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The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. It is internationally recognised as the authoritative source of information on pharmaceutical excipients and a comprehensive guide to uses, properties and safety. Monographs benefit from a standardized, easy-to-use template and include: Pharmacopeial information from the UK, Europe, Japan and the United States where relevant Non-proprietary names and synonyms Chemical name, CAS Registry number, empirical formula, molecular weight Functional category, applications and incompatibilities Material description and typical properties Safety, stability, storage and handling information Method of manufacture Related substances Primary references Editorial comments Authors details and revision date Changes to this new edition: Contains revised and updated monographs 20 + new monographs including amino acids Arginine, Proline and Asparagine Includes newly added Raman spectra for many excipients New chapter content including information on excipients in oral solid dose formulations, and pediatric formulations
Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: Design considerations in biophysical-based lead screening Thermodynamic characterization of protein-compound interactions Characterizing targets and screening reagents with HDX-MS Microscale thermophoresis methods (MST) Screening with Weak Affinity Chromatography Methods to assess compound residence time 1D-NMR methods for hit identification Protein-based NMR methods for SAR development Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.
Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. This book and its accompanying CD-ROM comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management. Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries Includes a CD with downloadable training courses that can be adopted and directly customized to a particular organization Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the CD supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.
Taste is the number one driving force in the decision to purchase a food product and food consumption is the most critical function for living organisms to obtain the energy and resources essential to their vitality. Flavor and aroma are therefore universally important concepts: intrinsic to human well-being and pleasure, and of huge significance for the multi-trillion dollar global food business. How Flavor Works: the Science of Taste and Aroma offers a fascinating and accessible primer on the concepts of flavor science for all who have an interest in food and related topics. Professionals and students of food science and technology who do not already specialize in flavor science will find it a valuable reference on a topic crucial to how consumers perceive and enjoy food products. In this regard, it will also be of interest to product developers, marketers and food processors. Other readers with a professional (eg culinary and food service) or personal interest in food will also find the book interesting as it provides a user-friendly account of the mechanisms of flavor and aroma which will provide new insights into their craft.
Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.
A guide to membrane separation based on a variety of porous materials with promising separation applications Microporous Materials for Separation Membranes offers an in-depth guide that explores microporous materials? potential for membrane applications. The authors?two experts on the topic?examine a wide range of porous materials that have application potential including: microporous silica, porous carbons, zeolites, metal-organic frameworks (MOFs), and porous organic frameworks (POFs). Comprehensive in scope, the book covers a broad range of topics on membrane separations such as: hydrogen recovery, carbon dioxide capture, air purification, hydrocarbon separation, pervaporation, and water treatment. In addition, this up-to-date resource explores the most recent materials for preparing microporous membranes and explores the most promising applications for industrial use. This important book: -Examines the use of microporous materials as membranes to perform with different gases and liquids -Offers an overview of the basic knowledge of membrane separation and an intense examination of separations -Describes the state-of-the-art of membrane separation with porous materials -Highlights the most promising applications of industrial interest Written for scientists working in the fields of membranes, gas and liquid, Microporous Materials for Separation Membranes offers a valuable guide to the potential of microporous materials for membrane applications.
Alle Abbildungen zur 3. Auflage des CHMIEL (Hrsg.), Bioprozesstechnik. 3.A.
Die 3., berarbeitete und aktualisierte Auflage dieses Fachbuchs bietet eine Einf hrung in die Grundlagen der Bioprozesstechnik und erl utert die wichtigsten Parameter und deren Verhalten bei der Ma stabs bertragung. Damit liegt es voll "im Trend," denn es hilft Studenten der Biotechnologie und Ingenieurwissenschaften die an sie im Studium, in der Forschung und der industriellen Praxis gestellten Aufgaben zu erf llen
Das Werk beginnt mit einer Einf hrung in die Zellbiologie und Biochemie. Es folgen Beitr ge zur Kinetik von Enzymen und Mikroorganismen. Weitere Kapitel besch ftigen sich mit den Flie eigenschaften von Biosuspensionen und deren Einfluss auf Transportvorg nge im Bioreaktor. Die Funktionsweise von Bioreaktoren und das Problem der Sterilit t sowie die Mess- und Regeltechnik werden ausf hrlich behandelt. Mehr als die H lfte der Kosten eines Bioprodukts entfallen auf die Aufarbeitung; ihr wird deshalb besondere Beachtung geschenkt. Das Werk endet mit einem Kapitel zu den verfahrenstechnischen Besonderheiten von h heren Eukaryoten und Enzymen.
