This book provides an overview of polyolefine production, including several recent breakthrough innovations in the fields of catalysis, process technology, and materials design. The industrial development of polymers is an extraordinary example of multidisciplinary cooperation, involving experts from different fields. An understanding of structure-property and processing relationships leads to the design of materials with innovative performance profiles. A comprehensive description of the connection between innovative material performance and multimodal polymer design, which incorporates both flexibility and constraints of multimodal processes and catalyst needs, is provided. This book provides a summary of the polymerization process, from the atomistic level to the macroscale, process components, including catalysts, and their influence on final polymer performance. This reference merges academic research and industrial knowledge to fill the gaps between academic research and industrial processes. * Connects innovative material performance to the flexibility of multimodal polymer design processes; * Provides a comprehensive description of the polymerization process from the atomic level to the macroscale; * Presents a polyhedric view of multimodal polymer production, including structure, property, and processing relationships, and the development of new materials.

This contributed volume presents an overview of concepts, methods, and applications used in several quantitative areas of drug research, development, and marketing. Chapters bring together the theories and applications of various disciplines, allowing readers to learn more about quantitative fields, and to better recognize the differences between them. Because it provides a thorough overview, this will serve as a self-contained resource for readers interested in the pharmaceutical industry, and the quantitative methods that serve as its foundation. Specific disciplines covered include: Biostatistics Pharmacometrics Genomics Bioinformatics Pharmacoepidemiology Commercial analytics Operational analytics Quantitative Methods in Pharmaceutical Research and Development is ideal for undergraduate students interested in learning about real-world applications of quantitative methods, and the potential career options open to them. It will also be of interest to experts working in these areas.

This volume reviews the drinking water treatments in which AOPs display a high application potential. Firstly it reveals the typical supply sources and limitations of conventional technologies and critically reviews natural organic matter characterization and removal techniques, focusing mainly on AOP treatments. It then explores using AOPs for simultaneous inactivation/disinfection of several types of microorganisms, including highly resistant Cryptosporidium protozoa. Lastly, it discusses relevant miscellaneous topics, like the most promising AOP solid catalysts, the regime change of Fenton-like processes toward continuous reactors, the application of chemometrics for process optimization, the impact on disinfection byproducts and the tracing of toxicity during AOP treatments. This work is a useful reference for researchers and students involved in water technologies, including analytical and environmental chemistry, chemical and environmental engineering, toxicology, biotechnology, and related fields. It is intended to encourage industrial and public-health scientists and decision-makers to accelerate the application of AOPs as technological alternatives for the improvement of drinking water treatment plants.

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

This book presents the select proceedings of the International Conference on Functional Material, Manufacturing and Performances (ICFMMP) 2019. The book provides the state-of-the-art research, development, and commercial prospective of recent advances in materials science and engineering. The contents cover various synthesis and fabrication routes of functional and smart materials for applications in mechanical engineering, manufacturing, metrology, nanotechnology, physics, chemical and biological sciences, civil engineering, food science among others. It also provides the evolutionary behavior of materials science for industrial applications. This book will be a useful resource for researchers as well as professionals interested in the highly interdisciplinary field of materials science.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

This is a completely revised edition, including new material, from 'Culture Media for Food Microbiology' by J.E.L. Corry et al., published in Progress in Industrial Microbiology, Volume 34, Second Impression 1999.

Written by the Working Party on Culture Media, of the International Committee on Food Microbiology and Hygiene, this is a handy reference for microbiologists wanting to know which media to use for the detection of various groups of microbes in food, and how to check their performance.

The first part comprises reviews, written by international experts, of the media designed to isolate the major groups of microbes important in food spoilage, food fermentations or food-borne disease. The history and rationale of the selective agents, and the indicator systems are considered, as well as the relative merits of the various media. The second part contains monographs on approximately 90 of the most useful media.

The first edition of this book has been frequently quoted in standard methods, especially those published by the International Standards Organisation (ISO) and the European Standards Organisation (CEN), as well as in the manuals of companies manufacturing microbiological media. In this second edition, almost all of the reviews have been completely rewritten, and the remainder revised. Approximately twelve monographs have been added and a few deleted. This book will be useful to anyone working in laboratories examining food - industrial, contract, medical, academic or public analyst, as well as other microbiologists, working in the pharmaceutical, cosmetic and clinical (medical and veterinary) areas - particularly with respect to quality assurance of media and methods in relation to laboratory accreditation.

This book is based on selected papers from keynote and symposium sessions given at the 16th International Union of Food Science and Technology (IUFoST) World Congress, held in Foz do Iguacu, Brazil August, 2012. The theme of the Congress was the challenges faced by food science in both the developed and developing regions of the world. The symposia featured prominent world-renowned keynote and plenary speakers, young researchers, and the technical sessions covered the whole spectrum of basic and applied food science and technology, including consumer issues and education, diets and health, ethnic foods, and R&D.

