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With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.
Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products-from drug powders for respiratory delivery to drug delivery systems for controlled release.
Teaching the fundamental knowledge required for successful
dispersion of powders in a liquid, this book covers a host of
topics -- from recent advances to industrial applications.
This book comprehensively describes biological phenomena, adaptation mechanisms, and strategies of living organisms to survive under extremely cold or desiccated conditions at molecular, cellular, and organ levels. It also provides tremendous potential for applications of the findings to a wide variety of industries. The volume consists of three parts: Part 1, Adaptation Mechanisms of Cold, and Part 2, Adaptation Mechanisms of Desiccation, collect up-to-date research on mechanisms and strategies of living organisms such as sleeping chironomids, polar marine fishes, hibernating mammals, bryophytes, dormant seeds, and boreal plants to survive under extreme cold and desiccated conditions at molecular, cellular, and organ levels. Part 3, Application Technologies from Laboratory to Society, covers various applications to a wide variety of industries such as the medical, food, and agricultural and life science industries. For example, biological knowledge of how plants and animals survive under cold, drought, and desiccated conditions may provide a hint on how we can improve crop production in a very fragile environment in global climate change. Unique molecules that protect cells during desiccation and freezing such as trehalose and antifreeze protein (AFP) have potential for use to preserve cells, tissues, and organs for the long term under very stable conditions. In addition, the current progress of supercooling technology of cells may lead us to solve problems of cellular high sensitivity to freezing injury, which will dramatically improve the usability of these cells. Furthermore, knowledge of water substitution and glass formation as major mechanisms for formulation designs and new drying technologies will contribute to the development of food preservation and drug delivery systems under dry conditions. Written by contributors who have been conducting cutting-edge science in related fields, this title is recommended to a wide variety of readers who are interested in learning from such organisms their strategies, mechanisms, and applications, and it will inspire researchers in various disciplines.
Technological Interventions in Processing of Fruits and Vegetables presents a wide selection of the latest concepts in the fast-changing field of processing of fruits and vegetables (FAV). It provides key information on many new and different techniques used for processing of fruits and vegetables while also exploring the pros and cons of the various methods. There is an urgent need to explore and investigate waste in the processing of fruits and vegetables and how different processing technologies can be used most effectively. This volume, in short, conveys the key concepts and role of different technology in processing of fruits and vegetables, keeping mind the special processing requirements of fruits and vegetables, waste issues, nutritional value, and consumer concerns. This volume offers a wealth of information on today's technology for fruit and vegetable processing and will be a valuable resource for industry professionals, agricultural/food processing researchers, faculty and upper-level students, and others.
This book deals with the surface finishing for corrosion prevention from the viewpoint of environmental friendliness. Surface finishing for metallic materials or by metallic materials has excellent corrosion resistance, wear resistance and good color tones, which have been useful for practical applications so far. However, environmental friendliness and user friendliness have become important factors for practical use since the turn of the century. Surface Finishing Industries are now facing a serious crossroad to continue sustainable developments in the future. Sadly, the concept of environmental friendliness is very new, because from the beginning of this discipline (surface finishing), not many people considered the environmental effects so seriously, but sought mainly for the functions, performance, characteristics, and economic profits. Since the biological evaluation processes are very advanced and still debated, this book is very unique and advanced. This book aims to let university students know and learn the concept of environmental friendliness and its relation to surface treatment products based on the fundamental knowledge about conventional corrosion control and surface finishing. The textbook will be used most effectively with subjects such as surface science, surface engineering, mechanical materials, etc. for those studying mechanical engineering, materials engineering and chemical engineering. It is also applicable to practical engineers and researchers in the industrial world as well as the academic one. Throughout this book, readers learn and appreciate the environmentally friendly approaches that are presented for corrosion control and surface finishing.
Advanced Polymeric Materials: Structure Property Relationships addresses the issues, characterization, durability, processing, and properties of state-of-the-art polymers. In chapters contributed by international experts-all in the vanguard of their respective specialties-it explores four distinct areas of the field that are now undergoing explosive growth: fiber reinforced composites, nanocomposites, polymer blends, and bioengineering. This welcome narrative treatment presents a unique, one-stop opportunity to discover the latest research on polymer modification from laboratories around the world.