During the past decades, enormous progress and enhancement of pharmaceutical manufacturing equipment and its use have been made. And while there are support documents, books, articles, and online resources available on the principles of cleaning and associated processing techniques, none of them provides a single database with convenient, ready-to-use training tools. Until now. Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries elucidates how to train the man power involved in development, manufacturing, auditing, and validation of bio pharmaceuticals on a pilot scale, leading to scale-up production. With over 20 easy-to-use template protocols for cleaning validation of extensively used equipments, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors' more than two decades of experience in the pharmaceutical and biotech industries, the text offers hands-on training based on current approaches and techniques. The book does not merely provide guidelines or thought processes, rather it gives ready-to-use formulas to develop Master Plan, SOPs, and validation protocols. It includes cleaning procedures for the most commonly used equipment in various manufacturing areas and their sampling points, using a pharmaceutical manufacturing site with both sterile and non-sterile operations as the case facility. It also provides the training guidelines on a CD-ROM to enable users to amend or adopt them as necessary. Grounded in practicality, the book's applicability and accessibility set it apart. It can be used as a guide for implementing a cleaning validation program on site without the help of external consultants, making it a resource that will not be found collecting dust on a shelf, but rather, referred to again and again.
This handbook creates an understanding of food processing chemistry, engineering and technology, supported with select relevant case studies. An overview of food preservation and food preservatives is provided in great detail. The applied aspects of food preservation are dealt. Also, an advanced study of food additives, food irradiation and food storage is conducted. Focus lies on high pressure food preservation, curing, food dehydrator, fruit preserves, potted meat food product, jugging, drying, freeze drying, refrigeration and benefits of shaking well. Understanding food packaging and labelling in proper sense is the hallmark of this book. Study of code of hygienic practice for refrigerated packaged foods with extended shelf life in India is an additional input. The European and American guidelines with respect to food borne illness, food safety and standards are described in detail. Similarly, the regulations, claims and facts related to food labelling are covered extensively, supported with relevant case studies. An overview of global food industry, food marketing and food quality is discussed briefly. Select case studies related to food administration studies are done at global, regional and national levels. Necessary food information, food protection, food safety, food inspection and quality supervision are provided herein supported with select case studies from around the world. India's food processing industry and export worthy food sectors are also analysed. The scope of food processing industry in India, its present status and future prospects are also dealt.
Dieses kompakte EinfA1/4hrungslehrbuch vermittelt die wesentlichen Grundlagen der Technischen Chemie. Es richtet sich in erster Linie an Studierende der Chemie sowie des Chemie- und des Bioingenieurwesens und setzt lediglich solide Grundkenntnisse in organischer, anorganischer und physikalischer Chemie voraus. Das Werk ist in 19 etwa gleich lange Kapitel unterteilt, die jeweils ungefAhr dem Umfang einer doppelstA1/4ndigen Vorlesung mit Aoebung entsprechen. Die A1/4berschaubaren Einheiten erleichtern es auch, sich den Inhalt im Selbststudium anzueignen. Die vier KapitelblAcke a žGrundlagen," a žReaktions- und Trenntechnik," a žVerfahrensentwicklung" und a žChemische Prozesse" folgen im Wesentlichen dem a žLehrprofil Technische Chemie" des DECHEMA-Unterrichtsausschusses fA1/4r Technische Chemie.
Jedes Kapitel ist kompakt aufgebaut und mit Abbildungen, Gleichungen, FlieAschemata, Tabellen, Apparatezeichnungen und Fotos anschaulich gestaltet. Die Kapitel enden jeweils mit einer kurzen Zusammenfassung, den a žTake Home Messages." Diese rekapitulieren noch einmal alle wesentlichen Aussagen des Kapitels und ermAglichen eine zA1/4gige Wiederholung des Lernstoffes. ErgAnzt wird jedes Kapitel durch zehn kurze Testfragen, die sogenannten a žQuickies," die sich nach sorgfAltigem Durcharbeiten des Textes schnell lAsen lassen; die Antworten stehen zudem am Ende des Buches. Dort findet man ferner zu allen Kapiteln die Literaturangaben, die sich auf wesentliche Nachschlagewerke und LehrbA1/4cher konzentrieren.
