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Demonstrates how substitution of a variety of ligands can render
albumin a versatile targeting tool for selective drug accumulation
in various cell populations of the liver
The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. This part focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.
The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.
The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.
Despite food being safer, more affordable and more available than at any time in human history, consumers are increasingly skeptical and critical of today's food system. In Size Matters, Charlie Arnot provides thought provoking insight into how the food system lost consumer trust, what can be done to restore it, and the remarkable changes taking place on farms and in food companies, supermarkets and restaurants every day as technology and consumer demand drive radical change. The very systems and technologies that are mistrusted by consumers are driving a revolution that empowers individual consumers to find the perfect recipe of taste and nutrition to meet their specific needs and desires. Size Matters pulls back the curtain to examine the irony, competing priorities and new realities that shape today's food system.
This volume documents developments in the study of catalysis relating to organic synthesis and its application in industrial processes. It surveys a wide range of homo- and heterogeneous catalysis for industrial and pharmaceutical chemicals. It covers enantioselective hydrogenation, catalyzed hydrogens and oxidation, carbonylation, hydroaminomethylation, and more.
In recent years, the colours industry has undergone significant
change, as a result of increasing consumer demand for natural,
rather than synthetic food colours. The Food Colours Handbook
details some of these changes within a concise, easy-to-use
framework. With all chapters contributed by industry experts, the
book contains reviews of synthetic, nature-identical, and natural
Training in food processing can open up opportunities for individuals who lack business experience, by providing training in costing and marketing a new product. This book offers a blueprint for such comprehensive training.It first explains the importance of needs assessment, course preparation, monitoring and follow up, and the value of practical work and opportunities for trainees to discuss their ideas and discoveries. There are then ten case studies describing successful courses in three continents, and showing how the theory is put into practice and adapted to particular circumstances.With examples of forms and lesson plans, photographs of appropriate training environments, and details of institutions that support food-processing training, there is a wealth of information for trainers and organizers of courses throughout the world.
This book takes the reader on a journey from the moment that raw wood material enters the factory to the final pellet consumption. It starts by reviewing biomass application and its role for the future development of renewable energies, discussing different biomass conversion methods as alternatives to direct utilization. The second chapter then comprehensively examines densification processes, with a focus on the pelleting process. Chapter three further elaborates on the pelleting process, including an overview of the pellet structure and properties, and the history of this process. The subsequent chapters provide a detailed account of the production process from raw material delivery to final distribution, addressing the chemical and physical quality, and presenting measurement methods and standards. In the final chapters, the authors describe in detail the pellet combustion process and emissions.
This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance. It highlights the pharmacological potential of marine microbes and endophytic fungi and their bioactive secondary metabolites. Emphasis is also given on the significance of probiotics and their specialized molecules in human health and disease as well as their role in dietary intervention for reducing the risk of non-alcoholic fatty liver disease. This work also serves as excellent reference material for researchers, students and academicians in the field of natural product chemistry, pharmacology and applied microbiology.
This book examines and systematises knowledge concerning porous glass materials. Different volumes of pores and the methods of directly synthesising the glass with predefined sizes are discussed as well. Likewise, the primary approaches on determining parameters of porous structures are a topic of interest within this text. A separate chapter is devoted to properties of porous glass; these include optical, electrical, sensor and transport of it and its materials. Authors provide practical recommendations based on their experience with synthesis as well as handling and applying this specific glass.
Updated throughout to reflect advances over the last decade, the Fifth Edition continues the handbook's tradition of authoritative coverage of fundamentals, production methods, properties, and applications of plastics and polymer-based materials. It covers tooling for plastics fabrication processes, thermoplastics, thermosetting plastics, foamed plastics, reinforced plastics, plastisols, and new developments in mold design. It also discusses rubber compounding and processing technologies. More recent developments in polymer fabrication and processing, including electrospinning, electrografted coating, polymer-metal hybrid joining, flex printing, and rapid prototyping/ 3D printing, are also presented. The handbook highlights advanced materials including natural and synthetic gfnanosize polymers, their unusual properties, and innovative applications, as well as polymer-carbon nanocomposites, graphene-based polymer nanocomposites, smart healable polymer composites, smart polymer coatings, electroactive polymers, polymer nanomaterials, and novel nano-/microfibrillar polymer composites. It offers updates on polymer solar battery development, plastics recycling and disposal methods, new concepts of "upcycling" and single-polymer composites, renewable synthetic polymers, biodegradable plastics and composites, and toxicity of plastics. The book also provides an overview of new developments in polymer applications in various fields including packaging, building and construction, corrosion prevention and control, automotive, aerospace applications, electrical and electronic applications, agriculture and horticulture, domestic appliances and business machines, medical and biomedical applications, marine and offshore applications, and sports.
Offering a detailed, step-by-step guide to building a compliant cleaning validation program, Cleaning Validation: A Practical Approach covers trends in control, procedures, cleaning agents and tools, sampling techniques, analytical methods, and regulatory issues. The author provides practical examples, database formats, standard operating procedures, work instructions, protocols, and reports. He gives readers the tools they need to develop an effective and manageable program that will not only be acceptable to both US and non-US regulatory authorities but will conserve an organization's time, money, and people resources.
