Scintillation Dosimetry delivers a comprehensive introduction to plastic scintillation dosimetry, covering everything from basic radiation dosimetry concepts to plastic scintillating fiber optics. Comprised of chapters authored by leading experts in the medical physics community, the book: Discusses a broad range of technical implementations, from point source dosimetry scaling to 3D-volumetric and 4D-scintillation dosimetry Addresses a wide scope of clinical applications, from machine quality assurance to small-field and in vivo dosimetry Examines related optical techniques, such as optically stimulated luminescence (OSL) or Cerenkov luminescence Thus, Scintillation Dosimetry provides an authoritative reference for detailed, state-of-the-art information on plastic scintillation dosimetry and its use in the field of radiation dosimetry.

Features • Discusses novel methods of cancer diagnostics and cancer treatment. • Details non and minimally-invasive photonics techniques. • Explores the applications of machine learning and artificial intelligence to these novel techniques.

This book discusses fundamentally new biomedical imaging methods, such as holography, holographic and resonant interferometry, and speckle optics. It focuses on the development of holographic interference microscopy and its use in the study of phase objects such as nerve and muscle fibers subjected to the influence of laser radiation, magnetic fields, and hyperbaric conditions. The book shows how the myelin sheath and even the axon itself exhibit waveguide properties, enabling a fresh new look at the mechanisms of information transmission in the human body. The book presents theoretically and experimentally tested holographic and speckle-optical methods and devices used for investigating complex, diffusely scattering surfaces such as skin and muscle tissue. Additionally, it gives broad discussion of the authors' own original fundamental and applied research dedicated to helping physicians introduce new contact-less methods of diagnosis and treatment of diseases of the cardiovascular and neuromuscular systems into medical practice. The book is aimed at a broad spectrum of scientific specialists in the fields of speckle optics, holography, laser physics, morphology and cytochemistry, as well as medical professionals such as physiologists, neuropathologists, neurosurgeons, cardiologists and dentists.

Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging and radiation therapy. This book provides medical physicists and radiation oncologists current and relevant information on Adaptive Radiation Therapy (ART), a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus delivering highly individualized radiation therapy for cancer patients. The book should also benefit medical dosimetrists and radiation therapists. Adaptive Radiation Therapy describes technological and methodological advances in the field of ART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into three sections (radiobiological basis, current technologies, and clinical applications), the book covers: Morphological and biological biomarkers for patient-specific planning Design and optimization of treatment plans Delivery of IMRT and IGRT intervention methodologies of ART Management of intrafraction variations, particularly with respiratory motion Quality assurance needed to ensure the safe delivery of ART ART applications in several common cancer types / anatomic sites The technology and methodology for ART have advanced significantly in the last few years and accumulated clinical data have demonstrated the need for ART in clinical settings, assisted by the wide application of intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). This book shows the real potential for supplying every patient with individualized radiation therapy that is maximally accurate and precise.

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

This book discusses multiple aspects of radiological and nuclear terrorism. Do you know what to do if there is a radiological or nuclear emergency in your city? These accidents are not common, but they have happened - and even though we have not seen an attack using these weapons, governments around the world are making plans for how to prevent them - and for how to respond if necessary. Whether you are an emergency responder, a medical caregiver, a public health official - even a member of the public wanting to know how to keep yourself and your loved ones safe - there is a need to understand how these weapons work, how radiation affects our health, how to stop an attack from taking place, how to respond appropriately in the event of an emergency, and much more. Unfortunately, the knowledge that is needed to accomplish all of this is lacking at all levels of society and government. In this book, Dr. Andrew Karam, an internationally respected expert in radiation safety and multiple aspects of radiological and nuclear emergencies, discusses how these weapons work and what they can do, how they can affect our health, how to keep yourself safe, and how to react appropriately whether you are a police officer investigating a suspect radiological weapon, a firefighter responding to a radiological or nuclear attack, a nurse or physician caring for potentially contaminated patients, or a governmental official trying to keep the public safe. To do this, he draws upon his extensive experience in the military, the several years he worked directly with emergency responders, his service on a number of advisory committees, and multiple trips overseas in the aftermath of the Fukushima accident and on behalf of the International Atomic Energy Agency, Interpol, and the Health Physics Society.

