This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.
Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions.
Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.

The manufacturing industries remain the foundation of local, regional, and global economies. Manufacturing plants operate in dynamic markets that demand upgrading with transformational technologies for maintaining profitability, competitiveness, and business sustainability. Yet most manufacturing plants currently use technologies that are no longer competitive and industry leaders face an overwhelming array of operational challenges that require agile and enhanced transformational solutions. This book offers manufacturers effective strategies and tools for the adoption and implementation of advanced operational technologies to ensure long-term innovation, efficiency, and profitability. The book covers advanced automation integration in manufacturing, including digitization, AI, machine learning, IIoT, and cybersecurity. It describes innovation, development, and integration of control technologies for sustainable manufacturing. It explains how to upgrade existing manufacturing plants for the global market. It shows how to apply emerging technologies including asset optimization and process integration for product lifecycle improvements, plant operation and maintenance enhancement, and supply chain integration. This book serves as a strategic guide to applying advanced operational technologies for engineers, industry professionals, and management in the manufacturing sector.

Explores Cost Impact of Process Intensification, and their relative magnitudes, as a universal metric. Covers a range of industrial applications, including heat and mass transfer, atomization and comminution, and nano-composite synthesis. Discusses the application of Process Intensification for clean technology and environmental remediation. Includes end-of-chapter problems, examples, and case studies.

An outstanding resource which enables readers to better understand the conditions that led to these Nobel Prize amazing discoveries To an extent the roots of organic chemistry have been forgotten or lost and this set of volumes bridges the gap Unique set of volumes, no other book publication in the field competes and only press releases announcing the prizes from recent years exist "More than any other branch of chemistry, organic chemists look to history, so the readers will certainly enjoy this compilation " Appeals to a diverse audience including upcoming as well as modern practicing chemists, and provides the historical context of these discoveries

This compilation on the degradation of 1,100 commercially important chemical products is the first publication to make this knowledge publicly accessible in one book. The data and annotations have been painstakingly assembled over a 10-year period in a collaboration between academia and regulatory authorities. The work explains in detail the methods, including computational ones, for the environmental assessment of volatile and semi-volatile substances, and is rounded off with data tables of degradation rates.
A key resource for manufacturers and regulators of such substances.

This volume takes an in-depth look at various biological and chemical hazards in food and food products that pose health threats. It also outlines methods and practices for the diagnosis, prevention, and management of these hazards in food production processes. The new scientific research and case studies presented in the volume cover mycotoxins, foodborne pathogens, antibiotic residues from dairy animals, pesticide residues, the presence of heavy metals in food, and more. Chapters also address food allergy management and offer lessons and practices in food recall situations. The authors discuss the various food toxins, their sources, as well as management, mitigation, and prevention strategies. Also addressed are the specific adverse effects on people with health problems such as diabetes, hypertension, cancer, neurodegenerative diseases, and more. This book is organized in such a way that each chapter treats one major food safety hazard and offers novel control methods for health, food safety, and quality enhancement through various means. Biological and Chemical Hazards in Food and Food Products: Prevention, Practices, and Management will aid researchers and policymakers as it illustrates the various aspects of food safety hazards and how to analyze and control these potential health threats.

Authenticity Food Traceability Applied Techniques and Methods Foods of Plant Origin

In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Producing and Consuming the Craft Beer Movement is an ethnographic analysis of the craft beer movement and its rapid development as an industry that articulated a different set of values: celebrating, quality, community, and good taste. This book will provide an excellent foundation for considering craft beer and an entrepreneurial practice that produces other forms of value beyond monetary value. The craft beer movement has been an important movement for thinking about contemporary consumer culture, and how that consumer culture might develop a very different set of values and priorities from those of the dominant consumer culture that is created by large-scale industries focused on the instrumental values of profit and efficiency. Located in one site, the ethnography is situated within the larger context of the rise of digital media, the evolution of cities, and the latest stage of the capitalist marketplace. The book is distinctive as it is ethnographic in its methodology. It is focused on one locale, the metropolitan area around Philadelphia. Philadelphia, along with Boston, Denver, San Diego, and a few other cities, was a central location for the early development of the craft beer industry. With its interdisciplinary approach, individuals with interests in digital and social media, consumer culture, political economy, ethnography, and contemporary cultural theory will find this an interesting case study of an important industry that developed from the homebrewing movement to become an important craft industry that is now a global phenomenon. This book is directed to a broad range of readers interested in new media, consumer culture, craft, and contemporary capitalist culture. The book embeds the local in the larger historical and political economic context. Readers would include faculty members in communication, media studies, cultural studies, sociology, and anthropology. Students at a graduate and upper level undergraduate level would be interested as well.

Handbook of Thermoset Plastics, Fourth Edition provides complete coverage of the chemical processes, manufacturing techniques and design properties of each polymer, along with its applications. This new edition has been expanded to include the latest developments in the field, with new chapters on radiation curing, biological adhesives, vitrimers, and 3D printing. This detailed handbook considers the practical implications of using thermoset plastics and the relationships between processing, properties and applications, as well as analyzing the strengths and weakness of different methods and applications. The aim of the book is to help the reader to make the right decision and take the correct action on the basis of informed analysis - avoiding the pitfalls the authors' experience has uncovered. In industry, the book supports engineers, scientists, manufacturers and R&D professionals working with plastics. The information included will also be of interest to researchers and advanced students in plastics engineering, polymer chemistry, adhesives and coatings.