An up-to-date overview of the dynamic field of whey protein utilization Whey Protein Production, Chemistry, Functionality and Applications explores the science and technology behind the rapidly increasing popularity of this most versatile of dairy by-products. With its richly nutritious qualities, whey protein has been widely used in the food industry for many years. The last decade has, however, seen manufacturers develop many innovative and exciting new applications for it, both in food and other areas. Taking account of these advances, this insightful work offers a full explanation of the technological and chemical breakthroughs that have made whey protein more in-demand than ever before. Topics covered include manufacturing technologies, thermal and chemical modifications, non-food uses, denaturation and interactions, and more. In its broad scope, the book encompasses: An up-to-date overview of recent developments and new applications Breakdowns of the chemical, nutritional, and functional properties of whey protein Commentary on the current and future outlooks of the whey protein market Examinations of the methods and manufacturing technologies that enable whey protein recovery A full guide to the numerous applications of whey protein in food production and other industries Whey Protein Production, Chemistry, Functionality and Applications is an unparalleled source of information on this highly adaptable and much sought-after commodity, and is essential reading for food and dairy scientists, researchers and graduate students, and professionals working in the food formulation and dairy processing industries.
This reference describes the management, control, and prevention of microbial foodborne disease. It analyzes transformations in the epidemiology of foodborne disease from increased transnational food exchange to examinations of new and emerging zoonoses. The authors discuss the prevalence and risk of foodborne disease in developing and industrialized countries. The Annals of Microbiology describes this book as "highly exhaustive, with up to date references." Researchers and practicing pathologists will find this wealth of information vital to continued growth in the field.
The Handbook of Postharvest Technology presents methods in the manufacture and supply of grains, fruits, vegetables, and spices. It details the physiology, structure, composition, and characteristics of grains and crops. The text covers postharvest technology through processing, handling, drying and milling to storage, packaging, and distribution. Additionally, it examines cooling and preservation techniques used to maintain the quality and the decrease spoilage and withering of agricultural products.
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community.
Discussing methods of enzyme purification, characterization, isolation, and identification, this book details the chemistry, behavior, and physicochemical properties of enzymes to control, enhance, or inhibit enzymatic activity for improved taste, texture, shelf-life, nutritional value, and process tolerance of foods and food products. The book covers general aspects of enzymology and the biotechnological strategies for enzyme discovery and development. It describes prototypic enzymes of the six chemical types of reactions catalyzed by enzymes, addressing what the enzymes do, their importance to feed and food production, their chemical and biological properties, and measurement of their activity.
Highlighting a broad range multiscale modeling and methods for anticipating the morphologies and the properties of interfaces and multiphase materials, this reference covers the methodology of predicting polymer properties and its potential application to a wider variety of polymer types than previously thought possible. A comprehensive source, the book features discussions of the interplay between thermodynamic and kinetic factors in multiphase materials, analytical and numerical methods for predicting thermoelastic and transport properties of multiphase materials, mechanical properties under large deformation, and influence of interfaces via simulations.
Due to the consequences of globa l warming and significant greenhouse gas emissions, several ideas have been studied to reduce these emissions or to suggest solut ions for pollutant remov al. The most promising ideas are reduced consumption, waste recovery and waste treatment by biological systems. In this latter category, studies have demonstrated that the use of microalgae is a very promising solution for the biofixation of carbon dioxide. In fact, these micro-organisms are able to offset high levels of CO2 thanks to photosynthesis. Microalgae are also used in various fields (food industry, fertilizers, biofuel, etc.). To obtain a n optimal C O2 sequestration us ing micr oal gae, their cul tivatio n has to be c arried ou t in a f avorable e nvironment, corresponding to optimal operating conditions (temperature, nutrients, pH, light, etc.). Therefore, microalgae are grown in an enclosure, i.e. photobioreactors, which notably operate in continuous mode. This type of closed reactor notably enables us to reduce culture contamination, to improve CO2 transfer and to better control the cultivation system. This last point involves the regulation of concentrations (biomass, substrate or by-product) in addition to conventional regulations (pH, temperature). To do this, we have to establish a model of the system and to identify its parameters; to put in place estimators in order to rebuild variables that are not measured online (software sensor); and finally to implement a control law, in order to maintain the system in optimal conditions despite modeling errors and environmental disturbances that can have an influence on the system (pH variations, temperature, light, biofilm appearance, etc.).
Building upon the success of the bestselling first volume, Functional Foods: Biochemical and Processing Aspects, Volume II explores new sources of nutraceutical and functional food ingredients and addresses crucial issues for product development and processing. It presents the latest developments in the chemistry, biochemistry, pharmacology, epidemiology, engineering, and processing of functional foods. The book provides recent information on important functional food components, including up-to-date evaluations of bioactive compounds. Presenting information on the distribution of functional food components in different sources and their engineering properties, this book provides the essential information for the food industry to develop successful new products.