This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics, injury biomechanics, biomechanics of the heart and vascular system, algorithms of computational biomechanics for medical image analysis, and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, Computational Biomechanics for Medicine: Measurments, Models, and Predictions provides an opportunity for specialists in the field to present their latest methodologies and advancements.

The book sets out to inform a broad range of professionals working in medicine and healthcare about how creative thinking and design concepts can be used to innovate in providing an enhanced patient experience. It outlines these concepts as a primary means to identify, clarify and resolve some of the process improvement and enhancement challenges in healthcare delivery. It demonstrates by example how such challenges can be addressed, drawing on case examples from healthcare and other industries, and from the authors’ own experiences as innovators and educators. It emphasizes the value of learning in action. For the reader who already has a leaning towards novel approaches to addressing healthcare delivery challenges, it provides guidance on harnessing team inputs and engaging with a network of contributors. It is an ideal resource for all working in medicine and healthcare, from managers, nurses, doctors, administrators, executives, and allied health professionals to medical engineers, medical physicists, medical scientists and medical product developers. Features Provides a unique framework to conceptualise innovation in healthcare and medicine. Authored by an award-winning medical scientist and an established business school Professor who have proven track-records with innovation, in education settings and as entrepreneurs. Presents a clear interdisciplinary approach, complemented with practical case studies set in the context of the challenges facing healthcare delivery in the 21st century. Dr. Barry McMahon has a national and international reputation as an Academic Medical Physicist in the fields of novel physiological measurement and medical device innovation and design. He is the co- inventor of the Functional Lumen Imaging Probe (FLIP) technique later commercialised as EndoFLIP™. He was the Director of the Innovation Academy at Trinity College Dublin from 2012 to 2017. Since 2020 he is advising Children’s Health Ireland on innovation practice. In 2021, he retired as Chief Physicist/Clinical Engineer at Tallaght Hospital, Ireland and currently runs his own innovation-consulting group Electric Mindset Ltd. Dr. Paul Coughlan is Professor in Operations Management and Co-Director of Faculty at Trinity Business School, Trinity College Dublin. His research explores collaborative strategic improvement of operations through network action learning. He was the Director of the Innovation Academy at Trinity College Dublin from 2010 to 2012. He is a founding director of a research-based spin-out venture, Easy Hydro Ltd.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires . Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centers in India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

This is the first all-encompassing textbook designed to support trainee clinical scientists in medical physics as they start work in a hospital setting whilst undertaking an academic master's course. Developed by practising physicists and experienced academics using their experience of teaching trainee medical physicists, this book provides an accessible introduction to the daily tasks that clinical scientists perform in the course of their work. It bridges the gap between theory and practice, making the book also suitable for advanced undergraduate and graduate students in other disciplines studying modules on medical physics, including those who are considering a career in medical physics through applying to the NHS Scientist Training Programme (STP). Features: Provides an accessible introduction to practical medical physics within a hospital environment Maps to the course content of the Scientist Training Programme in the NHS Acts as a complement to the academic books often recommended for medical physics courses

The purpose and subject of this book is to provide a comprehensive overview of all types of phantoms used in medical imaging, therapy, nuclear medicine and health physics. For ionizing radiation, dosimetry with respect to issues of material composition, shape, and motion/position effects are all highlighted. For medical imaging, each type of technology will need specific materials and designs, and the physics and indications will be explored for each type. Health physics phantoms are concerned with some of the same issues such as material heterogeneity, but also unique issues such as organ-specific radiation dose from sources distributed in other organs. Readers will be able to use this book to select the appropriate phantom from a vendor at a clinic, to learn from as a student, to choose materials for custom phantom design, to design dynamic features, and as a reference for a variety of applications. Some of the information enclosed is found in other sources, divided especially along the three categories of imaging, therapy, and health physics. To our knowledge, even though professionally, many medical physicists need to bridge the three catagories described above.