The replacement of fossil-derived compounds by bio-based fuels and chemicals is crucial for the implementation of a sustainable bioeconomy. In this context, microorganisms are key players for biofuels' production from renewable sources. Biotechnological biofuel production processes require conversion microorganisms capable of both efficiently assimilating renewable low-cost carbon sources and diverting their metabolisms towards the specific biofuel. Exploring the wide diversity of microorganisms available on Earth will surely aid to make the production of green fuels a reality. This book gives a wide overview of different microbial-based processes for green fuels production. The book also includes techno-economic analysis and highlights strategic, commercial and environmental interests in promoting green fuels. All these facts make this book very valuable not only for the scientific community but also for biofuel companies and policy makers.

The Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications, Second Edition provides detailed information on membrane separation technologies from an international team of experts. The handbook fills an important gap in the current literature by providing a comprehensive discussion of membrane applications in the chemical, food, pharmaceutical, and biotechnology industries as well as in the treatment of toxic industrial effluents. This revised second edition has been updated and expanded with discussions of new membrane products and processes and novel applications in engineering, life sciences, and energy conversion. It also includes new chapters in the field of membrane science and technology covering recent advances in RO and UF, ionic liquids, nanotechnology, roles of membrane in power generation, updates on fuel cells, new membrane extraction configuration, and other important topics. The handbook is equally suited for the newcomer to the field as it is for process engineers and research scientists (membranologists/membrane experts) who are interested in obtaining more advanced information about specific applications. It provides readers with a comprehensive and well-balanced overview of the present state of membrane science and technology.

This handbook provides an in-depth review of information across the developmental spectrum of gene and cell therapy products. From introductory information to state-of-the-art technologies and concepts, the book provides insights into upstream processes such as vector design and construction, purification, formulation and fill/finish as well as delivery options. Planning steps for compliance with current good manufacturing practice (CGMP) to readiness for chemistry, manufacturing, and controls (CMC) are also discussed.This book wraps up with examples of successes and pitfalls addressed by experts who have navigated the multiple challenges that are part of any innovative endeavor. Features Intended as a one-stop resource for availability of state-of-the-art information related to cell and gene therapy products for researchers, scientists, management and other academic and research institutions. Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing. Discusses siRNA, mRNA, and plasmid manufacturing. Describes the importance of supplier-sponsor synergies on the path to commercialization. Diverse audience with a large number of individuals in the core technologies and supportive practices.

As the broad challenges around energy and the environment have become the focus of much research, scientists and experts have dedicated their efforts to developing more active and selective catalytic systems for key chemical transformations. For many decades environmentally viable protocols for the synthesis of fine chemicals have been the crux of academic and industrial research. Heterogeneous Catalysis in Organic Transformations serves as an overview of this work, providing a complete description of role of heterogeneous catalysis in organic transformations and offering a review of the current and near future technologies and applications. Discusses the fundamentals of catalysis and compares the advantages and disadvantages of different types of catalyst systems Examines oxide nanoparticles and noble metal nanoparticles Consider organometallic compounds, solid-supported catalysts, and mesoporous materials Describes recent advances in metal-based heterogeneous catalysts and new reactions with possible mechanistic pathways Providing a comprehensive review of heterogeneous catalysis from the basics through recent advances, this book will be of keen interest to undergraduates, graduates, and researchers in chemistry, chemical engineering, and associated fields.

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare-i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

This new book, Advances in Energy Materials and Environment Engineering, covers the timely issue of green applications of materials. It covers the diverse usages of carbon nanotubes for energy, for power, for the protection of the environment, and for new energy applications. The diverse topics in the volume include energy saving technologies, renewable energy, clean energy development, nuclear engineering and hydrogen energy, advanced power semiconductors, power systems and energy and much more. This timely book addresses the need of the hour and will prove to be valuable for environmentally conscious industry professionals, faculty and students, and researchers in materials science, engineering, and environment with interest in energy materials.

First volume selling primarily in the United States, push for more global promotion. "non-invasivel" related healing modalities and environmental medicine are both very hot topics. There are not any existing books with this dual focus that have an accompanying successful volume on nutrition and integrative medicine.

Comprehensive Foodomics, Three Volume Set offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josic, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljevic Pavelic, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics - Daniel Cozzolino, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Australia Food Bioactivity, Health and Foodomics - Miguel Herrero, Department of Bioactivity and Food Analysis, Foodomics Lab, CIAL, CSIC, Madrid, Spain

Despite 40 years of aggressive pharmaceutical and surgical interventions, coronary artery disease remains the number one killer of women and men in Western civilization. Cardiovascular disease, more than ever, demonstrates the landscape has changed so significantly, that new information must be given to the young and old health professionals seeing patients on a day to day basis. Dr. Sinatra has 40 plus years of experience in cardiovascular disease and is board-certified in internal medicine and cardiology. Dr. Mark Houston practices integrative nutritional preventive cardiology and has superb expertise in hypertension, and dyslipidemia which are major factors in the genesis of cardiovascular disease. The information in this book will give doctors-to-be, and even doctors-that-are the overlooked information they need for a balanced approach to cardiovascular treatment that includes a healing/healthy diet, nutritional supplementation, exercise and weight management. Those are crucial and powerful additions to the toolbox with which to maintain health and fix problems. That's the integrative approach that Dr. Sinatra, Dr Houston and his fellow authors, have been using with great success for decades. The Table of Contents shows a true revision - all new material - this is more of a companion volume to the original edition.

