Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors' courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book's balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.

Phenomena associated with the adhesion interaction of surfaces have been a critical aspect of micro- and nanosystem development and performance since the first MicroElectroMechanicalSystems(MEMS) were fabricated. These phenomena are ubiquitous in nature and are present in all systems, however MEMS devices are particularly sensitive to their effects owing to their small size and limited actuation force that can be generated. Extension of MEMS technology concepts to the nanoscale and development of NanoElectroMechanicalSystems(NEMS) will result in systems even more strongly influenced by surface forces. The book is divided into five parts as follows: Part 1: Understanding Through Continuum Theory; Part 2: Computer Simulation of Interfaces; Part 3: Adhesion and Friction Measurements; Part 4: Adhesion in Practical Applications; and Part 5: Adhesion Mitigation Strategies. This compilation constitutes the first book on this extremely important topic in the burgeoning field of MEMS/NEMS. It is obvious from the topics covered in this book that bountiful information is contained here covering understanding of surface forces and adhesion as well as novel ways to mitigate adhesion in MEMS/NEMS. This book should be of great interest to anyone engaged in the wonderful and fascinating field of MEMS/NEMS, as it captures the current R&D activity.

Frying of Food is the first reference to examine frying of food from the point of view of changes occurring to biologically-active constituents and the effects of such changes on the stability, performance and nutritive value of frying oil. It focuses on the nature of the frying media and discusses changes to non-glyceride components, especially nutritive and non-utritive antioxidants. This important resource concentrates mainly on two factors that influence the deterioration of a fat at elevated temperatures: the nature of the heated fat and the presence of oxidation retardants, especially those naturally occurring in oils or obtained from natural sources. Discussions include important biologically active ingredients present in oils and fats (such as antioxidant vitamins and carotenoids) and minor constituents (such as phytosterols, phospholipids and hydrocarbons), which appear to affect the performance of a heated oil and/or may also be categorized as functional. Frying of Food also discusses olar phenolic compounds, which have an impact on the stability of oils at high temperatures. Food and lipid chemists, food technologists and product developers involved in the processing of foods by frying, and to those involved in fat and oil research, in quality assessment of heated fats, and in improving dietary fat intake profiles will find this book valuable.

Molecular structure is the most basic information about a substance, determining most of its properties. Determination of accurate structures is hampered in that every method applies its own definition of "structure" and thus results from different sources can yield significantly different results. Sophisticated protocols exist to account for these differences, but until now, no textbook has been written to discuss such topics in a widely accessible manner. Balancing quantum theory with practical experiments, Equilibrium Molecular Structures focuses on the theory involved in determining and converting measured and computed data sets into accurate and well-defined equilibrium structures. This textbook begins with a discussion of quantum chemistry and the concept of potential energy surfaces, quantum chemical computation of structures and anharmonic force fields. The reader is next introduced to the method of least squares and the problem of ill-conditioning, leverage points, perturbation theory, computational aspects of determining semi-experimental equilibrium structures, the determination of moments of inertia from spectra, and the treatment of resonances. The textbook also examines the determination of diatomic molecular potentials using semiclassical and quantum mechanical methods as well as position and distance averages. From basic elements to the latest advances and current best practices, Equilibrium Molecular Structures contains abundant references, examples, and exercises. Additional examples are also available as downloadable support material on the publishers website. These features make the book ideal for class instruction but also user-friendly for self-instruction. It is recommended for newcomers to the field and also for experienced spectroscopists who want to expand their area of knowledge.

Advances in Food Safety and Environmental Engineering is a compilation of selected papers from the 2022 4th International Conference on Food Safety and Environmental Engineering (FSEE 2022) and focuses on the research of food engineering and environmental engineering. The proceedings feature the most cutting-edge research directions and achievements related to health and environment. Subjects in these proceedings include: Food Safety and Health Food Nutrition Food Processing and Preservation Environmental Engineering and Technology Ecology and Ecosystem Management This collection of papers aims to promote food safety and environmental development, resource sharing, flexibility and high efficiency. An additional goal is to promote scientific information exchange globally between scientists from the best universities, research centers and high-tech companies.

