems and solutions, case studies and anecdotes provide students with the tools needed to master the content. To succeed in the lab, it is crucial to be comfortable with the math calculations that are part of everyday work. This accessible introduction to common laboratory techniques focuses on the basics, helping even readers with good math skills to practice the most frequently encountered types of problems. Basic Laboratory Calculations for Biotechnology, Second Edition discusses very common laboratory problems, all applied to real situations. It explores multiple strategies for solving problems for a better understanding of the underlying math. Primarily organized around laboratory applications, the book begins with more general topics and moves into more specific biotechnology laboratory techniques at the end. This book features hundreds of practice problems, all with solutions and many with boxed, complete explanations; plus hundreds of "story problems" relating to real situations in the lab. Additional features include: Discusses common laboratory problems with all material applied to real situations Presents multiple strategies for solving problems help students to better understand the underlying math Provides hundreds of practice problems and their solutions Enables students to complete the material in a self-paced course structure with little teacher assistance Includes hundreds of "story problems"that relate to real situations encountered in the laboratory

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

This new book clarifies and quantifies many of the technical interactions in the process. It distinguishes itself from other books on the subject by being a seamless story of the advanced aspects of the rotational molding process. There are seven chapters within the book.

The U.S. market for rotational molding products was one billion pounds in the year 2000. The growth of the rotational molding industry has grown at 10 to 15% per year. With this growth has come an increasing need for details on the complex, technical aspects of the process.

Key Features:

-Clarifies and quantifies many of the technical interactions in the rotational molding process.

-Seamless story of the advanced aspects of the process.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion-based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production.

This volume reviews the drinking water treatments in which AOPs display a high application potential. Firstly it reveals the typical supply sources and limitations of conventional technologies and critically reviews natural organic matter characterization and removal techniques, focusing mainly on AOP treatments. It then explores using AOPs for simultaneous inactivation/disinfection of several types of microorganisms, including highly resistant Cryptosporidium protozoa. Lastly, it discusses relevant miscellaneous topics, like the most promising AOP solid catalysts, the regime change of Fenton-like processes toward continuous reactors, the application of chemometrics for process optimization, the impact on disinfection byproducts and the tracing of toxicity during AOP treatments. This work is a useful reference for researchers and students involved in water technologies, including analytical and environmental chemistry, chemical and environmental engineering, toxicology, biotechnology, and related fields. It is intended to encourage industrial and public-health scientists and decision-makers to accelerate the application of AOPs as technological alternatives for the improvement of drinking water treatment plants.

Wheat Quality for Improving Processing and Human Health brings together an international group of leading wheat scientists to outline highly relevant and diverse aspects and the latest advances in understanding of the world's most consumed cereal. Topics covered include LMW glutenins, starch-related proteins, and the impact of processing on composition and consumer health. Individual chapters focus on important factors such as FODMAPs, protein structure, dough viscoelasticity and fumonisins. The environmental effects on allergen content are comprehensively covered, as are phenolic compounds and molecular markers. The major quality screening tools and genetic resources are reviewed in depth. Gluten is a major focus of this work with chapters dedicated to health effects, analytical methods and standards, proteomics and mutant proteins. Starting in 2015, wheat quality scientists from across the globe have united to develop the Expert Working Group for Improving Wheat Quality for Processing and Health under the umbrella of the Wheat Initiative. This joint effort provides a framework to establish strategic research and organisation priorities for wheat research at the international level in both developed and developing countries. This Expert Working Group aims to maintain and improve wheat quality for processing and health under varying environmental conditions. The Group focuses on a broad range of wheat quality issues including seed proteins, carbohydrates, nutrition quality and micronutrient content, grain processing and food safety. Bioactive compounds are also considered, both those with negative effects such as allergens and mycotoxins, and those with positive effects such as antioxidants and fibre. The Group also works in the development of germplasm sets and other tools that promote wheat quality research. Wheat quality specialists working on the wheat value chain, and nutritionists will find this book a useful resource to increase and update their knowledge of wheat quality, nutrition and health issues.

This book focuses on the preparation and characterisation of polyvinyl alcohol (PVA)/ halloysite nanotube (HNT) bionanocomposite films with different HNT contents for potential use in food packaging. It examines the effect of material composition and nanofiller content on mechanical, thermal and optical properties in relation to their morphological structures, and also comprehensively describes the water resistance, biodegradation and migration rates of such bionanocomposites, as well as their barrier properties in terms of water vapour transmission, and water vapour, air and oxygen permeabilities. Further, this book discusses the use of Nielsen model and Cussler model to predict the relative permeability of bionanocomposites, demonstrating that Nielsen model is more effective and in better agreement with experimental data obtained. Lastly, it discusses the application of bionanocomposite films in food packaging to prolong the shelf life of freshly cut avocados and peaches.