Features * The first collective book combining accumulated knowledge and experience in the field of diabetes research using biophotonics. * Contributions from leading experts in the field. * Combines the theoretical base of the described methods and approaches, as well as providing valuable practical guidance and the latest research from experimental studies.

Synchrotron radiation has been a revolutionary and invaluable research tool for a wide range of scientists, including chemists, biologists, physicists, materials scientists, geophysicists. It has also found multidisciplinary applications with problems ranging from archeology through cultural heritage to paleontology. The subject of this book is x-ray spectroscopy using synchrotron radiation, and the target audience is both current and potential users of synchrotron facilities. The first half of the book introduces readers to the fundamentals of storage ring operations, the qualities of the synchrotron radiation produced, the x-ray optics required to transport this radiation, and the detectors used for measurements. The second half of the book describes the important spectroscopic techniques that use synchrotron x-rays, including chapters on x-ray absorption, x-ray fluorescence, resonant and non-resonant inelastic x-ray scattering, nuclear spectroscopies, and x-ray photoemission. A final chapter surveys the exciting developments of free electron laser sources, which promise a second revolution in x-ray science. Thanks to the detailed descriptions in the book, prospective users will be able to quickly begin working with these techniques. Experienced users will find useful summaries, key equations, and exhaustive references to key papers in the field, as well as outlines of the historical developments in the field. Along with plentiful illustrations, this work includes access to supplemental Mathematica notebooks, which can be used for some of the more complex calculations and as a teaching aid. This book should appeal to graduate students, postdoctoral researchers, and senior scientists alike.

This textbook provides an introduction to radiation, the principles of interaction between radiation and matter, and the exploitation of those principles in the design of modern radiation detectors. Both radiation and detectors are given equal attention and their interplay is carefully laid out with few assumptions made about the prior knowledge of the student. Part I is dedicated to radiation, broadly interpreted in terms of energy and type, starting with an overview of particles and forces, an extended review of common natural and man-made sources of radiation, and an introduction to particle accelerators. Particular attention is paid to real life examples, which place the types of radiation and their energy in context. Dosimetry is presented from a modern, user-led point of view, and relativistic kinematics is introduced to give the basic knowledge needed to handle the more formal aspects of radiation dynamics and interaction. The explanation of the physics principles of interaction between radiation and matter is given significant space to allow a deeper understanding of the various technologies based on those principles. Following an introduction to the ionisation mechanism, detectors are introduced in Part II, grouped according to the physical principle that underpins their functionality, with chapters covering gaseous detectors, semiconductor detectors, the scintillation process and light detectors. The final two chapters describe the phenomenology of showers and the design of calorimeters, and cover additional phenomena including Cherenkov and transition radiation and the detection of neutrinos. An appendix offers the reader a useful review of statistics and probability distributions. The mathematical formalism is kept to a minimum throughout and simple derivations are presented to guide the reasoning and facilitate understanding of the working principles. The book is unique in its wide scope and introductory level, and is suitable for undergraduate and graduate students in physics and engineering. The reader will acquire an awareness of how radiation and its exploitation are becoming increasingly relevant in the modern world, with over 140 experimental figures, detector schematics and photographs helping to relate the material to a broader research context.

The rise in living standards increases the expectation of people in almost every field. At the forefront is health. Over the past few centuries, there have been major developments in healthcare. Medical device technology and developments in artificial intelligence (AI) are among the most important ones. The improving technology and our ability to harness the technology effectively by means such as AI have led to unprecedented advances, resulting in early diagnosis of diseases. AI algorithms enable the fast and early evaluation of images from medical devices to maximize the benefits. While developments in the field of AI were quickly adapted to the field of health, in some cases this contributed to the formation of innovative artificial intelligence algorithms. Today, the most effective artificial intelligence method is accepted as deep learning. Convolutional neural network (CNN) architectures are deep learning algorithms used for image processing. This book contains applications of CNN methods. The content is quite extensive, including the application of different CNN methods to various medical image processing problems. Readers will be able to analyze the effects of CNN methods presented in the book in medical applications.

In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine. Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.