When it comes to food selection, consumers are very reliant on their senses. No matter the date on a carton of milk or the seal on the package of meat, how that milk smells and the color of that meat are just as critical as any official factors. And when it comes to meal time, all the senses must conspire to agree that taste, smell, color, and texture are appealing. Fidel Toldra was named 2010 American Meat Science Association Distinguished Research Award recipient Compiled by two of the most esteemed researchers in the food science industry, Leo M.L. Nollet and Fidel Toldra, Sensory Analysis of Foods of Animal Origin identifies and quantifies the quality attributes to help those in the industry understand the importance of perceived sensory quality. This book is divided into four parts: meat; processed meats and poultry; fish and seafood products; and milk and dairy products. In all four parts, the authors - Describe the analysis of color and texture of the different foods of animal origin, as well as recent advances in texture measurement Discuss techniques for sampling and identifying volatile compounds Detail and quantify a number of sensory aspects including descriptors, perception, and aroma Include subjective quality index methods that have recently been developed Each chapter starts with a discussion of the parameter in question, and as necessary, sample preparation methods are reviewed in depth. This is followed by a discussion and assessment of the sensory qualities, or a detailed overview of different detection methods. Finally, a brief summary covers the presence of these parameters in different end products, regions, and countries. With all the chapters written by experts in their fields, only the most recent techniques and related literature is included.

The Encyclopedia of Biotechnology in Agriculture and Food provides users with unprecedented access to nearly 200 entries that cover the entire food system, describing the concepts and processes that are used in the production of raw agricultural materials and food product manufacturing. So that users can locate the information they need quickly without having to flip through pages and pages of content, the encyclopedia avoids unnecessary complication by presenting information in short, accessible overviews.

Addresses Environmental Issues & Sustainability in the Context of 21st Century Challenges

Edited by a respected team of biotechnology experts, this unrivaled resource includes descriptions and interpretations of molecular biology research, including topics on the science associated with the cloning of animals, the genetic modification of plants, and the enhanced quality of foods. It discusses current and future applications of molecular biology, with contributions on disease resistance in animals, drought-resistant plants, and improved health of consumers via nutritionally enhanced foods.

Uses Illustrations to Communicate Essential Concepts & Visually Enhance the Text

This one-of-a-kind periodical examines regulation associated with biotechnology applications?with specific attention to genetically modified organisms?regulation differences in various countries, and biotechnology's impact on the evolution of new applications. The encyclopedia also looks at how biotechnology is covered in the media, as well as the biotechnology/environment interface and consumer acceptance of the products of biotechnology. Rounding out its solid coverage, the encyclopedia discusses the benefits and concerns about biotechnology in the context of risk assessment, food security, and genetic diversity.

ALSO AVAILABLE ONLINE

This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for both researchers, students, and librarians, including:

• Citation tracking and alerts
• Active reference linking
• Saved searches and marked lists
• HTML and PDF format options

For more information, visit Taylor & Francis Online or contact us to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367 / (E-mail) [email protected] International: (Tel) +44 (0) 20 7017 6062 / (E-mail) [email protected] Dennis R. Heldman speaks about his work on the CRC Press YouTube Channel.

Authored by leading experts from around the world, the three-volume Handbook of Nanostructured Thin Films and Coatings gives scientific researchers and product engineers a resource as dynamic and flexible as the field itself. The first two volumes cover the latest research and application of the mechanical and functional properties of thin films and coatings, while the third volume explores the cutting-edge organic nanostructured devices used to produce clean energy.

This first volume, Nanostructured Thin Films and Coatings: Mechanical Properties, concentrates on essential properties such as hardness, toughness, and adhesion. It looks at process and performance and offers a detailed analysis of theories and size effect. It also covers:

• Fundamentals of hard and superhard nanocomposites and heterostructures
• Determination of hardness and modulus of thin films
• Fracture toughness and interfacial adhesion strength of thin films: Indentation and scratch experiments and analysis
• Toughness and toughening of hard nanocomposite coatings
• Processing and mechanical properties of hybrid sol-gel-derived nanocomposite coatings
• Use of nanomechanics to optimize coatings for cutting tools
• Electrolytic deposition of nanocomposite coatings: Processing, properties, and applications

This book presents an industrial perspective on diamond and metal-containing amorphous carbon nanostructured coatings and transition metal nitride-based nanolayered and nanocomposite coatings. It also covers polymer films, from nanoscale synthesis to macroscale functionality.

A complete resource, this handbook provides the detailed explanations that newcomers need, as well as the latest cutting-edge research and data for experts. Covering a wide range of mechanical and functional technologies, including those used in clean energy, these books also feature figures, tables, and images that will aid research and help professionals acquire and maintain a solid grasp of this burgeoning field.

