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Completey revised and updated, this second edition requires three volumes to accommodate the many changes in the science and technology associated with these products. Volume 1 covers formulation and product development, with chapters on the dosage form and its historical development. Volume 2 discusses the principles, characteristics, and operations of the processing functions of sterile drug products. Volume 3 offers comprehensive coverage of medical devices, quality assurance, and regulatory issues and explains current FDA enforcement activities, the voluntary compliance policy, select court cases, and how these relate to parenterals.
Is the future of food looking bleak - or better than ever? At a time when every day brings news of drought and famine, Amanda Little investigates what it will take to feed a hotter, hungrier, more crowded world. She explores the past along with the present and discovers startling innovations: remote-control crops, vertical farms, robot weedkillers, lab-grown meat, 3D-printed meals, water networks run by supercomputers, cloud seeding and sensors that monitor the microclimate of individual plants. She meets the creative and controversial minds changing the face of modern food production, and tackles fears over genetic modification with hard facts. The Fate of Food is a fascinating look at the threats and opportunities that lie ahead as we struggle for food security. Faced with a perilous future, it gives us reason to hope.
An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra
All medicinal products have to be licensed before marketing in any of the EEC, Nordic and EFTA countries. This book provides a systematic account of the major technical, administrative and legal requirements for registering a product in any of the national markets within the EEC, using the existing procedures, with guidance as to how these procedures are likely to change with the creation of a single European market in pharmaceuticals after 1992. The book should be of value to the pharmaceutical industry and their suppliers (the bulk excipient and active substance manufacturers); to government regulatory agencies; and to members of many technical, professional, scientific, medical and regulatory societies and organizations concerned directly and indirectly with medicinal products - particularly to members of the pharmaceutical and medical professions. There is an enormous interest in this subject in the EEC, the USA and Japan due to the likelihood of the creation in 1992 of a single market with some 350,000 patients.
Eating is a multisensory experience, yet chefs and scientists have only recently begun to deconstruct food's components, setting the stage for science-based cooking. In this global collaboration of essays, chefs and scientists advance culinary knowledge by testing hypotheses rooted in the physical and chemical properties of food. Using traditional and cutting-edge tools, ingredients, and techniques, these pioneers create, and sometimes revamp, dishes that respond to specific desires and serve up an original encounter with gastronomic practice. From the seemingly mundane to the food fantastic-from grilled cheese sandwiches, pizzas, and soft-boiled eggs to Turkish ice cream, sugar glasses, and jellified beads-the essays in The Kitchen as Laboratory cover a range of creations and their history and culture. They consider the significance of an eater's background and dining atmosphere and the importance of a chef's methods, as well as the strategies used to create a great diversity of foods and dishes. This collection will delight experts and amateurs alike, especially as restaurants rely more on science-based cooking and recreational cooks increasingly explore the physics and chemistry behind their art. Contributors end each essay with their personal thoughts on food, cooking, and science, offering rare insight into a professional's passion for playing with food.
This book presents the modern applications of hyphenated techniques in the analysis and study of the chemistry of grape, wine, and grape-derivative products. It explains the different applications and techniques used in the laboratory, such as liquid- and gas-phase chromatography, mass spectrometry, and capillary electrophoresis, and describes the methods developed using instrumentation with high performance and reliability. Additionally, the book covers the principal applications of modern sample preparation methods, such as solid-phase-extraction and solid-phase-microextraction.
Designed as an educational and training text, this book provides a clear and easily understandable review of cosmetics and over the counter (OTC) drug-cosmetic products. The text features learning objectives, key concepts, and key terms at the beginning and review questions and glossary of terms at the end of each chapter section. Overviews functions, product design, formulation and development, and quality control of cosmetic ingredients Discusses physiological, pharmaceutical, and formulation knowledge of decorative care products Reviews basic terms and definitions used in the cosmetic industry and provides an overview of the regulatory environment in the US Includes learning objectives, key concepts, and key terms at the beginning and review questions and glossary of terms at the end of each chapter section Has PowerPoint slides as ancillaries, downloadable from the book's wiley.com page, for adopting professors
"Microalgae Biotechnology for Food, Health and High Value Products" presents the latest technological innovations in microalgae production, market status of algal biomass-based products, and future prospects for microalgal applications. It provides stimulating overviews from different perspectives of application that demonstrate how rapidly the commercial production of microalgae-based food, health and high value products is advancing. It also addresses a range of open questions and challenges in this field. The book highlights the latest advances of interest to those already working in the field, while providing a comprehensive overview for those readers just beginning to learn about the promise of microalgae as a sustainable source of both specialty and commercial products. It offers a valuable asset for commercial algae producers, algae product developers, scientific researchers and students who are dedicated to the advancement of microalgae biotechnology for applications in health, diet, nutrition, cosmetics, biomaterials etc.