Discover all the answers to your wine-based fears and never pick a 'bad' bottle again with this fun and accessible guide to everything red, white, rose and sparkling. If you've ever stood and stared blankly at a supermarket wall full of (potentially) delicious wines, not knowing what to choose, if the price is right or frankly, where to start, help is at hand with this little book of terms, tips and cocktail treats about the mother of all drinks: wine. From your red Merlots and Malbecs, to your white Chardonnays and Pinots, through to pink-hued roses and everything bubbly, all the stress usually ensued from trying to choose a half-decent bottle will be taken away as you learn how to say what you're buying, get to grips with the label, grape and quality and - for when the party gets started - discover how and what to serve it with, for every type of occasion. Whether you're hosting a dinner party of a specific cuisine, selecting from a menu at your local restaurant or just want to learn how to make a fruity wine cocktail, this book will show you how to pick the right wine, every time!
This state-of-the-art reference/text presents the most recent techniques in advanced process modeling, identification, prediction, and parameter estimation for the implementation and analysis of industrial systems-providing current applications for the identification of linear and nonlinear systems, the design of generalized predictive controllers (GPCs), and the control of multivariable systems. Contains numerous algorithms and worked out examples for contemporary control techniques Exploring fixed parameter and adaptive strategies as well as unconstrained and constrained identification and control of processes, Advanced Process Identification and Control discusses the design of power series, neural networks, and fuzzy systems the Wiener and Hammerstein systems the design of a multivariable GPC based on state-space representation selection of the most efficient input-output pairing for the design of effective distributed controllers decoupling at high and low frequencies fluidized bed combustion, binary distillation columns, two-tank systems, pH neutralization, fermentors, and tubular chemical reactors With more than 1200 equations, references, drawings, and tables, Advanced Process Identification and Control is a valuable source for chemical, electrical, mechanical, electronics, and control engineers, and an essential text for upper-level undergraduate and graduate students in these disciplines.
Develop the untapped possibilities of this potential tourist El Dorado Given its size, location, cultural attractions, and natural beauty, South America gets far less of the international tourist dollar than it deserves. This valuable book identifies and explores the major issues that influence and shape tourism in South America. Tourism in South America includes original empirical research into the image people have of this varied continent, the factors that draw people to visit South America, and the fears, lack of knowledge, and negative images that can keep tourists away.Tourism in South America examines current practices and suggests alternative models of development. Its informative discussions range from cultural tourism to sustainable tourism to developing human resources. The original empirical research in this volume offers unique insights, and reference notes are included.The reader will encounter varied points of view in Tourism in South America. You can expect to: view Australian travel industry perspectives on Latin American tourism explore the impact of tourism on the Argentina's Patagonian Coast examine the environmental tactics that Mexican and Jamaican hotel companies employ survey the recreation preferences of hikers in a Colombian National Park ponder the implications of performing traditional dances for modern tourists in the AmazonTour operators, hotel managers, local tourism boards, and others seeking the attention of tourists will profit from the new strategies and original research presented in Tourism in South America.
With a focus on actual industrial processes, e.g. the production of light alkenes, synthesis gas, fine chemicals, polyethene, it encourages the reader to think "out of the box" and invent and develop novel unit operations and processes. Reflecting today's emphasis on sustainability, this edition contains new coverage of biomass as an alternative to fossil fuels, and process intensification.
The second edition includes: New chapters on Process Intensification and Processes for the Conversion of BiomassUpdated and expanded chapters throughout with 35% new material overallText boxes containing case studies and examples from various different industries, e.g. synthesis loop designs, Sasol I Plant, Kaminsky catalysts, production of Ibuprofen, click chemistry, ammonia synthesis, fluid catalytic crackingQuestions throughout to stimulate debate and keep students awake Richly illustrated chapters with improved figures and flow diagrams
"Chemical Process Technology, Second Edition" is a comprehensive introduction, linking the fundamental theory and concepts to the applied nature of the subject. It will be invaluable to students of chemical engineering, biotechnology and industrial chemistry, as well as practising chemical engineers.