This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.
Encompassing both biotechnology and chemical engineering, Microbial Functional Foods and Nutraceuticals brings together microbiology, bacteria and food processing/mechanization, which have applications for a variety of audiences: pharmaceuticals, diagnostics and medical device development all employ microbial food technology. The book will cover recent advances in microbial functional foods and associated applications, and will form an important reference work for graduates and researchers. The book will also provide up-to-date information on novel nutraceutical compounds and their mechanisms of action, catering to the needs of researchers and academics in food science and technology, microbiology, chemical engineering and other disciplines who are dealing with microbial functional foods and related areas.
This book introduces the theory and applications of nanometer photocatalysis, and it briefly presents the concept of photocatalysts, photocatalytic reaction mechanisms and kinetics, and photocatalytic reactor design. In addition, the use of photocatalysis in the control of flue-gas pollutants is discussed in detail. The book also describes how a photocatalytic reactor is designed and implemented to evaluate the photocatalytic oxidation capacity of different photocatalysts on elemental mercury in a simulated flue gas. After that, the effect of photocatalysts on the SO2, NOx and Hg removal in the flue gas is studied. Photocatalytic cleaning technology can be applied not only in gas pollutant cleaning at power plants, but also in wastewater purification. Readers gain a comprehensive understanding of possible mercury emission control methods and the industrial applications of these technologies.
Mayonnaise "takes" when a series of liquids form a semisolid consistency. Eggs, a liquid, become solid as they are heated, whereas, under the same conditions, solids melt. When meat is roasted, its surface browns and it acquires taste and texture. What accounts for these extraordinary transformations?
The answer: chemistry and physics. With trademark clarity and wit, Herve This launches a wry investigation into the chemical art of cooking. Unraveling the science behind common culinary technique and practice, Herv? This breaks food down to its molecular components and matches them to cooking's chemical reactions. He translates the complex processes of the oven into everyday knowledge for professional chefs and casual cooks; demystifies the meaning of taste and the making of flavor; describes the properties of liquids, salts, sugars, oils, and fats; and defines the principles of culinary practice, which endow food with sensual as well as nutritional value.
For fans of Herv? This's popular volumes and for newcomers to his celebrated approach, "The Science of the Oven" fuses the physiology of taste to the molecular structure of bodies and food, expertly expanding the possibilities of the kitchen.
This volume documents the proceedings of the "Second
International Symposium on Polyimides and Other High Temperature
Polymers: Synthesis, Characterization and Applications, held in
Newark, New Jersey, December 3-6, 2001.
Offering a unique perspective summarizing research on this timely important topic around the globe, this book provides comprehensive coverage of how molecular biomass can be transformed into sustainable polymers. It critically discusses and compares a few classes of biomass - oxygen-rich, hydrocarbon-rich, hydrocarbon and non-hydrocarbon (including carbon dioxide) as well as natural polymers - and equally includes products that are already commercialized. A must-have for both newcomers to the field as well as established researchers in both academia and industry.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors
'Cannabinoids' is a broad term covering a group of natural products from Cannabis sativa, one of which locks on to specific receptors - protein molecules on the surface of cells - known as cannabinoid receptors. Over the past decades scientists have found that cannabinoid receptors and their endogenous ligands, the endocannabinoids, are involved in a vast array of physiological functions, including helping to control brain activity, energy metabolism, heart function, the immune system and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic and molecular elements of cannabinoids, followed by chapters covering their role in health and disease. The final chapter outlines the need for a new nomenclature to reflect the complex and multi-disciplinary nature of this area.