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The Handbook of Nanostructured Thin Films and Coatings is composed of this volume and two others:

Nanostructured Thin Films and Coatings: Functional Properties

Organic Nanostructured Thin Film Devices and Coatings for Clean Energy

Biologically active natural products and their substructures have long been valuable starting points for medicinal chemistry and drug discovery. This new volume explores biologically active natural products and their use in microbial technologies and as phyto-pharmaceuticals in drug development. It presents detailed scientific principles and recent research on applications of nanotechnology in diagnostics and drug delivery. Topics include pharmacotherapeutically active proteins and peptides; the biotechnological potential of hydrogen-oxidizing bacteria; synthesis and production; synthetic colorants, pigments, dyes, and lakes; and more. The use of various plants is discussed in several chapters, including Artemisia, Asteraceae, Abutilon indicum, Prosopis juliflora, Acacia arabica, Aloe barbadensis, Tabermontana divaricate Linn., among others. With the information presented in Biologically Active Natural Products: Microbial Technologies and Phyto-Pharmaceuticals in Drug Development, scientists, faculty, and graduate students will gain a unique insight into nanotechnology and natural pharmaceuticals today with practical implementation in various industrial sectors.

Modern food biotechnology is now a billion-dollar industry, producing functional foods and nutraceuticals that offer a whole host of increased health benefits, including prevention against illness, and chronic and degenerative conditions. Written by a team of top-tier researchers and scientists from around the world, Biotechnology in Functional Foods and Nutraceuticals brings you up to speed on the cutting-edge research advances taking place in the field.

The book begins with an overview of recent advances in biotechnology and their contributions to food science. It then examines the impact of genetic modification on functional foods and explores various aspects of food manufacturing technology. This one-of-a-kind resource also gives insight into quality assurance and food safety and an assessment of where the field currently stands on legal, social, and regulatory aspects of food biotechnology. The book rounds out its solid coverage with a look at future directions in the applications of biotechnology to functional foods and nutraceuticals.

Biotechnology in Functional Foods and Nutraceuticals is the first book of its kind to position functional foods and nutraceuticals in the broader context of emerging technologies, making it a one-stop reference for food and nutrition scientists as well as researchers in the functional foods and nutraceuticals industries, nutritionists, dieticians, and supplement manufacturers.

An examination of systematic techniques for the design of sustainable processes and products, this book covers reducing energy consumption, preventing pollution, developing new pathways for biofuels, and producing environmentally friendly and high-quality products. It discusses innovative design approaches and technological pathways that impact energy and environmental issues of new and existing processes. Highlights include design for sustainability and energy efficiency, emerging technologies and processes for energy and the environment, design of biofuels, biological processes and biorefineries, energy systems design and alternative energy sources, multi-scale systems uncertain and complex systems, and product design.

Here is an informative overview of the latest trends of nanotechnology-based packaging in the food industry, a rapidly advancing area with potential for the development of polymer nanocomposites for stronger, lighter, cheaper, more functional, and safer food packaging materials. The volume discusses the advances, functions, and applications of nanotechnology in food packaging as well as the important properties of polymer nanocomposites as packaging materials. Chapters address the major preparative methods and the varied quantitative and qualitative analytical techniques used. Other topics include nanofillers used for the design of active antimicrobial and antioxidant packaging systems, smart/intelligent nanocomposite packaging (including sensors, indicators, bar codes, and radiofrequency indicators), various natural and synthetic biopolymers available and their suitability to fabricate bionanocomposite food packaging, the role of nanotechnology in preserving and maintaining the odor and flavor of packed food, and nanotechnology-based edible packaging in the form of coatings and thin films. Importantly, the book also assesses the possible health and safety issues associated with the involvement of nanotechnology in food applications.

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive database of solubility for pharmaceuticals in mono solvents and binary solvents. Aqueous solubility data can be found in the Handbook of Aqueous Solubility Data by Samuel Yalkowsky and Yan He. Visit www.crcpress.com for more information.

In addition to the experimental efforts to measure the solubility of drugs in mono and mixed solvents, this book discusses the advantages and limitations of a number of mathematical models used to predict the solubility in mono or mixed solvent systems. It covers the pharmaceutical cosolvents and other organic solvents that are used in syntheses, separations, and other pharmaceutical processes. The solutes featured include the available data for official drugs, drug candidates, precursors of drugs, metabolites, and degradation products of pharmaceuticals. The author also presents the solubilities of amino acids since they play an important role in peptide drug properties.