From reviews of the first edition:
""The authors have blended process technology, chemistry and thermodynamics in an elegant manner... Overall this is a welcome addition to books on chemical technology."" - The Chemist
""Impressively wide-ranging and comprehensive... an excellent textbook for students, with a combination of fundamental knowledge and technology."" - Chemistry in Britain (now Chemistry World)
Develop the untapped possibilities of this potential tourist El Dorado Given its size, location, cultural attractions, and natural beauty, South America gets far less of the international tourist dollar than it deserves. This valuable book identifies and explores the major issues that influence and shape tourism in South America. Tourism in South America includes original empirical research into the image people have of this varied continent, the factors that draw people to visit South America, and the fears, lack of knowledge, and negative images that can keep tourists away. Tourism in South America examines current practices and suggests alternative models of development. Its informative discussions range from cultural tourism to sustainable tourism to developing human resources. The original empirical research in this volume offers unique insights, and reference notes are included. The reader will encounter varied points of view in Tourism in South America.You can expect to: view Australian travel industry perspectives on Latin American tourism explore the impact of tourism on the Argentina's Patagonian Coast examine the environmental tactics that Mexican and Jamaican hotel companies employ survey the recreation preferences of hikers in a Colombian National Park ponder the implications of performing traditional dances for modern tourists in the Amazon Tour operators, hotel managers, local tourism boards, and others seeking the attention of tourists will profit from the new strategies and original research presented in Tourism in South America.
This book comprehensively details the applications of ionic liquids in rare earth green separation and utilization based on the unique interactions of ionic liquids with rare earth ions. It consists of nine chapters demonstrating the synthesis and properties of ionic liquids, coordination chemistry of ionic liquids and rare earth, ionic liquids as diluents, extractants, adsorption resins for rare earth extraction and separation, electrodeposition of rare earth metals in ionic liquids, and preparation of rare earth material with the aid of ionic liquids. It is both interesting and useful to chemists, metallurgists and graduate students working on fundamental research of ionic liquids as well as professionals in the rare earth industry. It provides considerable insights into green chemistry and sustainable processes for rare earth separation in order to meet the environmental challenge of rare earth metallurgy around the globe, especially in China. Ji Chen is a Professor of Chemistry at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China.
Preparing Participants for Intergenerational Interaction: Training for Success examines established intergenerational programs and provides the training methods necessary for activity directors or practitioners to start a similar program. This book contains exercises that will help you train colleagues and volunteers for these specific programs and includes criteria for activity evaluations. Preparing Participants for Intergenerational Interaction will help you implement programs that enable older adults to build friendships, pass down their skills and knowledge to adolescents, and provide youths with positive role models.Discussing the factors that often limit the interaction of older adults with youths, this text stresses the importance of conveying information and history to younger generations. You will learn why the exchange between different generations is crucial to society and to the improvement of the community in which you live. Preparing Participants for Intergenerational Interaction provides you with proven suggestions and methods that will make your program successful, including: examining Howe-To Industries, a program that teaches entrepreneurial skills to youths through older adults focusing on activities between older adults and youths that address aging sensitivity and racial and ethnic understanding defining the roles of a mentor, including teacher, trainer, developer of talent, and counselor increasing support and understanding in your community by defining target markets and selling the project to the public describing the aspects of group dynamics and how group decisionmaking methods are used to assess the success of the program and its volunteers understanding the community where participants live in order to address issues important to them, such as poverty and other social problems Containing sample handouts, self-evaluations, and detailed lessons for different types of programs, this book offers you guidelines that apply to participants that have a variety of needs within different communities. Preparing Participants for Intergenerational Interaction: Training for Success will enable you to help older adults remain an active and essential part of these communities by teaching youths valuable life skills they may not receive from anyone else.
Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis. Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation;; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis. -Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production -Focuses on the application of catalytic methods for the synthesis of known APIs -Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more -Includes recent patent literature for completeness Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.
Designed specifically for the needs, preferences, and styles distinct to long-term care this OSHA Compliance Management: A Guide for Long-Term Health Care Facilities serves as an excellent working reference. It focuses on priorities and provides you with the background and tools vital to achieving OSHA compliance and inspection preparedness. In this user-friendly, practical, hands-on manual you get: -Inspection preparedness briefing materials that provide you with last minute advice and activities -Real-life scenarios offering hands-on, practical advice and directions to minimize liability -Comprehensive policies with built in flexibility for designing mandatory practices to best fit your organization's needs -Summary discussions give you a quick, concise overview of all the issues covered including historical significance, current developments, and cautionary notes -Long-term care documentation, recordkeeping, and management tools for streamlining activities and maximizing necessary expended efforts -Step-by-step instructions for conducting and documenting specific types of assessments and information necessary for strategic decision and policy making -Flow charts, tables, and other materials containing long term care specific statistics and decision tree processes Streamline your organization's processes, save time and money, avoid liability, and improve safety management and performance. OSHA Compliance Management: A Guide for Long-Term Health Care Facilities gives you a headstart in achieving OSHA compliance and being prepared for OSHA inspections.
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