High-pressure Molecular Spectroscopy describes examples of the applications of several spectroscopic methods to investigate the behavior of various chemical systems under high pressures, including guest-host interactions, chemical reactions, molecule-based multiferroics, lanthanide ion-doped glasses, and organic, inorganic and organometallic materials. The techniques involved include: Luminescence studies Inelastic neutron scattering Infrared and Raman studies Synchrotron X-ray diffraction

The book presents a collection of chapters on the current problems associated with hydrogen damage. It discusses the effect of hydrogen on material properties and its interaction with the material microstructure, physical features of hydrogen transport in metals and alloys, as well as applicable methods of measuring concentration of hydrogen in solid media.

This book details zeolites, their structures and the parameters that influence their synthesis, providing a new and actual perspective of this field. Following this, the authors show different processes used to synthesize zeolites using residues, natural materials, and other eco-friendly materials such as raw powder glass, clays, aluminum cans, diatomites, rice ashes or coal ashes. Finally, this book gives the reader a wide range of different synthesis methods that they can be applied to several industrial processes.

Plasticizer Databook contains data on selection of the most important plasticizers in use today. The selection includes 375 generic and commercial plasticizers. The generic plasticizers contain data for particular chemical compound from numerous sources and these generic plasticizer tables usually contain the most extensive information. The commercial plasticizers include only data given by plasticizer manufacturers. This allows comparison of properties of commercial plasticizers coming from different sources.

The databook was developed to contain data required in plasticizers application. Attempts have been made to include plasticizers used in various sectors of industry to provide information for all users and to help in finding new solutions. Plasticizers included in the book differ from solvents by boiling point, which is above 250oC, but some plasticizers are used as temporary plasticizers or are expected to react with other components of mixture. These substances will not meet the boiling temperature criterion but will still be included since they play role of plasticizers.
Based on the biggest plasticizer database ever published.

Includes 375 generic and commercial plasticizers.

Divided into sections for ease of use.

Cellulose nanocrystals are being used more frequently as processing and nanofabrication techniques have advanced considerably. Cellulose Nanocrystals includes topics including Extraction and Fabrication Methodologies, Scale-Up Strategies and Life Cycle Assessment, Surface Modification Strategies, Nanocomposites, and Characterization and Testing Protocols. This book will appeal to physical, chemical and biological scientists as well as engineers.

This book describes preparation techniques for well-defined, customizable poly(organo)phosphazene materials and their applications in nanomedicine, i.e. as macromolecular carriers for drug delivery, immunology, gene therapy, or tissue regeneration. This 2nd edition of Polyphosphazenes for Medical Applications has been updated and extended for researchers in the field as well as those considering using polyphosphazenes for a specific application.

This book describes practices used on farms and in farmers markets selling foods directly to consumers in U.S. and international markets. It identifies hazards associated with those practices that could put consumers at increased risk for foodborne illness. It also provides tools for identifying hazards on farms and in markets and guidance for establishing food-safe markets. The local food movement, inspired by initiatives such as the USDA's "Know Your Farmer, Know Your Food"; "Farm to School"; "Farm to Pre-school"; and "The People's Garden", is sweeping the country. Nowhere is this interest more evident than at farmers markets. The number of farmers markets has increased almost 400% since the early 1990s, with over 8,600 farmers markets listed in the USDA's market directory in 2016. Many of the customers for local markets are senior adults, people who may have health concerns, and mothers with young children shopping for foods they perceive to be healthier and safer than those available in grocery stores. This means that many of the customers may be in population groups that are most at risk for foodborne illness and the serious complications that can result. In surveys, however, farmers selling directly to consumers self-reported practices that could increase risk for foodborne illnesses. These included use of raw manure as fertilizer without appropriate waiting periods between application and harvest, as outlined in the National Organic Program, a lack of sanitation training for farm workers handling produce, a lack of proper cleaning and sanitizing of surfaces that come in contact with produce, and use of untested surface water for rinsing produce before taking it to market. Surveys of market managers found that many had limited experience and most had no food safety plans for their markets. Observational studies in markets have corroborated self-reported practices that could increase foodborne illness risks, including lack of handwashing, lack of access to well-maintained toilet and handwashing facilities, use of materials that cannot be cleaned and sanitized appropriately, and lack of temperature control for foods that must have time and temperature controlled for safety. These potential food safety risks are not only seen in U.S. farmers markets, but also have been identified in international markets. This book is unique in that it provides evidence-based information about food safety hazards and potential risks associated with farmers markets. It presents an overview of farm and market practices and offers guidance for enhancing food safety on farms and in markets for educators, farmers, producers, vendors and market managers. Dr. Judy A. Harrison is a Professor in the Department of Foods and Nutrition at the University of Georgia (UGA) where she has been named a Walter Bernard Hill Fellow for distinguished achievement in public service and outreach. Serving as a food safety specialist for UGA Cooperative Extension, she has provided 25 years of food safety education for a variety of audiences across the food system.