"Comprehensive Biomedical Physics "is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, "Comprehensive Biomedical Physics "is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics.

This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics.
The most comprehensive work on biomedical physics ever publishedCovers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicineContains 1800 illustrations, all in full color

Key features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology science examinations

Key features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology science examinations

Cover simple modelling approaches as well as full Monte Carlo simulation of x-ray tubes Bremsstrahlung and characteristic contributions to the spectrum are discussed in detail Learning is supported by free open-source software and an online repository of code.

The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis.

Spreading to every corner of the Earth, the COVID-19 virus has had an unparalleled impact on all aspects of our lives. This book explores in detail how the COVID-19 pandemic has affected clinical practice, education, and research in medical physics, and how colleagues on the frontline dealt with this unpredictable and unprecedented pandemic. It tackles key questions such as: How did medical physicists first respond to the situation? What innovative strategies were taken and how effective were they? How are medical physicists preparing for the future? There will be a focus on the different experiences of regional medical physicists and the responses and outlooks in clinical practice, education, and research in the affected continents, Asia-Pacific, the Middle East, Europe, Africa and North and Latin America. With over 91 contributors from 39 countries, this unique resource contains key perspectives from teams from each territory to ensure a global range of accounts. The collective opinion and wisdom from the major medical physics journal editors-in-chief are also explored, alongside how the pandemic has affected the quantity and quality of publications. Voices of early-career researchers and students of medical physics will be included, with narratives of their experiences coping with life during the pandemic. Lastly, communicating leadership in times of adversity is highlighted. This book will be a historic account of the impact of the COVID-19 virus on the field of medical physics. It will be an ideal reference for medical physicists, medical physics trainees and students, hospital administrators, regulators, and healthcare professionals allied with medical physics. Key features: The first book to cover the impact of COVID-19 on the field of medical physics Edited by two experts in the field, with chapter contributions from subject area specialists around the world Broad, global coverage, ranging from the impact on teaching, research, and publishing, with unique perspectives from journal editors and students and trainees

This volume presents a selection of articles based on inspiring lectures held at the "Capri" Advanced Summer School, an original event conceived and promoted by Leonida Antonio Gizzi and Ralph Assmann that focuses on novel schemes for plasma-based particle acceleration and radiation sources, and which brings together researchers from the conventional accelerator community and from the high-intensity laser-matter interaction research fields. Training in these fields is highly relevant for ultra-intense lasers and applications, which have enjoyed dramatic growth following the development of major European infrastructures like the Extreme Light Infrastructure (ELI) and the EuPRAXIA project. The articles preserve the tutorial character of the lectures and reflect the latest advances in their respective fields. The volume is mainly intended for PhD students and young researchers getting started in this area, but also for scientists from other fields who are interested in the latest developments. The content will also appeal to radiobiologists and medical physicists, as it includes contributions on potential applications of laser-based particle accelerators.

Are Amazon Alexa and Google Home limited to our bedrooms, or can they be used in hospitals? Do you envision a future where physicians work hand-in-hand with voice AI to revolutionize healthcare delivery? In the near future, clinical smart assistants will be able to automate many manual hospital tasks-and this will be only the beginning of the changes to come. Voice AI is the future of physician-machine interaction and this Focus book provides invaluable insight on its next frontier. It begins with a brief history and current implementations of voice-activated assistants and illustrates why clinical voice AI is at its inflection point. Next, it describes how the authors built the world's first smart surgical assistant using an off-the-shelf smart home device, outlining the implementation process in the operating room. From quantitative metrics to surgeons' feedback, the authors discuss the feasibility of this technology in the surgical setting. The book then provides an in-depth development guideline for engineers and clinicians desiring to develop their own smart surgical assistants. Lastly, the authors delve into their experiences in translating voice AI into the clinical setting and reflect on the challenges and merits of this pursuit. The world's first smart surgical assistant has not only reduced surgical time but eliminated major touch points in the operating room, resulting in positive, significant implications for patient outcomes and surgery costs. From clinicians eager for insight on the next digital health revolution to developers interested in building the next clinical voice AI, this book offers a guide for both audiences.