Collecting drug solubilities in various cosolvents, this time-saving handbook includes the mixtures and model constants needed to predict undetermined solubilities. It describes mathematical models that enable data to be derived and provides estimates on how drugs are likely to behave in a given cosolvent. A software program and associated user manual are available on the author s website.

Discusses the chemistry of ingredients and techniques in Thai cuisine with possibilities of application and innovation Presents scientific research combined with arts and history of Thai food Provides scientific evidence linking Thai food with the sensory perception and the joy of eating Contains vibrant color photographs of Thai cuisine

Discusses the chemistry of ingredients and techniques in Thai cuisine with possibilities of application and innovation Presents scientific research combined with arts and history of Thai food Provides scientific evidence linking Thai food with the sensory perception and the joy of eating Contains vibrant color photographs of Thai cuisine

Examines harmonization of the US Federal Food, Drug, and Cosmetic Act with international regulations as they apply to human drug and device development, research, manufacturing, and marketing. The Second Edition focuses on the new drug approval process, cGMPs, GCPs, quality system compliance, and corresponding documentation requirements. Written in a jargon-free style, it draws information from a wide range of resources. It demystifies the inner workings of the FDA and facilitates an understanding of how it operates with respect to compliance and product approval. FDA Regulatory Affairs: provides a blueprint to the FDA and drug, biologic, and medical device development offers current, real-time information in a simple and concise format contains a chapter highlighting the new drug application (NDA) process discusses FDA inspection processes and enforcement options includes contributions from experts at companies such as Millennium and Genzyme, leading CRO's such as PAREXEL and the Biologics Consulting Group, and the FDA Three all-new chapters cover: clinical trial exemptions advisory committees provisions for fast track

Includes extensive information on the use of innovative or emerging technologies aiming to promote circular exploitation systems. Promotes the full use of the cereal and non-cereal sourdough metabolites. Covers the functionality of sourdough microorganisms and functional compounds and future exploitation of some of them in the field of nutraceuticals or functional foods

Named #1 of 15 Best New Biotechnology Books to Read in 2021 by BookAuthority. This volume explores and explains the vast uses and benefits of algae as food, feed, and fuel. It covers the most advanced applications of algae in the food and feed industries and for environmental sustainability. With chapters written by experts and which were extensively reviewed by many well-known subject experts and professionals, Phycobiotechnology: Biodiversity and Biotechnology of Algae and Algal Products for Food, Feed, and Fuel provides an abundance of valuable information. Algae are a genetically diverse group of organisms with a wide range of physiological and biochemical characteristics that have unique capabilities in the fields of agriculture, pharmaceuticals, industry, and environment. Algae hold the potential to become the planet's next major source of energy and a vital part of the solution for climate change and dependence on fossil fuels. Many varieties of algae are also known to be an abundant source of vitamins, minerals, and other nutrients that can boost the human immune system.

Presents potential biotechnological topics and strategies for the valuation of agricultural waste materials Provides technical concepts on the production of various commercially significant bio-products Introduces various microbial bioprocesses to sustainably valorise various potential wastes as renewable feedstocks for production of biofuels and biochemicals Explores the relevant scale-up opportunities, commercialization aspects and critical technological advances Explains concepts and recent trends in life cycle analyses in waste valorization

Derived from the fourth edition of the well-known "Plastics Technology Handbook," Industrial Polymers, Specialty Polymers, and Their Applications covers a wide range of general and special types of polymers, along with a wealth of information about their applications.

The book first focuses on commonly used industrial polymers, including polypropylenes, low- and high-density polyethylenes, and poly(vinyl chloride), as well as less widely used polymer types, such as acrylics, ether polymers, cellulosics, sulfide polymers, silicones, polysulfones, polyether ether ketones, and polybenzimidazoles. It then explores polymer derivatives and polymeric combinations that play special and often critical roles in diverse fields of human activities. The polymers covered include liquid crystal, electroactive, ionic, and shape memory polymers; hydrogels; and nanocomposites. The volume concludes with a comprehensive overview of new developments in the use of polymers in a variety of areas.

