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This set of two books dedicated to presenting the latest novel and advanced research from around the world in this exciting area. These books highlight the important properties of electrochemistry in ionic liquids - as opposed to the more commonly used aqueous and organic environments - and the many applications. Readers will find 20 chapters gathered in two books: The first volume critically discusses electrode-electrolyte interfacial processes, reference electrodes, ultramicroelectrode voltammetry and scanning electrochemical microscopy, semi-integral and convolution voltammetry, and small-angle X-ray scattering coupled with voltammetry. The structure and properties of protic ionic liquids, deep-eutectic solvents, task-specific ionic liquids, polymeric ion gels, and lithium-ion solvation, useful for electrochemical application is also critically discussed The second volumes major topics covered in this book include electrodeposition and electroless deposition, voltammetry of adhered microparticles, electrochemistry of organic and organometallic compounds, electrocatalytic reactions, oxygen reduction reaction, ionic liquids in surface protection and lubrication, current industrial application of ionic liquids, and challenges, issues and recycling methods of ionic liquids in industrial developments.
This second edition of Water Activity in Foods furnishes those working within food manufacturing, quality control, and safety with a newly revised guide to water activity and its role in the preservation and processing of food items. With clear, instructional prose and illustrations, the book's international team of contributors break down the essential principles of water activity and water-food interactions, delineating water's crucial impact upon attributes such as flavor, appearance, texture, and shelf life. The updated and expanded second edition continues to offer an authoritative overview of the subject, while also broadening its scope to include six newly written chapters covering the latest developments in water activity research. Exploring topics ranging from deliquescence to crispness, these insightful new inclusions complement existing content that has been refreshed and reconfigured to support the food industry of today.
Hygienic food and water are essential for healthy life. Outbreaks of pathogens and chemical food poisoning occur regularly in this world, which kills around 2.2 million people globally every year. Food recalls due to the presence of food-borne pathogens and toxic chemicals are a nightmare for world economic growth. Even in the 21st century, due to the biological diversity and low infection dose, it is a continual challenge to prevent infectious disease outbreaks due to harmful pathogens. To tackle these challenges, the source of food poisoning and adverse health effects are one of the fastest growing research and technology areas in the last twenty years. This book contains ten chapters covering basic science to possible device design which can have immense applications in our society.
This second, extended and updated edition presents the current state of kinetics of chemical reactions, combining basic knowledge with results recently obtained at the frontier of science. Special attention is paid to the problem of the chemical reaction complexity with theoretical and methodological concepts illustrated throughout by numerous examples taken from heterogeneous catalysis combustion and enzyme processes. Of great interest to graduate students in both chemistry and chemical engineering.
The New Benchmark for Understanding the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs. Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.
Unit Operations of Chemical Engineering, 7th edition continues its lengthy, successful tradition of being one of McGraw-Hill's oldest texts in the Chemical Engineering Series. Since 1956, this text has been the most comprehensive of the introductory, undergraduate, chemical engineering titles available. Separate chapters are devoted to each of the principle unit operations, grouped into four sections: fluid mechanics, heat transfer, mass transfer and equilibrium stages, and operations involving particulate solids. Now in its seventh edition, the text still contains its balanced treatment of theory and engineering practice, with many practical, illustrative examples included. Almost 30% of the problems have been revised or are new, some of which cover modern topics such as food processing and biotechnology. Other unique topics of this text include diafiltration, adsorption and membrane operations.
For more than 50 years, the Springer VDI Heat Atlas has been an indispensable working means for engineers dealing with questions of heat transfer. Featuring 50% more content, this new edition covers most fields of heat transfer in industrial and engineering applications. It presents the interrelationships between basic scientific methods, experimental techniques, model-based analysis and their transfer to technical applications.