Praise for the First Edition
This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, and also includes additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech and enzyme replacement therapy.
A MUST-HAVE VOLUME FOR ALL WINE LOVERS Written by renowned orange wine expert and award winning writer Simon J. Woolf, Amber Revolution is the world's first book to tell the full, forgotten story of this ancient wine (white wine made like a red wine) and its modern struggle to gain acceptance. It is a tale of lost identity, the fight for survival, and pioneering winemakers from the Caucasus to the Adriatic. White grapes are left in contact with their skins for days, weeks or months during fermentation, creating stunning complexity, unusual aromas and intense flavors. The extended skin contact gives these wines bold amber, russet, or orange tints. The technique is ancient, but the hype is new and fast growing. This book includes profiles of 180 of the best producers from 20 countries worldwide and is crammed full of all the information you need to find the best orange wines worldwide together with tips for how to buy, enjoy, food-match and age them. Beautifully illustrated
This book highlights the current state-of-the-art regarding the application of applied crystallographic methodologies for understanding, predicting and controlling the transformation from the molecular to crystalline state with the latter exhibiting pre-defined properties. This philosophy is built around the fundamental principles underpinning the three inter-connected themes of Form (what), Formation (how) and Function (why). Topics covered include: molecular and crystal structure, chirality and ferromagnetism, supramolecular assembly, defects and reactivity, morphology and surface energetics. Approaches for preparing crystals and nano-crystals with novel physical, chemical and mechanical properties include: crystallisation, seeding, phase diagrams, polymorphic control, chiral separation, ultrasonic techniques and mechano-chemistry. The vision is realised through examination of a range of advanced analytical characterisation techniques including in-situ studies. The work is underpinned through an unprecedented structural perspective of molecular features, solid-state packing arrangements and surface energetics as well as in-situ studies. This work will be of interest to researchers, industrialists, intellectual property specialists and policy makers interested in the latest developments in the design and supply of advanced high added-value organic solid-form materials and product composites.
Dendrimer science has exploded onto the polymer science scene as the fourth major class of polymer architecture. Capturing the history of dendrimer discovery to the present day, this book addresses all the essential information for newcomers and those experienced in the field, including: * Fundamental theory, chemistry and physics of the 'dendritic state' * Synthetic strategies (click chemistry, self-assembly, and so on) * Dendron/dendrimer characterization techniques * Architecturally driven 'dendritic effects' * Developments in scientific and commercial applications * Convergence with nanotechnology, including dendrimer-based nanodevices, nanomaterials, nanotoxicology and nanomedicine * Dendrimers as a window to a new nano-periodic system. Including first-hand accounts from pre-1995 pioneers, progress in the dendrimer field is brought to life with anticipated developments for the future. This is the ideal book for researchers in both academia and industry who need a complete introduction to the 'dendritic state' with a special focus on dendrimer and dendron polymer science.
This book bridges the gap between theory and practice. It provides fundamental information on heterogeneous catalysis and the practicalities of the catalysts and processes used in producing ammonia, hydrogen and methanol via hydrocarbon steam reforming. It also covers the oxidation reactions in making formaldehyde from methanol, nitric acid from ammonia and sulphuric acid from sulphur dioxide. Designed for use in the chemical industry and by those in teaching, research and the study of industrial catalysts and catalytic processes. Students will also find this book extremely useful for obtaining practical information not available in more conventional textbooks.