A practical handbook rather than merely a chemistry reference, Szycher's Handbook of Polyurethanes, Second Edition offers an easy-to-follow compilation of crucial new information on polyurethane technology, which is irreplaceable in a wide range of applications. This new edition of a bestseller is an invaluable reference for technologists, marketers, suppliers, and academicians who require cutting-edge, commercially valuable data on the most advanced uses for polyurethane, one of the most important and complex specialty polymers. internationally recognized expert Dr. Michael Szycher updates his bestselling industry "bible" With seven entirely new chapters and five that are revised and updated, this book summarizes vital contents from U.S. patent literature-one of the most comprehensive sources of up-to-date technical information. These patents illustrate the most useful technology discovered by corporations, universities, and independent inventors. Because of the wealth of information they contain, this handbook features many full-text patents, which are carefully selected to best illustrate the complex principles involved in polyurethane chemistry and technology. Features of this landmark reference include: Hundreds of practical formulations Discussion of the polyurethane history, key terms, and commercial importance An in-depth survey of patent literature Useful stoichiometric calculations The latest "green" chemistry applications A complete assessment of medical-grade polyurethane technology Not biased toward any one supplier's expertise, this special reference uses a simplified language and layout and provides extensive study questions after each chapter. It presents rich technical and historical descriptions of all major polyurethanes and updated sections on medical and biological applications. These features help readers better understand developmental, chemical, application, and commercial aspects of the subject.
This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Practical reference on the latest sensory and consumer evaluation techniques available to professionals and academics working in food and consumer goods product development and marketing This unique manual describes how to implement specific sensory and consumer methods based on context and objective. Presented in a direct and straightforward language that will speak to the industry professionals and academics who are on the ground attempting to solve technical questions, it reviews, step by step, the various stages of a product evaluation. Included are practical examples from many industries that practitioners can relate to. The book also shows how to build a sustainable short-, medium-, and long-term product evaluation strategy, and guides readers on how to create customized methods, or even completely new approaches. Consumer and Sensory Evaluation Techniques speaks to management and decision-makers within organizations and addresses the main questions (eg: "How much will it cost?" and "How quickly can it be achieved?") that are faced when developing and testing new products before a launch. Chapters cover: the pillars of good consumer and sensory studies; sensory profile of a product: mapping internal sensory properties; the foundations of consumer evaluation; study plans and strategy--sustainable short, mid and long-term vision; real-life anticipation with market factors: concept, price, brand, market channel; and internal studies versus sub-contracting. Uses examples from multiple sectors to show how to build a sustainable product evaluation strategy Analyses the critical milestones to follow and the pitfalls to avoid Supports the decision-making process while developing fast yet robust test strategies that will increase the likelihood of a product's success Consumer and Sensory Evaluation Techniques is the perfect resource for students, faculty and professionals working in product development, including formulators and marketers.
This book summarizes the recent advances in the science and engineering of polymer-gel-based materials in different fields. It also discusses the extensive research developments for the next generation of smart materials. It takes an in-depth look at the current perspectives and market opportunities while pointing to new possibilities and applications. The book addresses important topics such as stimuli responsive polymeric nanoparticles for cancer therapy; polymer gel containing metallic materials; chemotherapeutic applications in oncology; conducting polymer-based gels and their applications in biological sensors; imprinted polymeric gels for pharmaceutical and biomedical purposes; applications of biopolymeric gels in the agricultural sector; application of polymer gels and their nanocomposites in electrochemistry; smart polyelectrolyte gels as a platform for biomedical applications; agro-based polymer gels and their application in purification of industrial water wastes; polymer gel composites for bio-applications. It will be of interest to researchers working in both industry and academia.
This volume is the second of the new two-volume Plant Biotechnology set. This volume covers many recent advances in the development of transgenic plants that have revolutionized our concepts of sustainable food production, cost-effective alternative energy strategies, microbial biofertilizers and biopesticides, and disease diagnostics through plant biotechnology. With the advancements in plant biotechnology, many of the customary approaches are out of date, and an understanding of new updated approaches is needed. This volume presents information related to recent methods of genetic transformation, gene silencing, development of transgenic crops, biosafety issues, microbial biotechnology, oxidative stress, and plant disease diagnostics and management. Key features: Provides an in-depth knowledge of various techniques of genetic transformation of plants, chloroplast, and fungus Describes advances in gene silencing in plants Discusses transgenic plants for various traits and their application in crop improvement Looks at genetically modified foods and biodiesel production Describes biotechnological approaches in horticultural and ornamental plants Explores the biosafety aspect associated with transgenic crops Considers the role of microbes in sustainable agriculture
Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides practical approaches to complex formulation problems encountered in the development of particulate delivery systems at the micro- and nano-size level. Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.
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