"Algae are mysterious and fascinating organisms that hold great potential for discovery and biotechnology." -Dr. Thierry Tonon, Department of Biology, University of York "Science is a beautiful gift to humanity; we should not distort it." -A.P.J. Abdul Kalam In this book, we emphasize the importance of algal biotechnology as a sustainable platform to replace the conventional fossil-based economy. With this focus, Volume 2 summarizes the up-to-date literature and knowledge and discusses the advances in algal cultivation, genetic improvement, wastewater treatment, resource recovery, commercial operation, and technoeconomic analysis of algal biotechnology. FEATURES Discusses in detail recent developments in algae cultivation and biomass harvesting Provides an overview of genetic engineering and algal-bacteria consortia to improve productivity Presents applications of algae in the area of wastewater treatment and resource recovery Provides case studies and technoeconomic analysis to understand the algal biorefinery Shashi Kant Bhatia, PhD, is an Associate Professor in the Department of Biological Engineering, Konkuk University, Seoul, South Korea. Sanjeet Mehariya, PhD, is a Postdoctoral Researcher at the Department of Chemistry, Umea University, Umea, Sweden. Obulisamy Parthiba Karthikeyan, PhD, is a Research Scientist and Lecturer (Adjunct) in the Department of Civil and Environmental Engineering, South Dakota School of Mines and Technology, Rapid City, South Dakota, USA.

In this book we present recent studies that have been carried out on some widely used medicinal plants. The need for new and alternative treatments stem from the lack of efficiency of existing remedies for certain illnesses. We have compiled information that may be useful to researchers in their quest to develop new drugs.

For many centuries, fenugreek has been one of the most popular spices and vegetables serving as an integral part of culinary practices across many cultures. Fenugreek contains exceptional nutritional and medicinal properties, but scientific evidence for its potential health benefits has been considerably understudied and is beginning to grow. This book is a comprehensive compilation and documentation on the scientific profile of fenugreek and its phytoconstituents, including their most known applications and health benefits. It features a wide range of chapters written by highly experienced academics and industrial professionals. Topics cover applications of fenugreek including information on nutrition, fitness supplements, functional food, and excipients of novel drug delivery systems. In addition, it features topics on related products in the areas of nutraceuticals, functional food preparations, and complementary medicines. Features: * Comprehensive review of traditional wisdom and modern scientific evidence on fenugreek * Presents scientific evidence of fenugreek as an ingredient for product development formulation * Contains information on extraction methods, risk assessment, claim validations, and the regulatory status of fenugreek-based products * Covers broad physiological benefits of fenugreek in management of diabetes mellitus, primary hyperlipidemia, inflammation and pain, neuropathy and neuroinflammation, neurological and psychological disorders, kidney and lung disorders, as well as immunological, infectious, and malignant disorders * Enhances awareness of existing scientific knowledge surrounding fenugreek, whilst encouraging future scientific research towards better and safer nutritional and medicinal applications This book is a valuable resource of information on fenugreek for researchers, students, nutritionists, sport medicine practitioners, fitness enthusiasts and trainers, naturopaths, traditional practitioners, and toxicologists. This book helps industries in the fields of nutraceuticals, fitness and sports medicine products to develop their future products. However, this book is not a substitute for medical advice or recommendations.

The 31st European Symposium on Computer Aided Process Engineering: ESCAPE-31, Volume 50 contains the papers presented at the 31st European Symposium of Computer Aided Process Engineering (ESCAPE) event held in Istanbul, Turkey. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students and consultants in the chemical industries.

Emerging microbial and viral infections are a serious challenge to health, safety, and economics around the world. Antimicrobial and antiviral technologies are needed to disrupt the progression and replication of bacteria and viruses and to counter their rapidly evolving resistance. This book discusses recent developments in materials science and engineering in combating infectious diseases and explores advances in antimicrobial and antiviral materials, including polymers, metals, and ceramics and their applications in the fight against pathogens. Features * Covers progress in biomimetic antimicrobial and antiviral materials and antimicrobial/antiviral bulk materials and coatings * Describes modern methods for disinfection of biomedical materials against microbial and viral infection resistance, especially for depressing novel coronavirus (COVID-19) * Details methods to improve material properties to have a longer service life in combating infection * Emphasizes chemical, physical, mechanical, tribological, and antimicrobial/antiviral properties * Offers current and future applications of emerging antimicrobial/antiviral technologies This book will be of interest to materials researchers and industry professionals focusing on antimicrobial and antiviral applications.