The field of bio-based plastics has developed significantly in the last 10 years and there is increasing pressure on industries to shift existing materials production from petrochemicals to renewables. Bio-based Plastics presents an up-to-date overview of the basic and applied aspects of bioplastics, focusing primarily on thermoplastic polymers for material use. Emphasizing materials currently in use or with significant potential for future applications, this book looks at the most important biopolymer classes such as polysaccharides, lignin, proteins and polyhydroxyalkanoates as raw materials for bio-based plastics, as well as materials derived from bio-based monomers like lipids, poly(lactic acid), polyesters, polyamides and polyolefines. Detailed consideration is also given to the market and availability of renewable raw materials, the importance of bio-based content and the aspect of biodegradability. Topics covered include: * Starch * Cellulose and cellulose acetate * Materials based on chitin and chitosan * Lignin matrix composites from natural resources * Polyhydroxyalkanoates * Poly(lactic acid) * Polyesters, Polyamides and Polyolefins from biomass derived monomers * Protein-based plastics Bio-based Plastics is a valuable resource for academic and industrial researchers who are interested in new materials, renewable resources, sustainability and polymerization technology. It will also prove useful for advanced students interested in the development of bio-based products and materials, green and sustainable chemistry, polymer chemistry and materials science. For more information on the Wiley Series in Renewable Resources, visit www.wiley.com/go/rrs
The book deals with the famous query by Richard Feynman, "W"hat would the properties of materials be if we could really arrange the atoms (molecules) the way we want them?"" Feynman also wondered: ""What could we do with layered structures with just the right layers?"" The state of the art in building laminar materials of different kinds for diverse applications is thoroughly covered in this book. After discussing the basic chemistry involved, The basic chemistry involved in the field and the techniques used for techniques are discussed, including: variable porosity; molecular and shape recognition; detection, separation and storage of small molecules; supramolecular chirality; chiral memory and recognition; simple and circularly polarized luminescence; photoactive materials; viii) drug and dye confinement. Applications in biocatalysis, drug delivery, and energy storage and recovery are discussed.
The subject of advanced materials in catalysisbrings together recent advancements in materials synthesis and technologies to the design of novel and smart catalysts used in the field of catalysis. Nanomaterials in general show an important role in chemical processing as adsorbents, catalysts, catalyst supports and membranes, and form the basis of cutting-edge technology because of their unique structural and surface properties. Advanced Catalytic Materials is written by a distinguished group of contributors and the chapters provide comprehensive coverage of the current literature, up-to-date overviews of all aspects of advanced materials in catalysis, and present the skills needed for designing and synthesizing advanced materials. The book also showcases many topics concerning the fast-developing area of materials for catalysis and their emerging applications. The book is divided into three parts: Nanocatalysts Architecture and Design; Organic and Inorganic Catalytic Transformations; and Functional Catalysis: Fundamentals and Applications. Specifically, the chapters discuss the following subjects: * Environmental applications of multifunctional nanocomposite catalytic materials * Transformation of nanostructured functional precursors using soft chemistry * Graphenes in heterogeneous catalysis * Gold nanoparticles-graphene composites material for catalytic application * Hydrogen generation from chemical hydrides * Ring-opening polymerization of poly(lactic acid) * Catalytic performance of metal alkoxides * Cycloaddition of CO2 and epoxides over reusable solid catalysts * Biomass derived fine chemicals using catalytic metal bio-composites * Homoleptic metal carbonyls in organic transformation * Zeolites: smart materials for novel, efficient, and versatile catalysis * Optimizing zeolitic catalysis for environmental remediation
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predictive methods, molecular recognition or lead quality matrices. Novel lead generation approaches for challenging targets like DNA-encoded library screening or chemical biology approaches are treated here side by side with established methods as high throughput and affinity screening, knowledge- or fragment-based lead generation, and collaborative approaches. Within the entire book, a very strong focus is given to highlight the application of the presented methods, so that the reader will be able to learn from real life examples. The final part of the book presents several lead generation case studies taken from different therapeutic fields, including diabetes, cardiovascular and respiratory diseases, neuroscience, infection and tropical diseases. The result is a prime knowledge resource for medicinal chemists and for every scientist involved in lead generation.
Unlike extensive major reference works or handbooks, "Chemical Engineering: Trends and Developments" provides readers with a ready-reference to latest techniques in selected areas of chemical engineering where research is and will be focused in the future. These areas are: bioseparations; particle science and design; nanotechnology; and reaction engineering. The aim of the book is to provide academic and R&D researchers with an overview of the main areas of technical development and how these techniques can be applied. Each chapter focuses on a technique, plus a selection of applications or examples of where the technique could be applied.