Now in its fifth edition, Food Science remains the most popular and reliable text for introductory courses in food science and technology. This new edition retains the basic format and pedagogical features of previous editions and provides an up-to-date foundation upon which more advanced and specialized knowledge can be built. This essential volume introduces and surveys the broad and complex interrelationships among food ingredients, processing, packaging, distribution and storage, and explores how these factors influence food quality and safety. Reflecting recent advances and emerging technologies in the area, this new edition includes updated commodity and ingredient chapters to emphasize the growing importance of analogs, macro-substitutions, fat fiber and sugar substitutes and replacement products, especially as they affect new product development and increasing concerns for a healthier diet. Revised processing chapters include changing attitudes toward food irradiation, greater use of microwave cooking and microwaveable products, controlled and modified atmosphere packaging and expanding technologies such a extrusion cooking, ohmic heating and supercritical fluid extraction, new information that addresses concerns about the responsible management of food technology, considering environmental, social and economic consequences, as well as the increasing globalization of the food industry. Discussions of food safety an consumer protection including newer phychrotropic pathogens; HAACP techniques for product safety and quality; new information on food additives; pesticides and hormones; and the latest information on nutrition labeling and food regulation. An outstanding text for students with little or no previous instruction in food science and technology, Food Science is also a valuable reference for professionals in food processing, as well as for those working in fields that service, regulate or otherwise interface with the food industry.
This book is the first volume of two volumes on cyclodextrins published in the series Environmental Chemistry for a Sustainable World. After a brief description of the cyclodextrin fundamentals, the first chapter by Gregorio Crini et al. provides an overview of cyclodextrin research during the last 5 years. The second chapter by Michal Rezanka discusses the synthesis of novel cyclodextrin systems by selective modifications. Then Eric Monflier et al. describes the synthesis of nanostructured porous materials based on cyclodextrins, and applications in heterogeneous catalysis and photocatalysis. The use of thermal analyses for assessing cyclodextrin inclusion complexes is reviewed in chapter 4 by Daniel Hadaruga et al. Experimental methods for measuring binding constants of cyclodextrin inclusion compounds are presented by David Landy. The second volume reviews cyclodextrin applications in medicine, food, environment and liquid crystals.
This book gives a comprehensive explanation of what governs the breakage of extruded materials, and what techniques are used to measure it. The breakage during impact aka collision is explained using basic laws of nature allowing readers to determine the handling severity of catalyst manufacturing equipment and the severity of entire plants. This information can then be used to improve on the architecture of existing plants and how to design grass-roots plants. The book begins with a summary of particle forming techniques in the particle technology industry. It covers extrusion technology in more detail since extrusion is one of the workhorses for particle manufacture. A section is also dedicated on how to describe transport and chemical reaction in such particulates for of course their final use. It presents the fundamentals of the study of breakage by relating basic laws in different fields (mechanics and physics) and this leads to two novel dimensionless groups that govern breakage. These topics are then apply these topics to R&D scale-up and manufacturing and shows how this approach is directly applicable.
A one-stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target-oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry. For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.
Suppliers of pharmaceutical manufacturing equipment must ensure that their equipment is provided to their customers in a validatable state. Written in simple, clear, and concise language that gets past all the regulationese, this book covers the basics of validation, planning process equipment design and construction, documentation requirements, avoiding validation pitfalls, and the types of services the supplier should provide. The book provides insights on how to avoid the costly and time-consuming problem of reworking the equipment to develop the information that is needed to successfully complete their validation package - after the equipment has been delivered and installed. Here in one volume is all the information suppliers and manufacturers need to be able to effectively conduct business in a cost- and time-effective manner. Key areas of discussion include: o Validation and GMP issues o Why validation is so important to pharmaceutical manufacturers o The role of equipment suppliers in supporting validation o How validation affects the quality of drugs o A discussion of the importance of each phase of validation o Examples of pre-validation work o Pharmaceutical industry conventions for equipment design & construction o Questions to ask about validation, including a checklist o Regulations in plain language, including the terms and vocabulary o Computer validation o Business & cost issues
The first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. The second contribution provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses. And the third contribution discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.
Finding consistent, analytical discussions of processes and principles of lyophilization can be challenging and often frustrating. The first resource to gather information about the field, Lyophilization: Introduction and Basic Principles is still the book to have on lyophilization. Presenting information in an easy-to-read style, the book comprehensively and authoritatively covers the field. Using plain, unpretentious language, author Thomas A. Jennings pulls together information from diverse sources to provide an authoritative compendium of the lyophilization process and its basic principles. He provides important discussions about the nature of the container-closure system and the equipment, tools, and environments required. Case studies and examples of solutions illustrate the many ways problems can be addressed in the lyophilization process. The book covers: -Properties of lyophilized materials -Product formulation requirements and the thermal properties of formulations -Importance of process water -Phase changes -Thermal analytical methods -Freezing, primary, and secondary drying processes -Effect of vacuum freeze-dryers, both now and in the future Including over 150 illustrations, global symbols, and more than 350 references, this book is the complete guide to lyophilization, its analytical methods, measurement of process parameters, and equipment.