High Temperature Mechanical Behavior of Ceramic Composites provides an up-to-date comprehensive coverage of the mechanical behavior of ceramic matrix composites at elevated temperatures. Topics include both short-term behavior (strength, fracture toughness and R-curve behavior) and long-term behavior (creep, creep-fatigue, delayed failure and lifetime). Emphasis is on a review of fundamentals and on the mechanics and mechanisms underlying properties.
This is the first time that complete information of elevated temperature behavior of ceramic composites has ever been compacted together in a single volume. Of particular importance is that each chapter, written by internationally recognized experts, includes a substantial review component enabling the new material to be put in proper perspective.
Shanti Nair is Associate Professor at the Department of Mechanical Engineering at the University of Massachusetts at Amherst. Karl Jakus is Professor at the University of Massachusetts at Amherst.

Fruits of the Brazilian Cerrado: Composition and Functional Benefits describes the nutritional, chemical and physical characteristics of the fruits of the Cerrado, as well as their pharmacological effects and use in phytotherapics. Chapters are dedicated to the morphological characteristics, macronutrients, micronutrients and active compounds of various fruits, with separate sections covering their peels, leaves, nuts, pulps, and other components. The text also includes detailed studies on the treatment of diseases with these natural products, as well as their applications in popular use by local communities. Authors explain the importance of bioactive compounds found in the fruits and their possible mechanisms of action in the organism. This text thus provides a valuable reference to researchers studying a range of topics, including functional foods, phytotherapy, and plant science.

This book systematically analyses state-of-the-art technology and research related to desiccant dehumidification. It provides key insights into the current research direction, and presents global research and development interests. It begins by offering a comprehensive review of conventional desiccants and their underlying engineering challenges. Fundamental material characteristic properties and factors critical to the desiccant synthesis are highlighted. The applicability of next-generation advanced materials to address the challenges is documented, and the advantages of desiccant coated heat exchangers are evaluated. Lastly, the potential applications of desiccant dehumidifiers in various energy-connected applications are discussed, and case studies on industrial/building cooling systems are provided. Specifically targeted at HVAC engineers, thermal scientists, energy-engineering researchers, and graduate-level students in the field, the technical content balances fundamental concepts and applications.

The "greening" of industry processes - i.e., making them more sustainable - is a popular and often lucrative trend which has seen increased attention in recent years. Green Chemical Processes, the 2nd volume of Green Chemical Processing, covers the hot topic of sustainability in chemistry with a view to education, as well as considering corporate and environmental interests, e.g. in the context of energy production. The diverse team of authors allows for a balance between these different, but interconnected perspectives. The American Chemical Society's 12 Principles of Green Chemistry are woven throughout this text as well as the series to which this book belongs.

In this first book on an additive group of growing importance, the authors review the commercial additives available on the market. The applications chapters provide you with a step by step description of techniques to select and incorporate these additives in various products.

Engineers and scientits involved in polymer processing need practical information about these additives, their applications, and proper and safe handling. Until now much of this information has been difficult to obtain because of commercial secrecy.

In recent years, the applications of fluoropolymer additives have expanded significantly, with even the meaning of fluoropolymer additives expanding from relatively the narrow definition of PTFE powder fillers to a wide variety of fluoropolymer elastomers, used as a processing aid for plastics processing such as extrusion, injection molding, and film blowing. The benefits of fluoropolymer additives used in plastics are the elimination of sharkskin defects, increases in process speed and output (up to 20%), the reduction of die build up, the reduction of gels and optical defects, etc.

In addition, fluropolymer additives are being increasingly used in inks, lubricants, and coatings. For example, in the coating industry fluoropolymer additives can increase the life cycle of exterior coatings due to their excellent weatherability and subsequently increase the time between recoats.

Fluoropolymer additives are becoming more widely used with key applications including

use as a polymer processing aid (increasing speed and reducing faults) and as an additive

to lubricants, inks and coatings. This book is the only practical guide available to the

selection and use of fluoropolymer additives, and will help readers to optimize existing

fluoropolymer applications and implement new ones.

Fluoropolymers are known as an area where detailed information is hard to come by. In

this book two former DuPont employees provide a wide range of industry sectors with the

essential practical information and data they need to realize the full benefits of

fluoropolymer additives.

Written for practicing engineers, Ebnesajjad and Morgan take a highly practical approach

to the subject, based on real-world experience and case studies."