This volume compiles and discusses the fundamental and multidisciplinary knowledge on adsorption and separation processes using zeolites as adsorbents. Over the last decade, a large amount of research has been carried out for the development of zeolites as adsorbents. However, there is still a growing interest to increase the understanding of such selective adsorbents. Therefore, synthesis strategies and new approaches for developing new selective zeolite adsorbents for gas separation are presented in the first chapter. In addition, a chapter focused on adsorption characterization techniques of microporous materials is included. This will be helpful for advanced readers, since the new IUPAC recommendations for microporous characterization are not still widely employed by the zeolite community. Experimental and theoretical aspects of economically and environmentally relevant separations, which have been successfully carried out with zeolites, are discussed in detail in subsequent chapters. Finally, industrial zeolite based adsorption and separation processes as well as current perspectives for new zeolite based separations, and improvements of current technologies are presented.

In Advanced ULSI interconnects - fundamentals and applications we bring a comprehensive description of copper-based interconnect technology for ultra-lar- scale integration (ULSI) technology for integrated circuit (IC) application. In- grated circuit technology is the base for all modern electronics systems. You can ?nd electronics systems today everywhere: from toys and home appliances to a- planes and space shuttles. Electronics systems form the hardware that together with software are the bases of the modern information society. The rapid growth and vast exploitation of modern electronics system create a strong demand for new and improved electronic circuits as demonstrated by the amazing progress in the ?eld of ULSI technology. This progress is well described by the famous "Moore's law" which states, in its most general form, that all the metrics that describe integrated circuit performance (e. g. , speed, number of devices, chip area) improve expon- tially as a function of time. For example, the number of components per chip d- bles every 18 months and the critical dimension on a chip has shrunk by 50% every 2 years on average in the last 30 years. This rapid growth in integrated circuits te- nology results in highly complex integrated circuits with an increasing number of interconnects on chips and between the chip and its package. The complexity of the interconnect network on chips involves an increasing number of metal lines per interconnect level, more interconnect levels, and at the same time a reduction in the interconnect line critical dimensions.

Food Safety Engineering is the first reference work to provide up-to-date coverage of the advanced technologies and strategies for the engineering of safe foods. Researchers, laboratory staff and food industry professionals with an interest in food engineering safety will find a singular source containing all of the needed information required to understand this rapidly advancing topic. The text lays a solid foundation for solving microbial food safety problems, developing advanced thermal and non-thermal technologies, designing food safety preventive control processes and sustainable operation of the food safety preventive control processes. The first section of chapters presents a comprehensive overview of food microbiology from foodborne pathogens to detection methods. The next section focuses on preventative practices, detailing all of the major manufacturing processes assuring the safety of foods including Good Manufacturing Practices (GMP), Hazard Analysis and Critical Control Points (HACCP), Hazard Analysis and Risk-Based Preventive Controls (HARPC), food traceability, and recalls. Further sections provide insights into plant layout and equipment design, and maintenance. Modeling and process design are covered in depth. Conventional and novel preventive controls for food safety include the current and emerging food processing technologies. Further sections focus on such important aspects as aseptic packaging and post-packaging technologies. With its comprehensive scope of up-to-date technologies and manufacturing processes, this is a useful and first-of-its kind text for the next generation food safety engineering professionals.

This book is based on selected papers from keynote and symposium sessions given at the 16th International Union of Food Science and Technology (IUFoST) World Congress, held in Foz do Iguacu, Brazil August, 2012. The theme of the Congress was the challenges faced by food science in both the developed and developing regions of the world. The symposia featured prominent world-renowned keynote and plenary speakers, young researchers, and the technical sessions covered the whole spectrum of basic and applied food science and technology, including consumer issues and education, diets and health, ethnic foods, and R&D.

The 20th Century World has been transformed by the discovery and use of plastics. Today plastic materials are used in a wide variety of applications, from building and construction to packaging, from sports equipment to transportation. The vast number of plastics materials discovered over the past 40 years and their wide range of properties make them uniquely suited to a very broad spectrum of applications.

This combination of the successful utilisation of the materials and the number of types of material available has led to the growth of an array of technical terms within the field. The "Dictionary" is intended as a reference tool for readers to negotiate these terms.

The main part of the "Technical Dictionary of Plastics Materials" presents a comprehensive set of extended definitions of technical terms relating to all facts of the materials aspect of plastics technology. The definitions cover the nature of plastics materials, their composition (including relevent non-polymeric componants and additives, such as stabilisers, fillers, colourants, etc), their properties (including methods of property determination, testing, and evaluation), their applications, and their handling and behaviour in processing. In many cases reference is given to the relevant technical standards from the International (ISO), British (BSI), and American (ASTM) standards.