Polymer photonics is an interdisciplinary field which demands excellence both in optics (photonics) and materials science (polymer). However, theses disciplines have developed independently, and therefore the demand for a comprehensive work featuring the fundamentals of photonic polymers is greater than ever. This volume focuses on Polymer Optical Fiber and their applications. The first part of the book introduces typical optical fibers according to their classifications of material, propagating mode, and structure. Optical properties, the high bandwidth POF and transmission loss are discussed, followed by an outline on the propagating mode characteristics and how they affect the performances of the fiber. The second part of the book reviews conventional materials of POFs and gives an overview on fabrication methods. This is followed by a survey of characterization methods. Based on the characteristics of optical communication systems, the last chapter will concentrate on the many advantages of POF in link and network design. Written by a top expert in the field, this is an invaluable resource for semiconductor physicists, materials scientists, polymer chemists, electrical engineers, and those working in the semiconductor industry.
Nanoscale pattern transfer technology using molds is a rapidly advancing area and one that has seen much recent attention due to its potential for use in nanotechnology industries and applications. However, because of these rapid advances, it can be difficult to keep up with the technological trends and the latest cutting-edge methods. In order to fully understand these pioneering technologies, a comprehensive understanding of the basic science and an overview of the techniques are required. Nanoimprint Technology: Nanotransfer for Thermoplastic and Photocurable Polymers covers the latest nanotransfer science based on polymer behaviour. Polymer fluid dynamics are described in detail, and injection moulding, nanoimprint lithography and micro contact printing are also discussed. Cutting-edge nanotransfer technologies and applications are also considered and future trends in industry are examined. Key features: Covers the fundamentals of nanoimprint technology Presents cutting-edge techniques and applications Provides industrial examples and describes the mold fabrication process Considers nanotransfer of thermoplastics by simulation Describes the design and evaluation of UV curable polymer Nanoimprint Technology: Nanotransfer for Thermoplastic and Photocurable Polymers is a comprehensive reference for industry engineers as well as graduate and undergraduate students, and is a useful source of information for anyone looking to improve their understanding of nanotransfer mechanisms and methods.
Ein professioneller Leitfaden zu 3D- und 4D-Drucktechniken in der Biomedizin und Pharmazie. 3D and 4D Printing in Biomedical Applications f hrt fundiert in 3D- und 4D-Drucktechniken in der Biomedizin und Pharmazie ein. Dieses Fachbuch enth lt Beitr ge von internationalen Wissenschaftlern und Industrieexperten und bietet einen berblick ber das Thema, aktuelle Forschungsergebnisse und Innovationen zu Anwendungen in der Pharmazie und Biomedizin. Untersucht werden Prozessoptimierung, Innovationsprozesse, Engineering- und Plattformtechnologien. Dar ber hinaus informiert das Werk ber Entwicklungen in der Biomedizin, u. a. ber Formged chtnispolymere, Biofabrikation in 4D und Knochen aus dem Drucker. Eine F lle von Themen werden behandelt und n her beleuchtet: Potenzial des 3D-Drucks f r die Wirkstoffverabreichung, neue Fertigungsprozess, Bio-Scaffolding, neueste Trends und Herausforderungen f r 3D- und 4D-Bioprinting in der Biofabrikation. Dieses wertvolle Referenzwerk - ist ein umfassender Leitfaden zu 3D- und 4D-Drucktechniken in der Biomedizin und Pharmazie. - informiert u. a. ber die erste 3D-Druckplattform mit FDA-Zulassung f r ein pharmazeutisches Erzeugnis. - enth lt Reviews der derzeit verf gbaren pharmazeutischen Erzeugnisse, die per 3D-Druck hergestellt wurden. - pr sentiert die j ngsten Fortschritte bei neuartigen Materialien f r den 3D- und 4D-Druck und biomedizinische Anwendungen.
This book explains the aspiring vision of a sustainable hydrogen generating system which employs nanotechnology one way or the other and presents a detailed update on research activities, achievements and challenges. It explores how nanotechnology is reshaping science in general and how this can be applied to the generation and storage of hydrogen energy. This book begins by highlighting the importance of hydrogen a source of sustainable energy and its impact on the technical advances of fuel cells, internal combustion engines, batteries and power plants. The book depicts the role of nanotechnology in the development of sustainable hydrogen. Comprehensive studies on various nanotechnologies involved in hydrogen generation are discussed in separate chapters, representing a complete picture of hydrogen generation utilizing nanotechnology. This book serves as a useful research tool for academics and practitioners looking towards new ways to develop and consume energy, without conceding our environment. Providing the advantages and disadvantages of each technology discussed, this book shows the benefits of utilizing nanotechnology in this field.
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