An unprecedented guide to successfully start or grow a microbrewery or craft brewery in a much more competitive world. Opening a microbrewery starts with, of course, making great beer. But that is just the beginning. Today's sophisticated patrons are offered an ever-increasing array of options. It's so much more than beer nowadays. Yes, great beer is essential, but to attract and hold on to a loyal customer base, you must create a sense of place. Do your research. Understand financing and cash flow. Know how to measure your success. A successful, well-run microbrewery knows how to hire the right employees--employees that will spread word of your business to friends, family, even total strangers, both on and off the clock. Marketing, branding, customer experience; they all matter. There are so many factors that directly and indirectly contribute to success, it may at times be overwhelming. The Microbrewery Handbook offers an extraordinary look at all of the facets of success in the industry. No matter if you are thinking about starting a new venture or are already operating your own microbrewery, this valuable book offers real-world advice and proven strategies to help you thrive in the competitive micro and craft brewing industry. Focused on practical guidance, author D.C. Reeves distills his experience founding Perfect Plain Brewing Company in Pensacola, Florida into an engaging, up-to-date resource for microbrewers everywhere. Clearly showing readers what works in the industry and, just as importantly, what doesn't work, The Microbrewery Handbook: Helps you create unique, memorable experiences for your customers, your employees, and your city Includes coverage of the financial aspects of building and growing your business, such as banking, investment, and debt Shows you how to transform your business into a community anchor Offers suggestions on building an entire culture around your brand that promotes positivity and attracts the right kind of attention Shares personal stories and advice from a successful microbrew entrepreneur Includes interviews and insight with industry experts as well as owners of some of the nation's elite craft breweries including Sam Calagione of Dogfish Head, Jeffrey Stuffings of Jester King, and Doug Resier of Burial Brewing The Microbrewery Handbook: Craft, Brew, and Build Your Own Microbrewery Success is an indispensable, first-of-its-kind book for anyone in the micro and craft brewing industry.
The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/anti tumor/anti cancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.
Master the principles of thermodynamics with this comprehensive undergraduate textbook, carefully developed to provide students of chemical engineering and chemistry with a deep and intuitive understanding of the practical applications of these fundamental ideas and principles. Logical and lucid explanations introduce core thermodynamic concepts in the context of their measurement and experimental origin, giving students a thorough understanding of how theoretical concepts apply to practical situations. A broad range of real-world applications relate key topics to contemporary issues, such as energy efficiency, environmental engineering and climate change, and further reinforce students' understanding of the core material. This is a carefully organized, highly pedagogical treatment, including over 500 open-ended study questions for discussion, over 150 varied homework problems, clear and objective standards for measuring student progress, and a password-protected solution manual for instructors.
A practical guide to Quality by Design for pharmaceutical product development Pharmaceutical Quality by Design: A Practical Approach outlines a new and proven approach to pharmaceutical product development which is now being rolled out across the pharmaceutical industry internationally. Written by experts in the field, the text explores the QbD approach to product development. This innovative approach is based on the application of product and process understanding underpinned by a systematic methodology which can enable pharmaceutical companies to ensure that quality is built into the product. Familiarity with Quality by Design is essential for scientists working in the pharmaceutical industry. The authors take a practical approach and put the focus on the industrial aspects of the new QbD approach to pharmaceutical product development and manufacturing. The text covers quality risk management tools and analysis, applications of QbD to analytical methods, regulatory aspects, quality systems and knowledge management. In addition, the book explores the development and manufacture of drug substance and product, design of experiments, the role of excipients, multivariate analysis, and include several examples of applications of QbD in actual practice. This important resource: Covers the essential information about Quality by Design (QbD) that is at the heart of modern pharmaceutical development Puts the focus on the industrial aspects of the new QbD approach Includes several illustrative examples of applications of QbD in practice Offers advanced specialist topics that can be systematically applied to industry Pharmaceutical Quality by Design offers a guide to the principles and application of Quality by Design (QbD), the holistic approach to manufacturing that offers a complete understanding of the manufacturing processes involved, in order to yield consistent and high quality products.
Adopting an integrated approach, this book covers experiments, theory, and emerging applications. In the first part surfaces are described that change from flat to either a random corrugated or to a well-structured structure, while the second part deals with those surface structures integrated in the coating surface where the structures change their shape or dimension when addressed by an external trigger. A variety of materials are addressed, including liquid crystal polymers, hydrogels, hard acrylates, and soft silicones. The whole is rounded off by a discussion of various applications, including surface controlled flows in microfluidic systems. Of interest to chemists and engineers, researchers in industry and academia, as well as those working in the paint industry and hydrodynamics.
With its focus on concrete methods and recent advances in applying nanotechnology to develop new drug therapies and medical diagnostics, this book provides an overall picture of the field, from the fundamentals of nanopharmacy with the characterisation and manufacturing methods to the role of nanoparticles and substances. Actual examples of utilization include drug development issues, translation to the clinic, market prospects, and industrial commercialization aspects. The applications described are taken from cancer treatment as well as other major therapeutic areas, such as infectious diseases and dermatology. An in-depth discussion on safety, regulatory, and societal aspects rounds off the book. Written by a top team of editors and authors composed of the leading experts in Europe and the USA who have pioneered the field of nanopharmacy!
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