Applications of nanotechnology are the remarkable sizes dependent on physiochemical properties of nanomaterials that have led to the developed protocols for synthesizing nanomaterials over a range of size, shapes and chemical compositions. Nanomaterials are normally powders composed of nanoparticles which exhibit properties that are different from powders. Nanotechnology is the engineering of functional systems at the molecular scale with their wide applications in energy sector, including -but not limited to- energy resources, energy conversion, energy storage, and energy usage; drug delivery systems including- safety concerns, perspective, challenges, target therapeutics for cancer, neurodegenerative diseases and other human diseases, nanomaterials based tissue engineering; and food sectors including to- food safety and quality, opportunities, challenges, nanomaterials based enhancing food packing, and determination of foodborne pathogens, agro and marine food, analysis of market, regulations and future prospects. The utilization of nanotechnology in the energy field will be emphasized and highlighted, in accordance to their prominent and high impact in this particular field. Recent trends and significant benefits of nanotechnology in the energy field will be revealed to the readers, and their promising advanced applications will be discussed. The current drug discovery paradigm constantly needs to improve, enhance efficiency and reduce time to the market on the basis of designing new drug discovery, drug delivery and pharmaceutical manufacturing. In this book will be highlighted nanotechnology based drug delivery is an important aspect of medicine, as more potent and specific drugs that are particularly discussed the understanding of disease pathways. Several biomaterials can be applied to small-molecule drugs as controlled release reservoirs for drug delivery and provide new insights into disease processes, thus understanding the mechanisms of action of drugs. Applications of food nanotechnology are an area of emerging interest for the food industry, for the reason, in this book will be given more priority to discuss the uses of nanomaterials for food packing, food safety and quality, and to remove the contaminated or spoiled by foodborne pathogens. And also nanotechnology based food products will be discussed how making them tastier, healthier, and more nutritious such as vitamins, to reduce fat content, and to ensure they do not degrade during a product's shelf life. Nanotechnology is basically the uses of nanomaterials, devices and systems through the control of matter on the nanometer scale. Multidisciplinary studies are required the technology for discovery and moving so fast from concept to the reality. Nanotechnology always not only provided more benefits in energy, drugs and food products but also provided significantly benefits around multidisciplinary field applications.
A guide to membrane separation based on a variety of porous materials with promising separation applications Microporous Materials for Separation Membranes offers an in-depth guide that explores microporous materials? potential for membrane applications. The authors?two experts on the topic?examine a wide range of porous materials that have application potential including: microporous silica, porous carbons, zeolites, metal-organic frameworks (MOFs), and porous organic frameworks (POFs). Comprehensive in scope, the book covers a broad range of topics on membrane separations such as: hydrogen recovery, carbon dioxide capture, air purification, hydrocarbon separation, pervaporation, and water treatment. In addition, this up-to-date resource explores the most recent materials for preparing microporous membranes and explores the most promising applications for industrial use. This important book: -Examines the use of microporous materials as membranes to perform with different gases and liquids -Offers an overview of the basic knowledge of membrane separation and an intense examination of separations -Describes the state-of-the-art of membrane separation with porous materials -Highlights the most promising applications of industrial interest Written for scientists working in the fields of membranes, gas and liquid, Microporous Materials for Separation Membranes offers a valuable guide to the potential of microporous materials for membrane applications.
This book is a practical guide to optical, optoelectronic, and semiconductor materials and provides an overview of the topic from its fundamentals to cutting-edge processing routes to groundbreaking technologies for the most recent applications. The book details the characterization and properties of these materials. Chemical methods of synthesis are emphasized by the authors throughout the publication. Describes new materials and updates to older materials that exhibit optical, optoelectronic and semiconductor behaviors; Covers the structural and mechanical aspects of the optical, optoelectronic and semiconductor materials for meeting mechanical property and safety requirements; Includes discussion of the environmental and sustainability issues regarding optical, optoelectronic, and semiconductor materials, from processing to recycling.
The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. It is internationally recognised as the authoritative source of information on pharmaceutical excipients and a comprehensive guide to uses, properties and safety. Monographs benefit from a standardized, easy-to-use template and include: Pharmacopeial information from the UK, Europe, Japan and the United States where relevant Non-proprietary names and synonyms Chemical name, CAS Registry number, empirical formula, molecular weight Functional category, applications and incompatibilities Material description and typical properties Safety, stability, storage and handling information Method of manufacture Related substances Primary references Editorial comments Authors details and revision date Changes to this new edition: Contains revised and updated monographs 20 + new monographs including amino acids Arginine, Proline and Asparagine Includes newly added Raman spectra for many excipients New chapter content including information on excipients in oral solid dose formulations, and pediatric formulations
Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: Design considerations in biophysical-based lead screening Thermodynamic characterization of protein-compound interactions Characterizing targets and screening reagents with HDX-MS Microscale thermophoresis methods (MST) Screening with Weak Affinity Chromatography Methods to assess compound residence time 1D-NMR methods for hit identification Protein-based NMR methods for SAR development Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.
Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. This book and its accompanying CD-ROM comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management. Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries Includes a CD with downloadable training courses that can be adopted and directly customized to a particular organization Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the CD supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.
Taste is the number one driving force in the decision to purchase a food product and food consumption is the most critical function for living organisms to obtain the energy and resources essential to their vitality. Flavor and aroma are therefore universally important concepts: intrinsic to human well-being and pleasure, and of huge significance for the multi-trillion dollar global food business. How Flavor Works: the Science of Taste and Aroma offers a fascinating and accessible primer on the concepts of flavor science for all who have an interest in food and related topics. Professionals and students of food science and technology who do not already specialize in flavor science will find it a valuable reference on a topic crucial to how consumers perceive and enjoy food products. In this regard, it will also be of interest to product developers, marketers and food processors. Other readers with a professional (eg culinary and food service) or personal interest in food will also find the book interesting as it provides a user-friendly account of the mechanisms of flavor and aroma which will provide new insights into their craft.
Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.
Alle Abbildungen zur 3. Auflage des CHMIEL (Hrsg.), Bioprozesstechnik. 3.A.
Die 3., berarbeitete und aktualisierte Auflage dieses Fachbuchs bietet eine Einf hrung in die Grundlagen der Bioprozesstechnik und erl utert die wichtigsten Parameter und deren Verhalten bei der Ma stabs bertragung. Damit liegt es voll "im Trend," denn es hilft Studenten der Biotechnologie und Ingenieurwissenschaften die an sie im Studium, in der Forschung und der industriellen Praxis gestellten Aufgaben zu erf llen
Das Werk beginnt mit einer Einf hrung in die Zellbiologie und Biochemie. Es folgen Beitr ge zur Kinetik von Enzymen und Mikroorganismen. Weitere Kapitel besch ftigen sich mit den Flie eigenschaften von Biosuspensionen und deren Einfluss auf Transportvorg nge im Bioreaktor. Die Funktionsweise von Bioreaktoren und das Problem der Sterilit t sowie die Mess- und Regeltechnik werden ausf hrlich behandelt. Mehr als die H lfte der Kosten eines Bioprodukts entfallen auf die Aufarbeitung; ihr wird deshalb besondere Beachtung geschenkt. Das Werk endet mit einem Kapitel zu den verfahrenstechnischen Besonderheiten von h heren Eukaryoten und Enzymen.
During the past decades, enormous progress and enhancement of pharmaceutical manufacturing equipment and its use have been made. And while there are support documents, books, articles, and online resources available on the principles of cleaning and associated processing techniques, none of them provides a single database with convenient, ready-to-use training tools. Until now. Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries elucidates how to train the man power involved in development, manufacturing, auditing, and validation of bio pharmaceuticals on a pilot scale, leading to scale-up production. With over 20 easy-to-use template protocols for cleaning validation of extensively used equipments, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors' more than two decades of experience in the pharmaceutical and biotech industries, the text offers hands-on training based on current approaches and techniques. The book does not merely provide guidelines or thought processes, rather it gives ready-to-use formulas to develop Master Plan, SOPs, and validation protocols. It includes cleaning procedures for the most commonly used equipment in various manufacturing areas and their sampling points, using a pharmaceutical manufacturing site with both sterile and non-sterile operations as the case facility. It also provides the training guidelines on a CD-ROM to enable users to amend or adopt them as necessary. Grounded in practicality, the book's applicability and accessibility set it apart. It can be used as a guide for implementing a cleaning validation program on site without the help of external consultants, making it a resource that will not be found collecting dust on a shelf, but rather, referred to again and again.