This book focuses on novel electrochemical materials particularly designed for specific energy applications. It presents the relationship between materials properties, state-of-the-art processing, and device performance and sheds light on the research, development, and deployment (RD&D) trend of emerging materials and technologies in this field. Features: Emphasizes electrochemical materials applied in PEM fuel cells and water splitting Summarizes anode, cathode, electrolyte, and additive materials developed for lithium-ion batteries and reviews other batteries, including lithium-air, lithium-sulfur, sodium- and potassium-ion batteries, and multivalent-ion batteries Discusses advanced carbon materials for supercapacitors Highlights catalyst design and development for CO2RR and fundamentals of proton facilitated reduction reactions With a cross-disciplinary approach, this work will be of interest to scientists and engineers across chemical engineering, mechanical engineering, materials science, chemistry, physics, and other disciplines working to advance electrochemical energy conversion and storage capabilities and applications.

An Examination of Detergent Applications

The fifth volume in a six volume project penned by detergent industry experts, this segment deals with the various applications of detergent formulations - surfactants, builders, sequestering/chelating agents - as well as other components. These applications are discussed with respect to the scope of their domestic, institutional, or industrial usages. Special focus is given to technological advancement, health and environmental concerns, and the rapid changes occurring in the field within the past several years. With each chapter providing the special access of a pioneering researcher, this text offers an insider's look at the most current advances.

Most adults take at least one prescription medication for example, for high blood pressure, high cholesterol levels, depression, asthma, diabetes, COPD, or a variety of other reasons, but most people (and many healthcare providers) are totally unaware that medications can have direct negative effects on sexual functioning and performance. This informative and timely book written by three well-known medications experts explores the chemistry behind sexual arousal in men and women and clearly and authoritatively explains how the common categories of prescription and over-the-counter medications and abused substances might be the reason for their declining sexual performance or even interest.

Fresh? Juice? Paste? Canned? Stewed? Diced? Pureed? Sun Dried? Salsa? Sauce? Ketchup? Rare is the cuisine that does not make use of the tomato in some way, shape, or form, and the resulting culinary popularity of the tomato has led to its proliferation in fields and farms around the world. While some may still argue whether the tomato is a fruit or a vegetable, few would argue that tomato crops are highly lucrative, attractive to farmers in both developing and developed countries and on large and small farms alike. In fact, for those crops with significant global volume and market share, tomatoes are the highest valued among those crops that lack an affiliation to mind-altering drugs. But, the tomato can be a persnickety critter. The tomato doesn't like it too hot, too chilly, too wet, too dry, or too fertile. Many don't ripen at the same time. Most are easily bruised. And, the selective breeding that has yielded a larger, more attractive, and deep red tomato has also mercilessly drained much of the taste and flavor from a once sweet and delectable fruit. Enter the world of sensors and modern sensing technology. The Internet of Things (IOT), when using well chosen, well networked, and well aggregated sensors, has shown tremendous potential to support precision agriculture, providing a more detailed picture of crops than was previously possible using conventional crop monitoring techniques. But, the stringent resources and tight profit margins that are a fact of life among many tomato growing operations, large and small, mean that sensor technologies must be chosen and used carefully. There is no doubt that each sensor must earn its keep in producing the perfect tomato. With that in mind, this book explores key opportunities to marry the potential of sensors that are networked within the IOT to the needs of tomato production in ways that are economically fruitful, technologically robust, and sustainable overall.

Lycopene is a potent antioxidant carotenoid found in fruits and vegetables; particularly high amounts exist in red tomatoes. It is not an essential nutrient for humans, but can be a potential therapeutic agent for preventing several human diseases. Since the publication of the previous book on lycopene, extensive advances have been made with respect to the role of lycopene and tomatoes in human health. Whereas the initial focus of research was on cancer, Lycopene and Tomatoes in Human Nutrition and Health represents the next major step in documenting advances in understanding the chemistry, bioavailability, metabolism; mechanisms of action of lycopene; and its role in preventing human diseases other than cancer as discussed in the various chapters of the book. The book includes chapters that discuss genetic polymorphisms; and lycopene's relationship to cardiovascular diseases, cardiometabolic diseases, bone health, and other health disorders including male infertility, skin diseases, respiratory disorders and neurodegenerative diseases. The book includes information addressing regulatory aspects of natural health products and, in particular lycopene, presenting industrial insights. The contents of the book are selected carefully to provide the readers with the most current information available on lycopene and tomato bioactives.