In addition to the main part of the "Dictionary" containing the definitions there are two further sections. The first gives explanations of the abbreviated terms (letter symbols) used for the parent polymer and for the other constituents of plastics materials, while the second identifies the trade names of a number of plastics materials and their components.

This book provides an overview of polyolefine production, including several recent breakthrough innovations in the fields of catalysis, process technology, and materials design. The industrial development of polymers is an extraordinary example of multidisciplinary cooperation, involving experts from different fields. An understanding of structure-property and processing relationships leads to the design of materials with innovative performance profiles. A comprehensive description of the connection between innovative material performance and multimodal polymer design, which incorporates both flexibility and constraints of multimodal processes and catalyst needs, is provided. This book provides a summary of the polymerization process, from the atomistic level to the macroscale, process components, including catalysts, and their influence on final polymer performance. This reference merges academic research and industrial knowledge to fill the gaps between academic research and industrial processes. * Connects innovative material performance to the flexibility of multimodal polymer design processes; * Provides a comprehensive description of the polymerization process from the atomic level to the macroscale; * Presents a polyhedric view of multimodal polymer production, including structure, property, and processing relationships, and the development of new materials.

The "greening" of industry processes - i.e., making them more sustainable - is a popular and often lucrative trend which has seen increased attention in recent years. Green Chemical Processes, the 2nd volume of Green Chemical Processing, covers the hot topic of sustainability in chemistry with a view to education, as well as considering corporate and environmental interests, e.g. in the context of energy production. The diverse team of authors allows for a balance between these different, but interconnected perspectives. The American Chemical Society's 12 Principles of Green Chemistry are woven throughout this text as well as the series to which this book belongs.

This book investigates in detail the concepts and principles of green chemistry and related methodologies, including green synthesis, green activation methods, green catalysis, green solvents, and green design to achieve process intensification while at the same time ensuring process safety and promoting ecological civilization and environmental protection. Moreover, it incorporates elements of chemical management and chemical education, highlighting chemists' responsibility to protect humankind and foster green and sustainable development in chemistry. Combining Chinese and Belarus wisdom, this book is intended for those working in the chemical industry who are interested in environmental protection and sustainable development, as well as undergraduate and graduate students who are interested in green chemistry and related technologies.

This book describes practices used on farms and in farmers markets selling foods directly to consumers in U.S. and international markets. It identifies hazards associated with those practices that could put consumers at increased risk for foodborne illness. It also provides tools for identifying hazards on farms and in markets and guidance for establishing food-safe markets. The local food movement, inspired by initiatives such as the USDA's "Know Your Farmer, Know Your Food"; "Farm to School"; "Farm to Pre-school"; and "The People's Garden", is sweeping the country. Nowhere is this interest more evident than at farmers markets. The number of farmers markets has increased almost 400% since the early 1990s, with over 8,600 farmers markets listed in the USDA's market directory in 2016. Many of the customers for local markets are senior adults, people who may have health concerns, and mothers with young children shopping for foods they perceive to be healthier and safer than those available in grocery stores. This means that many of the customers may be in population groups that are most at risk for foodborne illness and the serious complications that can result. In surveys, however, farmers selling directly to consumers self-reported practices that could increase risk for foodborne illnesses. These included use of raw manure as fertilizer without appropriate waiting periods between application and harvest, as outlined in the National Organic Program, a lack of sanitation training for farm workers handling produce, a lack of proper cleaning and sanitizing of surfaces that come in contact with produce, and use of untested surface water for rinsing produce before taking it to market. Surveys of market managers found that many had limited experience and most had no food safety plans for their markets. Observational studies in markets have corroborated self-reported practices that could increase foodborne illness risks, including lack of handwashing, lack of access to well-maintained toilet and handwashing facilities, use of materials that cannot be cleaned and sanitized appropriately, and lack of temperature control for foods that must have time and temperature controlled for safety. These potential food safety risks are not only seen in U.S. farmers markets, but also have been identified in international markets. This book is unique in that it provides evidence-based information about food safety hazards and potential risks associated with farmers markets. It presents an overview of farm and market practices and offers guidance for enhancing food safety on farms and in markets for educators, farmers, producers, vendors and market managers. Dr. Judy A. Harrison is a Professor in the Department of Foods and Nutrition at the University of Georgia (UGA) where she has been named a Walter Bernard Hill Fellow for distinguished achievement in public service and outreach. Serving as a food safety specialist for UGA Cooperative Extension, she has provided 25 years of food safety education for a variety of audiences across the food system.

This book aims to address the major aspects of future drug product development and therapy for older adults, giving practical guidance for the rational product and clinical development and prescribing of drug products to this ever growing segment of the population. With authors coming from key "aging" markets such as Europe, the USA, China and Japan, the book will provide valuable information for students, scientists, regulators, practitioners, and other healthcare professionals from academia, industry and regulatory bodies.