Dieses kompakte EinfA1/4hrungslehrbuch vermittelt die wesentlichen Grundlagen der Technischen Chemie. Es richtet sich in erster Linie an Studierende der Chemie sowie des Chemie- und des Bioingenieurwesens und setzt lediglich solide Grundkenntnisse in organischer, anorganischer und physikalischer Chemie voraus. Das Werk ist in 19 etwa gleich lange Kapitel unterteilt, die jeweils ungefAhr dem Umfang einer doppelstA1/4ndigen Vorlesung mit Aoebung entsprechen. Die A1/4berschaubaren Einheiten erleichtern es auch, sich den Inhalt im Selbststudium anzueignen. Die vier KapitelblAcke a žGrundlagen," a žReaktions- und Trenntechnik," a žVerfahrensentwicklung" und a žChemische Prozesse" folgen im Wesentlichen dem a žLehrprofil Technische Chemie" des DECHEMA-Unterrichtsausschusses fA1/4r Technische Chemie.
Jedes Kapitel ist kompakt aufgebaut und mit Abbildungen, Gleichungen, FlieAschemata, Tabellen, Apparatezeichnungen und Fotos anschaulich gestaltet. Die Kapitel enden jeweils mit einer kurzen Zusammenfassung, den a žTake Home Messages." Diese rekapitulieren noch einmal alle wesentlichen Aussagen des Kapitels und ermAglichen eine zA1/4gige Wiederholung des Lernstoffes. ErgAnzt wird jedes Kapitel durch zehn kurze Testfragen, die sogenannten a žQuickies," die sich nach sorgfAltigem Durcharbeiten des Textes schnell lAsen lassen; die Antworten stehen zudem am Ende des Buches. Dort findet man ferner zu allen Kapiteln die Literaturangaben, die sich auf wesentliche Nachschlagewerke und LehrbA1/4cher konzentrieren.
Encompassing both biotechnology and chemical engineering, Microbial Functional Foods and Nutraceuticals brings together microbiology, bacteria and food processing/mechanization, which have applications for a variety of audiences: pharmaceuticals, diagnostics and medical device development all employ microbial food technology. The book will cover recent advances in microbial functional foods and associated applications, and will form an important reference work for graduates and researchers. The book will also provide up-to-date information on novel nutraceutical compounds and their mechanisms of action, catering to the needs of researchers and academics in food science and technology, microbiology, chemical engineering and other disciplines who are dealing with microbial functional foods and related areas.
Mayonnaise "takes" when a series of liquids form a semisolid consistency. Eggs, a liquid, become solid as they are heated, whereas, under the same conditions, solids melt. When meat is roasted, its surface browns and it acquires taste and texture. What accounts for these extraordinary transformations?
The answer: chemistry and physics. With trademark clarity and wit, Herve This launches a wry investigation into the chemical art of cooking. Unraveling the science behind common culinary technique and practice, Herv? This breaks food down to its molecular components and matches them to cooking's chemical reactions. He translates the complex processes of the oven into everyday knowledge for professional chefs and casual cooks; demystifies the meaning of taste and the making of flavor; describes the properties of liquids, salts, sugars, oils, and fats; and defines the principles of culinary practice, which endow food with sensual as well as nutritional value.
For fans of Herv? This's popular volumes and for newcomers to his celebrated approach, "The Science of the Oven" fuses the physiology of taste to the molecular structure of bodies and food, expertly expanding the possibilities of the kitchen.
Offering a unique perspective summarizing research on this timely important topic around the globe, this book provides comprehensive coverage of how molecular biomass can be transformed into sustainable polymers. It critically discusses and compares a few classes of biomass - oxygen-rich, hydrocarbon-rich, hydrocarbon and non-hydrocarbon (including carbon dioxide) as well as natural polymers - and equally includes products that are already commercialized. A must-have for both newcomers to the field as well as established researchers in both academia and industry.
This book is the second of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. In this volume, the focus is on the improvement of HDL, enhancement of its functionality, and the use of HDL for therapeutic purposes. In the first section, up-to-date information is provided on such topics as the tumor regression-promoting and antidiabetic activities of reconstituted HDL containing V156K apolipoprotein A-I, the enhancement of HDL effects by high doses of vitamin C, the benefits derived from incorporation of growth hormones 1 and 2 into rHDL, and the biological functions of omega-3 linolenic acid in rHDL. The enhancement of HDL functionality by policosanol and the resultant benefits are thoroughly examined in a separate section. Readers will also find the latest information on clinical applications of HDL. Here, specific topics include the enhancement of adenoviral gene delivery and the delivery of rapamycin. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians.
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